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Doctor insights on: Anti Rnp Antibodies

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If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do?  (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus.All this needs to be correlated by your doc/specialist ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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Is a value of <10 CU on anti-Sm and anti-RNP mean these autoantibodies do not exist at all (I.e. 0)? Or that there's only a very low concentration? Yt

Is a value of <10 CU on anti-Sm and anti-RNP mean these autoantibodies do not exist at all (I.e. 0)? Or that there's only a very low concentration?
Yt

Immunology tests: Normal / abnormal ranges of anti-sm and anti-RNP depend on the laboratory used and technique (like ELISA). Analyze results according to guidelines of the laboratory running the sample; they report normal, borderline, & positive ranges. Example: one lab running an ELISA will report a negative anti-RNP result defined as ...Read more

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Can you please discuss the relationship among sle, mctd, anas, anti-rnp, myalgia, and myositis? How common is it to find these concurrent in a person?

Can you please discuss the relationship among sle, mctd, anas, anti-rnp, myalgia, and myositis? How common is it to find these concurrent in a person?

Very common: These are all autoimmune diseases due to loss of regulation on the immune system and thus they often occur in combination or individually. ...Read more

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Doctor, in Anti-ENA screen, my Anti RNP and Anti Sm are both low positive. I have dry eyes and dry mouth symptons. What dieseae it could be? Thanks!

Doctor, in  Anti-ENA screen, my Anti RNP and Anti Sm are both low positive. I have dry eyes and dry mouth symptons. What dieseae it could be? Thanks!

Sjogren's syndrome: Positive Anti-nuclear antibodies(ie Anti RNP, anti SM) can be a hallmark of the systemic autoimmune diseases, Dry eyes can cause chronic eye pain. If you also have a dry mouth & arthritis, ask your eyemd or md to evaluate specifically for Sjogren's syndrome. ...Read more

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I've had pain in my joints, I got blood tests related to autoimmune diseases I got a positive ANA and anti-rnp, is this found in rheumatoid arthritis?

Possible: You should ask your rheumatologist. ANA and anti-RNP are seeing in mixed connective tissue disease and can overlap with rheumatoid arthritis but more information is needed, talk to your rheumatologist about them. RA by itself usually have other 2 antibodies positive called RF ( rheumatoid factor) and anti-CCP ( citrullinated peptides). ...Read more

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What is the definition or description of: rnp antibody?

What is the definition or description of: rnp antibody?

Anti-RNP: http://www.mayomedicallaboratories.com/test-catalog/clinical+and+interpretive/81357.

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Does it matter what the titre of rnp antibodies are when it is the only single one identified in diagnosing mixed connective tisseue disease?

Does it matter what the titre of rnp antibodies are when it is the only single one identified in diagnosing  mixed connective tisseue disease?

No: The diagnosis of mctd must first be made if the history and physical examination are indicative of a possible connective tissue disease. If those elements are present and the disease seems to overlap between conditions such as lupus and polymyositis and others, it is reasonable to do laboratory testing. Only then, if the rnp is above the reference lab normal, it will confirm mctd. Rnp alone: no dx. ...Read more

Dr. Peter Ihle
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Rnp Antibody (Definition)

http://www.mayomedicallaboratories.com/test-catalog/clinical+and+interpretive/81357. ...Read more