Doctor insights on:
Anti Sm Antibody Test
Marker for SLE: Systemic lupus erythematosus can exist without a positive test result but a positive result =SLE. This is not a happy Dx, but some people are well managed by good treatment and compliance w/ recommendations for how to live. A specialist Health Psychologist is often a great asset in learning how to deal w/ the condition and symptoms that can include and/or cause emotional problems. Best! ...Read more
What is considered a positive result for the SM antibody for SLE? My Ana 1:320 but DNA was negative. So many blood tests for SLE diagnosis!!
The only pos blood test I have is ANA of 1:320. Neg RF CCP DNA and SM antibody was low of 10. Extreme joint pain 6 mnth. RA, lupus, or neither?!
+ ANA: There are other spondyloarthropathy that can cause a lot of pain and will require treatment. Did they do an HBLA27 test? Make sure you f/u with your rheumatologist. If you have RA you can get these results. You may need to start a biologic medication. Good luck and feel better soon) ...Read more
Depends on whose sm: Different labs have different ranges for their positive test. They usually set the range for detection at a certain level. Below that level they have many people without lupus that would have a + test. Above that level is what they call a + test. But not all labs are created equal - so each has there own level determined by their scientific investigations. ...Read more
Positive ANA....Positive SM Antibody of 39 units....Positive RNP of 32 units. What would these numbers mean in comparison to tiers or to Lupus?n
See below: SM antibodies are specific for systemic lupus and are often associated with anti-RNP antibodies. They are commoner in Blacks and Asians. It is not an indicator of severity or predictor of organ involvement, which requires careful history, physical and other tests, preferably in the hands of a certified rheumatologist. ...Read more
Probably nothing: That low titer is not impressive, usually the RNP. Ask the doctor who ordered it. Why was the test ordered in the first place? ...Read more
Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?
Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read moreSee 1 more doctor answer
Depends why elevated: This depends on why you have an elevated ANA. It can be there for lots of reasons. Classically we use this to diagnose systemic lupus erythematosus but most people with a positive ANA do not have systemic lupus erythematosus. As a rheumatologist we are asked to see a lot of people with a positive ANA Most of the time we find some other cause. Yours is high but it may not be high for any bad reason ...Read more