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Doctor insights on: Anti Ro Ssa Antibodies

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Anti ro ssa was low but present. Anti TG antiTpo antibodies elevated but ana w/ panel was (-) euthyroid. Has s/s responds to plaquenil (hydroxychloroquine) Differential Dx?

Anti ro ssa was low but present. Anti TG antiTpo antibodies elevated but ana w/ panel was (-) euthyroid. Has s/s responds to plaquenil (hydroxychloroquine) Differential Dx?

Sjögren's syndrome: Anti-ssa antibodies are most commonly associated with Sjögren's syndrome, but it does not confirm a diagnosis. Pts should may have symptoms of dry eyes and dry mouth, which are classic for Sjögren's syndrome. These ab's are also associated with connective tissue diseases such as lupus or SLE. However, a pt must have clinical and lab abnormalities to meet the diagnosis.

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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Is anti-ro/ssa 60 associated with prolonged qt in adults, or only anti-ro 52?

Is anti-ro/ssa 60 associated with prolonged qt in adults, or only anti-ro 52?

In general no: The cardiac issues are in newborns from mothers who have these antibodies. The newborns get heartblock

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Is there a difference between anti-Ro/SSA 52-kd level and anti-Ro52/TRIM 21, or are they the same thing?

Is there a difference between anti-Ro/SSA 52-kd level and anti-Ro52/TRIM 21, or are they the same thing?

Same thing.: I believe you are running into a nomenclature problem, its essentially the same antibody protein, not to be confused with the Ro60 antibody, designated as SSA/60 sometimes. So the easy way to look at it is there are 2 SSA/Ro antibodies. 52 kd and 60 kd which have different clinical ramifications.

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If I am anti-Ro/SSA positive, is it safe for me to get the flu shot?

If I am anti-Ro/SSA positive, is it safe for me to get the flu shot?

I know of NO: REASONS why not!

Ask the Medical Professional who ordered this testing he/she will know your complete medical history and this is important in answering your question!

Hope this is helpful
Dr Z

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Pos ANA, SSA (RO)Antibody is 106 but ANA Titer is >1:40. My rheumy diagnosed Sjogrens & neuropathy based on symptoms/labs but the titer makes me wonder?

Second Opinion: Anti RO-SSA can be associated with more than ONE autoimmune diseases. Besides Sjorgen's, SLE (Lupus) or Cutaneous Lupus being other entities. This lab result MUST be interpreted with your CLINICAL history...no lab should ever be taken independent of symptoms and history. My advise is if you have reservations about accepting your current Rheumatologist conclusion seek a SECOND Opinion.

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Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa (ro), ssb (la), scl-70, centromere. Is this likely lupus or a different automimmune?

Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa (ro), ssb (la), scl-70, centromere. Is this likely lupus or a different automimmune?

Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor.

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What is the ssa/Ssb blot test antibody blood test?

What is the ssa/Ssb blot test antibody blood test?

A test: For a certain autoimmune condition. It's important to understand that these blood tests need to be interpreted carefully in the context of your symptoms and exam findings. A positive test doesn't necessarily mean you have the condition.

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The result of my SS-A/Ro Antibody, IgG, Serum is 1.6 and it says High. What could this mean? I have many lupus symptoms.

Indeterminate: Anti-SSa/Ro autoantibodies are present in about 0.1-0.5 percent of people. There is an association with lupus but also biliary cirrhosis and Sjögren's syndrome. If you have this and other symptoms if lupus, as u say, it is possible you have lupus. You should consult with the doctor who ordered the blood work to determine for sure the next steps. Good luck!

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I was diagnosed with Primary Sjögren syndrome over a year ago. Recent bloods show ANA over 1000. What does this mean? Ro and La antibodies positive

I was diagnosed with Primary Sjögren syndrome over a year ago. Recent bloods show ANA over 1000. What does this mean? Ro and La antibodies positive

Sjogrens: Sjogren syndrome is an arthritic disease. You can stay in remission or you can flare up often. How do you feel? The antibodies help make the diagnosis for you. Now if you have or in a flare up this too can be detected in the lab studies. Arthritic disease are diagnosed clinically so how you present and how you feel is important to express

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I'm anti-SSA antibody positive, but anti-SSB antibody negative. Could I still have Sjogrens?

I'm anti-SSA antibody positive, but anti-SSB antibody negative. Could I still have Sjogrens?

Perhaps.: The diagnosis of Sjogren’s is not made by blood testing positivity or negativity alone, but by an accurate and thorough history and physical examination first. If you have symptoms consistent with Sjogren’s, then you could have it regardless of the blood test results.

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My blood work came back with elevated ssa auto antibodies, high jo-1 autoantibodies and my complement total was high, what does this indicate?

My blood work came back with elevated ssa auto antibodies, high jo-1 autoantibodies and my complement total was high, what does this indicate?

Need more info: You need tell why the tests were ordered in the first place. What symptoms do you have? Test results cannot be accurately interpreted in a vacuum as ssa and jo-1 antibodies can be positive in normal on occasion. In general elevated complements mean nothing, jo-1 can be positive in anti-synthetase syndrome (look it up) and ssa positive in sle or sjogren's.

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What's the difference between the sjorgren ssa / ssb antibodies? Is a level of 2.7 for the ssb antibody high? Normal is 0-0.9. Also ANA pos/ ds DNA 6.

Autoantibodies: Directed against ro/ssa and la/ssb auto antigens were originally identified in patients with sjogren's and lupus. But can be present in others autoimmune diseases. Ro/ssa and la/ssb are different intracellular autoantigens from extractable nuclear antigens. Which are soluble cytoplasmic and nuclear components. You have an autoimmune disease. More clinical info needed for diagnosis. Rheumatologist.

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I was recently diagnosed with mild primary Sjögren's syndrome by my rheumatologist. I have a positive Ro antibody. What does this mean?

Autoimmune disease: Sjogrens is one where your body produces antibodies against certain tissues. It can affect the eyes, mouth, salivary glands, kidneys, liver, lungs, peripheral nerves etc. You need to be a Rheumatologist to begin with and if any further organ involvement is suspected that particular specialist should be seeing you. Dry eyes, dry mouth, parotid gland enlargement, kidney dz symptoms, even lymphoma +

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I have lupus- diagnosed w/labs and symptoms. But had no antibodies positive- all were 0 except my ssa was 8 (0-40 is neg) & scl-70 was 3 (0-40 neg) should I be concerned about scleroderma? Very scared!

Rheumatologist.. ..: You need to see a rheumatologist to sort out the lupus question. Lots of symptoms but zero lab evidence may not necessarily be lupus. Make sure diagnosis is right!

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Ana went from 1:80 spck to negative, VHS went from 50 to 10mm in 1week. Negative anti-dsDNA, Antibodies to Ro/SS-A and La/SS-B, RNP and SM. Lupus?

Ana went from 1:80 spck to negative, VHS went from 50 to 10mm in 1week. Negative anti-dsDNA, Antibodies to Ro/SS-A and La/SS-B, RNP and SM. Lupus?

Probably not: A low level ANA can be seen as a auto immune phenomenon of Hashimoto's thyroiditis (which I see you have). The specific lupus tests are (-). Joint pain without joint swelling is not a reliable diagnostic finding for lupus.