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Doctor insights on: Anti Scleroderma 70 Antibody

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I have lupus- diagnosed w/labs and symptoms. But had no antibodies positive- all were 0 except my ssa was 8 (0-40 is neg) & scl-70 was 3 (0-40 neg) should I be concerned about scleroderma? Very scared!

I have lupus- diagnosed w/labs and symptoms. But had no antibodies positive- all were 0 except my ssa was 8 (0-40 is neg) & scl-70 was 3 (0-40 neg) should I be concerned about scleroderma? Very scared!

Rheumatologist.. ..: You need to see a rheumatologist to sort out the lupus question. Lots of symptoms but zero lab evidence may not necessarily be lupus. Make sure diagnosis is right! ...Read more

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Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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Possibility of having scleroderma w/ negative scl-70 & negative anti-centromere antibodies? No raynauds, but bad GERD w/ PPI's not workin, I have lupus

Possibility of having scleroderma w/ negative scl-70 & negative anti-centromere antibodies? No raynauds, but bad GERD w/ PPI's not workin, I have lupus

History / physical: Scleroderma is diagnosed on history and physical exam. Without Raynaud's, it's unlikely. The labs aren't altogether sensitive. I'd address the GERD as a separate issue, and continue as you're probably already doing keeping a close eye on your lupus as a proactive patient. Best wishes. ...Read more

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Lily is testing for scleroderma. Her antibodies came back negative, she had 100 mg of protein in her one-time urine sample. Is that very high? Sheis15

Lily is testing for scleroderma. Her antibodies came back negative, she had 100 mg of protein in her one-time urine sample. Is that very high? Sheis15

Doubt scleroderma: We'd rather that a 24 hour urine sample contain 150 mg or less of protein; you haven't given us the sample type. Several percent of people have protein in their urine just from standing up, and this needs to be ruled out before anybody gets all worried about her kidneys. Unlike lupus, scleroderma isn't a famous cause of proteinuria, but rather of renovascular hypertension. Stay proactive. ...Read more

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I have had scl70 antibodies for scleroderma sine scleroderma. Now I have severe shortness of breath, tightness in my chest, body aches and dizziness.?

Would also be: I would be concerned about interstitial lung disease secondary to scleroderma as well pulmonary hypertension as the blood clots mentioned by colleague. You need to see your rheumatologist to have a workup performed in order to confrim or rule out what you may have. ...Read more

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My test results show possitive for scleroderma scl 70 result 1.1. I'm scare is it bad? Please help...

No: By itself, the test means nothing. If you have the signs of scleroderma as diagnosed by an expert such as a rheumatologist or a dermatologist, then the scl-70 test can confirm the diagnosis of scleroderma. The value does not indicate the severity. Again, the test alone does not give the diagnosis. ...Read more

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Tested positive for 2nd time ANA 1:160 centromere on 3/4 n 4/5. Tested neg 4 sl-70. What additional test can be done to rule out crest/scleroderma?

Tested positive for 2nd time ANA 1:160 centromere on 3/4 n 4/5. Tested neg 4 sl-70. What additional test can be done to rule out crest/scleroderma?

See details: You keep asking the same question over and over again. There is no additional testing. You either have clinical symptoms consistent with the diagnosis or you do not. If you do not, then you do not have the diagnosis. ...Read more

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How many people die from scleroderma?

How many people die from scleroderma?

Rare disease: Scleroderma is a very rare autoimmune disease which often results in a progressive decline in health resulting in death, due to the fact that little or no treatment options exist for scleroderma. It is quite rare, among the rarest of all immune complex diseases. ...Read more

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What makes systemic scleroderma flare?

What makes systemic scleroderma flare?

Stress: There are no specific triggers to avoid if you have the condition. However, internal or external stress often precede a flare of scleroderma. ...Read more

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What are the 1st symptoms of scleroderma?

Tight skin: Early in the disease: fatigue, joint pain, tightening of the skin, and raynaud's phenomenon. ...Read more

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What are the possible symptoms of scleroderma?

Tight skin: Tight skin is characteristic but there can be a variety of other symptoms such as raynaud's, shortness of breath, chest pain, trouble swallowing, other GI symptoms, etc. Each person with scleroderma has a different set of symptoms and different type of scleroderma involvement. ...Read more

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What are the symptoms of scleroderma in a man?

The same like women: Scleroderma is a rare disease. Fewer than 500, 000 people in the United States have scleroderma. No one knows for sure why or how it develops. Some experts report that six out of seven patients are women. ...Read more

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If you get scleroderma, what are your symptoms?

If you get scleroderma, what are your symptoms?

Scleroderma symptoms: There are different types of sclerodema; one type may only be confined to the skin. Another type, called limited scleroderma, is frequently associated with food sticking or heart burn. Systemic sclerosis, the most severe, may be aassociated with shortness of breath with exertion, severe headache from very high blood pressure, weight loss from poor absorption of food, among others. ...Read more

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What is the definition or description of: Scleroderma?

Scleroderma: Scleroderma is an autoimmune disease and which there is excessive thickening of the connective tissues. This can cause skin tightening, rash, difficulty swallowing, and in severe cases affect kidneys and other organs. This is one disease in which a specialist such as a rheumatologist should be involved in your care. I am happy to do a consult if needed. ...Read more

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What are the first symptoms of someone with scleroderma has?

Scleroderma: Localised scleroderma (also known as morphoea). This only affects the skin. It causes some areas of the skin to become harder than usual. Systemic sclerosis. This causes some areas of the skin to become harder than usual, and it may involve one or more of the body's internal organs. Systemic sclerosis is an autoimmune disease.http://patient. Info/health/scleroderma-systemic-sclerosis ...Read more

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What is morphea also scleroderma?

What is morphea also scleroderma?

Sort of: Morphea is a localized patch of scleroderma (hard skin) that is generally not associated with the systemic manifestations of scleroderma or systemic sclerosis. ...Read more

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What is scleroderma crest variant?

Limited: The limited cutaneous form of systemic sclerosis is also referred to as crest syndrome. "crest" is an acronym for calcinosis, raynaud's syndrome, esophageal dysmotility, sclerodactyly, and telangiectasia. ...Read more

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What are the early signs of scleroderma?

What are the early signs of scleroderma?

Raynaud's Syndrome!: Raynaud's syndrome is most common, blanching of the last 2/3rds of the digits of the hand with cold, stress, or fear most common. Thickening of the skin of hands (sclerodactaly) is the second most common. Food sticking in the throat is another early sx. However some people can get early pulmonary or renal problems at the same time, or even before these other occur. If you have these, see a rheum. ...Read more

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Dr. Pierre Moeser
184 Doctors shared insights

Scleroderma (Definition)

An autoimmune disease in which there is excessive thickening of the connective tissues. This can cause skin tightening, rash, difficulty swallowing, and in severe cases affect ...Read more


Dr. Thomas Fiala
142 Doctors shared insights

Dermatosclerosis (Definition)

Dermatosclerosis = scleroderma = autoimmune disease affecting connective tissue & blood vessels. It causes skin to thicken asymmetrically due to deposits of fibrous connective ...Read more