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Doctor insights on: Anti Rnp Antibodies

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If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do?  (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus.All this needs to be correlated by your doc/specialist ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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Is a value of <10 CU on anti-Sm and anti-RNP mean these autoantibodies do not exist at all (I.e. 0)? Or that there's only a very low concentration? Yt

Is a value of <10 CU on anti-Sm and anti-RNP mean these autoantibodies do not exist at all (I.e. 0)? Or that there's only a very low concentration?
Yt

Immunology tests: Normal / abnormal ranges of anti-sm and anti-RNP depend on the laboratory used and technique (like ELISA). Analyze results according to guidelines of the laboratory running the sample; they report normal, borderline, & positive ranges. Example: one lab running an ELISA will report a negative anti-RNP result defined as ...Read more

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Can you please discuss the relationship among sle, mctd, anas, anti-rnp, myalgia, and myositis? How common is it to find these concurrent in a person?

Can you please discuss the relationship among sle, mctd, anas, anti-rnp, myalgia, and myositis? How common is it to find these concurrent in a person?

Very common: These are all autoimmune diseases due to loss of regulation on the immune system and thus they often occur in combination or individually. ...Read more

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Doctor, in Anti-ENA screen, my Anti RNP and Anti Sm are both low positive. I have dry eyes and dry mouth symptons. What dieseae it could be? Thanks!

Doctor, in  Anti-ENA screen, my Anti RNP and Anti Sm are both low positive. I have dry eyes and dry mouth symptons. What dieseae it could be? Thanks!

Sjogren's syndrome: Positive Anti-nuclear antibodies(ie Anti RNP, anti SM) can be a hallmark of the systemic autoimmune diseases, Dry eyes can cause chronic eye pain. If you also have a dry mouth & arthritis, ask your eyemd or md to evaluate specifically for Sjogren's syndrome. ...Read more

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I've had pain in my joints, I got blood tests related to autoimmune diseases I got a positive ANA and anti-rnp, is this found in rheumatoid arthritis?

Possible: You should ask your rheumatologist. ANA and anti-RNP are seeing in mixed connective tissue disease and can overlap with rheumatoid arthritis but more information is needed, talk to your rheumatologist about them. RA by itself usually have other 2 antibodies positive called RF ( rheumatoid factor) and anti-CCP ( citrullinated peptides). ...Read more

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What is the definition or description of: rnp antibody?

What is the definition or description of: rnp antibody?

Anti-RNP: http://www.mayomedicallaboratories.com/test-catalog/clinical+and+interpretive/81357.

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Does it matter what the titre of rnp antibodies are when it is the only single one identified in diagnosing mixed connective tisseue disease?

Does it matter what the titre of rnp antibodies are when it is the only single one identified in diagnosing  mixed connective tisseue disease?

No: The diagnosis of mctd must first be made if the history and physical examination are indicative of a possible connective tissue disease. If those elements are present and the disease seems to overlap between conditions such as lupus and polymyositis and others, it is reasonable to do laboratory testing. Only then, if the rnp is above the reference lab normal, it will confirm mctd. Rnp alone: no dx. ...Read more

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Given a positive RNP antibody test, what are the clinical diagnostic criteria for MCTD?

Given a positive RNP antibody test, what are the clinical diagnostic criteria for MCTD?

MCTD: Usually considered diagnostic if high RNP titer, and two or more of the following: Raynauds, myositis, synovitis and swollen fingers/hands. ...Read more

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What does a weakly positive ANA with only rnp antibodies indicate?

Specific to patient: The test by itself is not diagnostic.. It depends on your evaluation, examination, clinical factors are the most pertinent. The lab reports are guidelines but not diagnostic in themselves. ...Read more

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Had lab test done. Sm/rnp antibody 2.5 pos. What does this mean?

Had lab test done.  Sm/rnp antibody   2.5 pos.   What does this mean?

Probably nothing: That low titer is not impressive, usually the RNP. Ask the doctor who ordered it. Why was the test ordered in the first place? ...Read more

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Can there be false positive rnp antibody tests even with a high titre of an ana?

FALSE POSITIVE RNP: It is possible we need to know what your symptoms and signs are, and why the tests have been ordered.The lab test apways have to be interpreted along with complete clinacal findings if you have signs and symptoms of lupus, high ana, and doctor ordered rnp to confirm the diagnosis and it comes out positive.That in all probabilities is positive and not false positive. ...Read more

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I was just diagnosd with mctd...No symptoms just rnp antibody of 1.9 and anachoice screen-positive...What lies ahead for me?

I was just diagnosd with mctd...No symptoms just rnp antibody of 1.9  and anachoice screen-positive...What lies ahead for me?

Diagnosis?: Connective tissue diseases can only be diagnosed if a person has symptoms and physical signs of a disease. Mctd cannot be diagnosed by blood test alone as a percent of the normal population has a positive rnp without any disease. It is not like checking your blood type (a positive, o negative, etc.). Ask your doctor how the diagnosis of mctd was made. ...Read more

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I had a ANA test done everything came back good beside rnp antibodies. Value 1.8 reference range 0.0-0.9. Everything else was good is this bad.

It is barely positiv: So results must be interpreted very carefully with all clinical symptoms taken into account. A test by itself is just a test. You might need a good rheumatologist ...Read more

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I have been reading online and have read that when the rnp is the only antibody that is positive that this indicated mixed connective tissue disease?

I have been reading online and have read that when the rnp is the only antibody that is positive that this indicated mixed connective tissue disease?

Labs can confuse.: The labs are just a fraction of what needed to get you better. Your history and physical exam will determine your treatment. Looking for which labs will delay and confuse. You need to develop a few paragraphs of all your issues and sit down with your doctor to put the pieces together. Began a wellness program and add in magnesium and acupuncture. ...Read more

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I'm having negative DNA ,Sm and Rnp antibodies, but positive sm/rnp antibody,and high ANA titre speckled,so what is the diagnosis ?

Lupus: These serologies are rather non specific. The speckled ANA is non specific. In Systemic Lupus Erythematosis (SLE) it is usually homogeneous in its staining. Anti-Sm and Anti RNP can be see in mixed connective-tissue diseases and overlaps with SLE, scleroderma and myositis. As often is the case a specific diagnosis cannot be made. You need to see a Rheumatologist. ...Read more

Dr. Peter Ihle
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Rnp Antibody (Definition)

http://www.mayomedicallaboratories.com/test-catalog/clinical+and+interpretive/81357. ...Read more