Doctor insights on:
Anti Ro Antibody
Ana went from 1:80 spck to negative, VHS went from 50 to 10mm in 1week. Negative anti-dsDNA, Antibodies to Ro/SS-A and La/SS-B, RNP and SM. Lupus?
Anti ro ssa was low but present. anti TG antiTpo antibodies elevated but ana w/ panel was (-) euthyroid.has s/s responds to plaquenil (hydroxychloroquine) Differential Dx?
Sjögren's syndrome: Anti-ssa antibodies are most commonly associated with Sjögren's syndrome, but it does not confirm a diagnosis. Pts should may have symptoms of dry eyes and dry mouth, which are classic for Sjögren's syndrome. These ab's are also associated with connective tissue diseases such as lupus or SLE. However, a pt must have clinical and lab abnormalities to meet the diagnosis. ...Read more
Will the results from immunological blood testing (anti-ro/ana/ena/dna) depend on my current health state?
No: Either you have these markers or not. Their presence is not dependent on health status ...Read more
I have mctd (+ana, rnp). Recent test when i was unwell + anti ro, sm/rnp, anti smooth muscle, antichromatin-low titres of most. What does all this mean? Is my disease progressive? I am terrified.
I was recently diagnosed with mild primary Sjögren's syndrome by my rheumatologist. I have a positive Ro antibody. What does this mean?
Autoimmune disease: Sjogrens is one where your body produces antibodies against certain tissues. It can affect the eyes, mouth , salivary glands, kidneys ,liver, lungs, peripheral nerves etc. You need to be a Rheumatologist to begin with and if any further organ involvement is suspected that particular specialist should be seeing you . Dry eyes, dry mouth, parotid gland enlargement ,kidney dz symptoms,even lymphoma + ...Read moreSee 1 more doctor answer
The result of my SS-A/Ro Antibody, IgG, Serum is 1.6 and it says High. What could this mean? I have many lupus symptoms.
Indeterminate: Anti-SSa/Ro autoantibodies are present in about 0.1-0.5 percent of people. There is an association with lupus but also biliary cirrhosis and Sjögren's syndrome. If you have this and other symptoms if lupus, as u say, it is possible you have lupus. You should consult with the doctor who ordered the blood work to determine for sure the next steps. Good luck! ...Read more
I have positive ANA sm, ssa (ro), ssb (la) , ro52, jo-1, sci-70, ribosomal p antibodies what are the levels for each antibody that signify lupus?
Levels not important: If the antibodies are positive, they are positive. The degree of positivity does not matter. ...Read more
I have positive ANA sm, ssa (ro), ssb (la) , ro52, jo-1, sci-70, ribosomal p antibodies what are the levels for each antibody that signify lupus ?
Level not important: If these antibodies are truly positive the degree of positivity is not that important. ...Read more
Pos ANA, SSA(RO)Antibody is 106 but ANA Titer is >1:40. My rheumy diagnosed Sjogrens & neuropathy based on symptoms/labs but the titer makes me wonder?
Second Opinion: Anti RO-SSA can be associated with more than ONE autoimmune diseases. Besides Sjorgen's, SLE (Lupus) or Cutaneous Lupus being other entities. This lab result MUST be interpreted with your CLINICAL history...no lab should ever be taken independent of symptoms and history. My advise is if you have reservations about accepting your current Rheumatologist conclusion seek a SECOND Opinion. ...Read more
Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?
Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read moreSee 1 more doctor answer
Used for diagnosis: of mixed connective tissue disease (generally scleroderma with lupus overlap and muscle inflammation) for which it is fairly specific (accurate). The action of the antibody is not well characterized and probably less important than its use for diagnostic purpose (we know it binds to a protein for RNA building). In patients with anti-centromere Ab+ scleroderma, it portends kidney complications. ...Read more
A warrior increase: Think of an antibody as a soldier to help you beat the enemy (infection) if you have increasing antibodies you have more warriors. The problem here is if the warriors decide to fight against your own body rather than infection. You then have an auto-immune disease like rheumatoid arthritis. ...Read more
From immune B cells: Antibodies, also called immunoglobulins or gamma-globulins, are made in a type of white blood cell called B-cells. They are in the blood stream, lymph nodes and in the bone marrow. We have 5 different types of antibodies: IgM (first responder), IgG (good long term immunity), IgA (in the mucous lining-tears, saliva, respiratory tract and intestinal tract), IgE (allergic antibody) and IgD (unknown) ...Read more
Meds or diseases: There are many reasons. Immune suppressant medications (e.g. steroids, azathioprine, mycophenolate), chemotherapy, certain seizure meds can all cause low antibody levels. Also, immune deficiencies like CVID lead to low levels. Certain infections like HIV can cause it, too. Excessive loss of protein from chronic diarrhea can cause it. Talk with an immunologist if you have more questions. ...Read more
A test found that i don't have brusselosis , but I do have brusselosis antibodies , should I be alarmed ? What's the risk? What should I do?
Genetics: You're talking about blood group antigens; sugars on the outside of the red blood cells unique to those with certain blood types. Those who have sugars "A" and "B" should not develop antibodies to these sugars, or else such antibodies would "attack" their own red blood cells (triggering lysis). ...Read more
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