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Doctor insights on: Anti Rnp

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Dr. Ana Adelstein
80 doctors shared insights

Rnp Antibody (Definition)

http://www.mayomedicallaboratories.com/test-catalog/clinical+and+interpretive/81357. ...Read more


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Anti thryroglobulin anti level 14.9 ?anti microsomal ab level 77?

Anti thryroglobulin anti level 14.9 ?anti microsomal ab level 77?

Elevated: Hi. In the labs I know, those levels would be above normal, indicating an autoimmune process in the thyroid. They do not imply anything about thyroid function, and can be seen elevated in hyperthyroidism, hypothyroidism, and with normal thyroid function. If your thyroid function is abnormal, those antibodies would imply an autoimmune etiology. ...Read more

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Anti ro ssa was low but present. anti TG antiTpo antibodies elevated but ana w/ panel was (-) euthyroid.has s/s responds to plaquenil (hydroxychloroquine) Differential Dx?

Anti ro ssa was low but present. anti TG antiTpo antibodies elevated but ana w/ panel was (-) euthyroid.has s/s responds to plaquenil (hydroxychloroquine) Differential Dx?

Sjögren's syndrome: Anti-ssa antibodies are most commonly associated with Sjögren's syndrome, but it does not confirm a diagnosis. Pts should may have symptoms of dry eyes and dry mouth, which are classic for Sjögren's syndrome. These ab's are also associated with connective tissue diseases such as lupus or SLE. However, a pt must have clinical and lab abnormalities to meet the diagnosis. ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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Please interpret this HBsAG reactive, anti hbs non-reactive, hbeag non-reactive, anti hbe reactive, anti hbc (igm) nonreactive, anti hbc total reactiv?

Please interpret this HBsAG reactive, anti hbs non-reactive, hbeag non-reactive, anti hbe reactive, anti hbc (igm) nonreactive, anti hbc total reactiv?

Hep B: It means you were exposed to the virus in the past and you don't have an acute infection. Despite that you did not develop the immunity and you can still be reinfected. You are not highly contagious yourself, i still suggest you partner and family should get vaccinated. ...Read more

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Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Heads up: One of the things that's frustrating about these antibody tests looking for different connective tissue diseases is that they are difficult to do and are fraught with pitfalls. I suspect you've had at least one lab error to complicate your workup. Have you have a tube test for u1-rnp? Your clinical symptoms and signs actually tell more about your diagnosis ; best direction for treatment. ...Read more

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I have joint pain and sometimes feel fever,twitching. Ana 1:40 but Rf, anti ccp , anti dna, anti sm,crp, Esr, scl-70 are negative, autoimmune disease?

I have joint pain and sometimes feel fever,twitching. Ana 1:40 but Rf, anti ccp , anti dna, anti sm,crp, Esr, scl-70 are negative, autoimmune disease?

Consultation advised: Unfortunately, Medicine is much too complicated to be able to give helpful advice on the basis of such limited information. An IN BOX Text consultation at Health Tap may be helpful.You would need to upload results of any tests, if available, as well as your medical history. You would NEED TO MAKE YOURSELF AVAILABLE for 24 hours to reply to any questions from your consultant.http://bit.ly/1OiIRcI ...Read more

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Pls interpret: HBsAG w/Titer 4548.07 Reactive. Anti HBS NONREACTIVE, HBeAG NONREACTIVE, Anti HBe REACTive, Anti HBc IgM NONREACTIVE?

Pls interpret: HBsAG w/Titer 4548.07 Reactive. Anti HBS NONREACTIVE, HBeAG NONREACTIVE, Anti HBe REACTive, Anti HBc IgM NONREACTIVE?

Chronic hepatitis B: This pattern of serology is consistent with chronic hepatitis B infection, which often leads to fatal cirrhosis and/or liver cancer. Consultation with a gastroenterologist with an interest is liver disease is recommended. ...Read more

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Ana and anti ds DNA positive, but no symptom?

Ana and anti ds DNA positive, but no symptom?

See below: These can be false positives. See a rheumatologist for evaluation to determine if that is the case. ...Read more

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Kindly interpret HBsAg reactive, anti HBs non reactive, HBeAg non reactive, Anti HBe recative,Anti HBc IgM non reactive?

Kindly interpret HBsAg reactive, anti HBs non reactive, HBeAg non reactive, Anti HBe recative,Anti HBc IgM non reactive?

Hepatitis B: Because you have Hepatitis B surface antigen (HBsAg) present, that means you have hepatitis B in your liver. I wonder if you have any symptoms -such as turning yellow? In the Philippines there is a high prevalence of hepatitis B, and many people were infected at the time of birth. The other lab findings seem to suggest that. Hope you can see a ID doctor there or GI doctor for treatment. God bless ...Read more

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Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?

Blood tests showed high  antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere.  Is this likely lupus or a different automimmune?

Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read more

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If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do?  (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus.All this needs to be correlated by your doc/specialist ...Read more

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ANA 1:160 homogenous, anti ssDNA 42, normal Rh factor, ESR, anti dsDNA , neg HLA B27. Tests due to severe joint pain- is this indicative of lupus??

ANA 1:160 homogenous, anti ssDNA 42, normal Rh factor, ESR, anti dsDNA , neg HLA B27. Tests due to severe joint pain- is this indicative of lupus??

Might be.: These labs do not rule lupus out nor do they rule it in. I think your doc should keep looking and monitor your progress over time. Depending upon joints could represent parvovirus although that is just a wild guess. Your clinical picture and progress is most important. ...Read more

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Coexistence of hbsag and anti hbs?

Coexistence of hbsag and anti hbs?

It's possible.: When HBsAg and HBsAb are detected simultaneously, the first thing to do is to recheck the labs to be sure it is not in error. If it is confirmed, it is a rare instance of a mutation in the HBsAg region, and there is not good data about the response to conventional therapies. Be sure you were seeing an experienced hepatologist if this is present. Good luck. ...Read more

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Please interpret my hepatitis b profile result: thanks HBsAg - reactive ANTI HBs- non-reactive ANTI HAV IgM- non-reactive HBeAg- non-reactive ANTI HBe?

Please interpret my hepatitis b profile result: thanks
HBsAg - reactive
ANTI HBs- non-reactive
ANTI HAV IgM- non-reactive
HBeAg- non-reactive
ANTI HBe?

Hep B testing: You need to have your doctor repeat the testing for confirmation because as it stands right now, you are currently positive for Hepatitis B although it does not show you as infectious to others. Nevertheless, these are rudimentary labs that need to be addressed by your primary doctor for further clarification. ...Read more

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Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?

Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?

POSSIBLE: Your lab outcomes plus the prior DVT, seem consistent, but other labs may further assist such as changes in PTT. Might get additional opinion to confirm your diagnosis, and exclude other problems, but certainly antiphospholipid antibody syndrome seems high on list. ...Read more

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Anti microsomal antibody is -191 and anti thyroglobulin antibody is-236.1 iu/ml what does it mean , suggest medicines?

Anti microsomal antibody is -191 and anti thyroglobulin antibody is-236.1 iu/ml what does it mean , suggest medicines?

Autoimmune: These antibody titers point to the presence of an autoimmune process which makes you at a higher risk of getting thyroid disease. Need to know what your thyroid function is and what kinds of symptoms you have before any suggestion on treatment can be made. Shouldn't you be talking to the doctor who ordered these tests? ...Read more

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What would diagnosis be with test results 1:160 ANA- Positive-Speckl C4 Complement- 13 mg Anti-DS-DNA - 3 IU SM antib- 7 Index RNP Anti-5 SS-A-3

Part of the picture: those lab results should be put in perspective, what are the symptoms and signs present, the best to judge / give a diagnosis is the doctor who ordered the blood tests, all these results can just be insignificant in absence of other criteria, best wishes ...Read more

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Anti tpo antibodies 1300. What does this mean?

Hashimotos: This would suggest autoimmune thyroid disease, either hashimotos thyroiditis or graves disease. But it is not diagnostic. See your endocrinologist. ...Read more

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Is a value of <10 CU on anti-Sm and anti-RNP mean these autoantibodies do not exist at all (I.e. 0)? Or that there's only a very low concentration? Yt

Is a value of <10 CU on anti-Sm and anti-RNP mean these autoantibodies do not exist at all (I.e. 0)? Or that there's only a very low concentration?
Yt

Immunology tests: Normal / abnormal ranges of anti-sm and anti-RNP depend on the laboratory used and technique (like ELISA). Analyze results according to guidelines of the laboratory running the sample; they report normal, borderline, & positive ranges. Example: one lab running an ELISA will report a negative anti-RNP result defined as ...Read more

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Can you please discuss the relationship among sle, mctd, anas, anti-rnp, myalgia, and myositis? How common is it to find these concurrent in a person?

Very common: These are all autoimmune diseases due to loss of regulation on the immune system and thus they often occur in combination or individually. ...Read more

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Doctor, in Anti-ENA screen, my Anti RNP and Anti Sm are both low positive. I have dry eyes and dry mouth symptons. What dieseae it could be? Thanks!

Doctor, in  Anti-ENA screen, my Anti RNP and Anti Sm are both low positive. I have dry eyes and dry mouth symptons. What dieseae it could be? Thanks!

Sjogren's syndrome: Positive Anti-nuclear antibodies(ie Anti RNP, anti SM) can be a hallmark of the systemic autoimmune diseases, Dry eyes can cause chronic eye pain. If you also have a dry mouth & arthritis, ask your eyemd or md to evaluate specifically for Sjogren's syndrome. ...Read more

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I've had pain in my joints, I got blood tests related to autoimmune diseases I got a positive ANA and anti-rnp, is this found in rheumatoid arthritis?

Possible: You should ask your rheumatologist. ANA and anti-RNP are seeing in mixed connective tissue disease and can overlap with rheumatoid arthritis but more information is needed, talk to your rheumatologist about them. RA by itself usually have other 2 antibodies positive called RF ( rheumatoid factor) and anti-CCP ( citrullinated peptides). ...Read more

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ANA was 1:320, nuclear coarse speckled. Anti-RNP 1.3. Likely scleroderma or MCTD or lupus? Only chest pain and mild acid reflux. 28 female.

ANA was 1:320, nuclear coarse speckled. Anti-RNP 1.3. Likely scleroderma or MCTD or lupus? Only chest pain and mild acid reflux. 28 female.

The diagnosis of: Connective tissue disorders is tricky and mainly clinical. Antibodies help in the classification but lupus, scleroderma and MCTD are all diseases with a spectrum of clinical manifestations. Many people meet criteria for more than one autoimmune disease. Treatment typically involves biological agents, steroids, and other immunosuppressants. Ask your rheumatologist what your specific diagnosis is. ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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What would diagnosis be with test results 1:160 ANA- Positive-Speckl C4 Complement- 13 mg Anti-DS-DNA - 3 IU SM antib- 7 Index RNP Anti-5 SS-A-3

Part of the picture: those lab results should be put in perspective, what are the symptoms and signs present, the best to judge / give a diagnosis is the doctor who ordered the blood tests, all these results can just be insignificant in absence of other criteria, best wishes ...Read more

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My rnp anti bodies was 1.8 and range the is 0.0-0.9. The rest of my ANA was neg. Besides anti centromere b was 0.2 range is 0.0-0.9. No mctd hopefuly?

ANAs are complex: ANA panels are complex and difficult to interpret. Clinal correlation with the results and the patterns of positivity and negativity are vital, as no ANA test is 100% sensitive or specific for any one entity. An assessment by a clinician who has experience with collagen vascular diseases in general may be helpful. ...Read more

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Why are my rf and my sm-rnp positive in my labs?

Why are my rf and my sm-rnp positive in my labs?

Several possibilitie: Positive smith and rnp antibodies indicate a propensity for systemic lupus. You have the disease, not on the basis of these tests, but if you have features of the illness. A positive rheumatoid factor does not itself indicate rheumatoid arthritis, since it can be positive in many autoimmune dsiseases. You should have a ccp antibody checked, as well as a c2 and c4 level. ...Read more

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What are considered high titres of rnp in the blood?

What are considered high titres of rnp in the blood?

Caution: Though lupus and mixed connective tissue disease are two conditions in which a person may have a positive rnp antibody, you cannot make a reverse assumption. In other words, a positive rnp does not diagnose a particular disease. I often consult on patients that have a positive ana, a positive rnp, etc. With no disease whatsoever. With rnp, high or low positive is dependent on the testing lab. ...Read more

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What does a elevated rf and a elevated sm rnp mean ?

What does a elevated rf and a elevated sm rnp mean ?

Autoimmune tests: These are blood tests that sometimes ordered to check for certain autoimmune diseases. They must always be interpreted in the context of a patient's symptoms. Sometimes they are positive, and have no connection to the person's symptoms. Rf is associated with rheumatoid arthritis but can also be positive in other conditions. Sm is associated with lupus; rnp w/ mixed connective tissue disease. ...Read more

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Is it possible to have a positive RNP (slight elevation. Dr. Said high but not high enough) and have it just be fibromyalgia as the cause?

Is it possible to have a positive RNP (slight elevation. Dr. Said high but not high enough) and have it just be fibromyalgia as the cause?

FIBROMYALGIA LAB EVA: Yes, Fibromyalgia is a diagnosis of exclusion . Topical Ultrasound usually relieves pain by improving blood flow to tender muscles. You need a second opinion labs recheck. X-ray and potential MRI If symptoms persist or worsen. Start a gluten free diet(whole approach.com/gutbliss.com) MEDS: Savella/Cymbalta/Lyrica. Supplements MG/UBIQUINOL/RESVERETROL. sleep study reveals Excess Alpha&lo REM ...Read more

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Since 2.5yrs i did 4 rnp tests. 1st 1.0, 2nd 1.1, 3rd 1.5 4th 1.7. U1-rnp >0.2. Other results >0.2 (as in my history). Why is rnp raising? No symptoms

Since 2.5yrs i did 4 rnp tests. 1st 1.0, 2nd 1.1, 3rd 1.5 4th 1.7. U1-rnp >0.2. Other results >0.2 (as in my history). Why is rnp raising? No symptoms

Why was test perform: Why was test performed? If no symptoms... First, these tests can be positive in normal individuals. Second, there does not seem to be a significant relationship of titer/level to disease or disease activity and further, these results may be within normal variation of the testing. ...Read more