Doctor insights on:
If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)
? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus.All this needs to be correlated by your doc/specialist ...Read more
What to do if I had six monthes ago an ANA test that is 1:80 positive, and border anti-rnp, but negative u1-rnp. I made a c?
Nothing: None of those results were impressive. Why were the tests ordered in the first place? ...Read more
Is a value of <10 CU on anti-Sm and anti-RNP mean these autoantibodies do not exist at all (I.e. 0)? Or that there's only a very low concentration?
Immunology tests: Normal / abnormal ranges of anti-sm and anti-RNP depend on the laboratory used and technique (like ELISA). Analyze results according to guidelines of the laboratory running the sample; they report normal, borderline, & positive ranges. Example: one lab running an ELISA will report a negative anti-RNP result defined as ...Read more
Can you please discuss the relationship among sle, mctd, anas, anti-rnp, myalgia, and myositis? How common is it to find these concurrent in a person?
Very common: These are all autoimmune diseases due to loss of regulation on the immune system and thus they often occur in combination or individually. ...Read more
Doctor, in Anti-ENA screen, my Anti RNP and Anti Sm are both low positive. I have dry eyes and dry mouth symptons. What dieseae it could be? Thanks!
Sjogren's syndrome: Positive Anti-nuclear antibodies(ie Anti RNP, anti SM) can be a hallmark of the systemic autoimmune diseases, Dry eyes can cause chronic eye pain. If you also have a dry mouth & arthritis, ask your eyemd or md to evaluate specifically for Sjogren's syndrome. ...Read moreSee 1 more doctor answer
I've had pain in my joints, I got blood tests related to autoimmune diseases I got a positive ANA and anti-rnp, is this found in rheumatoid arthritis?
Possible: You should ask your rheumatologist. ANA and anti-RNP are seeing in mixed connective tissue disease and can overlap with rheumatoid arthritis but more information is needed, talk to your rheumatologist about them. RA by itself usually have other 2 antibodies positive called RF ( rheumatoid factor) and anti-CCP ( citrullinated peptides). ...Read more
I have positive ANA with positive anti-rnp antibodies 6.8. Extreme fatigue, joint pain, low grade fevers and profound weakness. Saw rheumatologist who said it was fibromyalgia and that positive RNP "means nothing." what are your thoughts?
ANA was 1:320, nuclear coarse speckled. Anti-RNP 1.3. Likely scleroderma or MCTD or lupus? Only chest pain and mild acid reflux. 28 female.
The diagnosis of: Connective tissue disorders is tricky and mainly clinical. Antibodies help in the classification but lupus, scleroderma and MCTD are all diseases with a spectrum of clinical manifestations. Many people meet criteria for more than one autoimmune disease. Treatment typically involves biological agents, steroids, and other immunosuppressants. Ask your rheumatologist what your specific diagnosis is. ...Read more
What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?
Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more
What would diagnosis be with test results 1:160
C4 Complement- 13 mg
Anti-DS-DNA - 3 IU
SM antib- 7 Index
Part of the picture: those lab results should be put in perspective, what are the symptoms and signs present, the best to judge / give a diagnosis is the doctor who ordered the blood tests, all these results can just be insignificant in absence of other criteria, best wishes ...Read more