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Doctor insights on: Anti Rnp Antibody Test

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If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus. All this needs to be correlated by your doc/specialist

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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Given a positive RNP antibody test, what are the clinical diagnostic criteria for MCTD?

Given a positive RNP antibody test, what are the clinical diagnostic criteria for MCTD?

MCTD: Usually considered diagnostic if high RNP titer, and two or more of the following: Raynauds, myositis, synovitis and swollen fingers/hands.

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Had lab test done. Sm/rnp antibody 2.5 pos. What does this mean?

Had lab test done. Sm/rnp antibody 2.5 pos. What does this mean?

Probably nothing: That low titer is not impressive, usually the RNP. Ask the doctor who ordered it. Why was the test ordered in the first place?

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Can there be false positive rnp antibody tests even with a high titre of an ana?

Can there be false positive rnp antibody tests even with a high titre of an ana?

FALSE POSITIVE RNP: It is possible we need to know what your symptoms and signs are, and why the tests have been ordered. The lab test apways have to be interpreted along with complete clinacal findings if you have signs and symptoms of lupus, high ana, and doctor ordered rnp to confirm the diagnosis and it comes out positive. That in all probabilities is positive and not false positive.

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What is the definition or description of: rnp antibody?

What is the definition or description of: rnp antibody?

Anti-RNP: Http://www. Mayomedicallaboratories. Com/test-catalog/clinical+and+interpretive/81357.

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I was just diagnosd with mctd...No symptoms just rnp antibody of 1.9 and anachoice screen-positive...What lies ahead for me?

I was just diagnosd with mctd...No symptoms just rnp antibody of 1.9 and anachoice screen-positive...What lies ahead for me?

Diagnosis?: Connective tissue diseases can only be diagnosed if a person has symptoms and physical signs of a disease. Mctd cannot be diagnosed by blood test alone as a percent of the normal population has a positive rnp without any disease. It is not like checking your blood type (a positive, o negative, etc.). Ask your doctor how the diagnosis of mctd was made.

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I'm having negative DNA, Sm and Rnp antibodies, but positive sm/rnp antibody, and high ANA titre speckled, so what is the diagnosis?

I'm having negative DNA, Sm and Rnp antibodies, but positive sm/rnp antibody, and high ANA titre speckled, so what is the diagnosis?

Lupus: These serologies are rather non specific. The speckled ANA is non specific. In Systemic Lupus Erythematosis (SLE) it is usually homogeneous in its staining. Anti-Sm and Anti RNP can be see in mixed connective-tissue diseases and overlaps with SLE, scleroderma and myositis. As often is the case a specific diagnosis cannot be made. You need to see a Rheumatologist.

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Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Heads up: One of the things that's frustrating about these antibody tests looking for different connective tissue diseases is that they are difficult to do and are fraught with pitfalls. I suspect you've had at least one lab error to complicate your workup. Have you have a tube test for u1-rnp? Your clinical symptoms and signs actually tell more about your diagnosis ; best direction for treatment.

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I was just diagnosd with mctd rnp antibody of 1.9 and anachoice screen-positive the only symptom is joint pain in my hand/wrist (i do have carpal tnl?

I was just diagnosd with mctd rnp antibody of 1.9 and anachoice screen-positive the only symptom is joint pain in my hand/wrist (i do have carpal tnl?

Positive Labs: Positive labs are meaningless unless you have symptoms. At this point, your doctor is aware of the positive results and will likely follow your symptoms. The positive simply means you are at a greater chance of developing symptoms though not everybody does.

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Went to dr with hand, shoulder, hip joint pain. Ana reflex screen Ana positive 1.0 and rnp antibody positive 4.3. All others neg. Very scared!

Went to dr with hand, shoulder, hip joint pain. Ana reflex screen Ana positive 1.0 and rnp antibody positive 4.3. All others neg. Very scared!

Lab numbers: These numbers don't show changes at joints and with most auto immune disorders, you may have periods of pain and increased lab numbers, usually related to stress in your life, and once treated medically or with stress reduction, pain/lab should improve. May want xray of one of involved joints just inflamed which can return to baseline.

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After sore throat, blood panel revealed infection and possible mono. Only other off number was rnp antibody of 5.8. Ana of 5. Could mono cause uprnp?

After sore throat, blood panel revealed infection and possible mono. Only other off number was rnp antibody of 5.8. Ana of 5. Could mono cause uprnp?

No.: Your serologies suggest mctd, or mixed connective tissue disease. This is much milder than systemic lupus erythematosis, and in 28 years, I have never had a dire situation with any patient with this DX alone. There is no relationship with mononucleosus. Most patients are treated with hydroxycholorquine or low dose prednisone. Aches and pains: aleve! don't worry about it!

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I've had pain in my joints, I got blood tests related to autoimmune diseases I got a positive ANA and anti-rnp, is this found in rheumatoid arthritis?

Possible: You should ask your rheumatologist. ANA and anti-RNP are seeing in mixed connective tissue disease and can overlap with rheumatoid arthritis but more information is needed, talk to your rheumatologist about them. RA by itself usually have other 2 antibodies positive called RF (rheumatoid factor) and anti-CCP (citrullinated peptides).

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Is a value of <10 CU on anti-Sm and anti-RNP mean these autoantibodies do not exist at all (I.e. 0)? Or that there's only a very low concentration? Yt

Is a value of <10 CU on anti-Sm and anti-RNP mean these autoantibodies do not exist at all (I.e. 0)? Or that there's only a very low concentration? Yt

Immunology tests: Normal / abnormal ranges of anti-sm and anti-RNP depend on the laboratory used and technique (like ELISA). Analyze results according to guidelines of the laboratory running the sample; they report normal, borderline, & positive ranges. Example: one lab running an ELISA will report a negative anti-RNP result defined as

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Can you please discuss the relationship among sle, mctd, anas, anti-rnp, myalgia, and myositis? How common is it to find these concurrent in a person?

Very common: These are all autoimmune diseases due to loss of regulation on the immune system and thus they often occur in combination or individually.

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Doctor, in Anti-ENA screen, my Anti RNP and Anti Sm are both low positive. I have dry eyes and dry mouth symptons. What dieseae it could be? Thanks!

Doctor, in Anti-ENA screen, my Anti RNP and Anti Sm are both low positive. I have dry eyes and dry mouth symptons. What dieseae it could be? Thanks!

Sjogren's syndrome: Positive Anti-nuclear antibodies (ie Anti RNP, anti SM) can be a hallmark of the systemic autoimmune diseases, Dry eyes can cause chronic eye pain. If you also have a dry mouth & arthritis, ask your eyemd or md to evaluate specifically for Sjogren's syndrome.

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I had a ANA test done everything came back good beside rnp antibodies. Value 1.8 reference range 0.0-0.9. Everything else was good is this bad.

It is barely positiv: So results must be interpreted very carefully with all clinical symptoms taken into account. A test by itself is just a test. You might need a good rheumatologist

Dr. Milroy Samuel
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Rnp Antibody (Definition)

Http://www. Mayomedicallaboratories. Com/test-catalog/clinical+and+interpretive/81357. ...Read more