Doctor insights on:
Anti Rejection Drug
Depends: There are certain anti-rejection meds with significant drug-drug interaction that makes it necessary to take them separately. A good example is cyclosporine and sirolimus and one needs to take them separately (usually 4 hrs apart). I encourage you to speak to your transplant physicians/nurse coordinators for detailed information. ...Read more
Is it safe to stop anti rejection drugs for organ transplant after 3 years since no complications developed?
People have anti-rejection drugs for organ replacement why can't you have the same for blood transfusions?
It's not necessary: Rejection of a blood transfusion is called a "transfusion reaction." blood banks can almost always find a donor blood product which won't cause a reaction so anti-rejection drugs are usually not required. ...Read more
NO: The grafting material, unless it is your own bone, usually only provide a scaffold for your blood vessel to proliferating and bring in your own bone cell, differentiate, and mature into your bone. Anti rejection drug applied more for using a live graft (an organ, bone marrow, etc.) and assuming its function. Thus anti rejection drug is not prescribed for bone graft procedure. ...Read more
Not impossible: Talk with your physicians to let them know the details and perhaps they can make changes that will help. Absolutely do not change your dose or medication without doctor's advice. Promise? Be well! ...Read more
Safer than Rejection: All medicines have side effects. It's the job of the transplant clinic to find the right cocktail for each patient which will prevent rejection with minimal side-effects. Because most patients are on combination therapy, there is a great deal of art as well as science which goes into finding the best combination of drugs. ...Read more
Depends: If you miss just one dose of anti-rejection meds, the risk of that precipitating a rejection is likely low. However, it is the repeated non-compliance with meds that often leads to poor patient and graft outcome. I encourage patients to have extra meds with them if they are going out (in case they cannot get back in time). Your immune system has a very good long-term memory. ...Read more
What if you forget to take your anti rejection meds on time, but do take them a couple hours later every day?
OK: That should be fine. No doc ever expects you take the meds exactly 24 hours apart. Take them as close to that as you can. A few hours here and there won't make any real difference. ...Read more
For the first time in almost a year I forgot to take the morning dose of anti rejection meds. What should I do?
Affects your levels: If you drink grapefruit juice or eat grapefruits your Prograf levels will be higher. This may cause your surgeon to lower your dose then when you are not enjoying your grapefruit your levels will be low and your grafts will be at risk for rejection. ...Read more
Rejection risk: Hi. Rejection depends on multiple variables, and therefore is fairly unpredictable. Why has the patients skipped 3 consecutive doses? I would recommend talking with the transplant physician to see what needs to be done. Rejection is not a good thing. This patient should be more compliant with the antirejection regimen. Good luck to the patient! ...Read more
No: After spinal fusion, I would recommend you avoid nsaids or steroids. These inhibit inflammation which actually helps the fusion process to complete. Otherwise, meds as prescribed by your surgeon and resumption of other medication prescribed by other doctors is fine (even blood thinners generally ok a week or so after fusion). Rejection meds are not typically used after spine fusion. ...Read more
Needs clarification: I believe you are asking whether anti-rejection medications cause damage to the heart. Anti-rejections themselves do not cause coronary artery disease but organ transplant recipients are at increased for cardiovascular disease. Some anti-rejection meds can cause or contribute to worsening hypertension, high cholesterol, or diabetes and therefore increase the risk of heart disease and stroke. ...Read more
Yes: At the present time there is no "one time" or permanent antirejection formulation. ...Read more
Hard to say.: Immunosuppression medications are necessary to prevent the body from attacking the transplanted kidney. If the medications are stopped, the body begins to attack (reject) the organ and the kidney will eventually fail. Once this happens, dialysis will need to be started. Many factors affect the rate at which the body attacks the kidney, making an exact answer to your question difficult. ...Read more
I have had a kidney transplant 14 years ago what are the chances of getting off some anti rejection pills?
This is a discussion: You will need to have with your specialist as there are multiple variables which contribute to the necessity to remain on immunosuppressants. ...Read more
What does a steroid resistance transplant mean? Are steroids first line for anti-rejection prophylaxis?
Steroids: In the old days- which really is in the last 29 years steroids have always been first line therapy for transplants. Recently physicians have been moving to steroid- free protocols because of the side effects of steroids including diabetes, weight gain and bone disease. Steroid resistant if that is what you mean may be someone who is not a candidate for steroid therapy. ...Read more
Be careful: Unfortunately, the medicines that keep the transplanted heart working have significant side effects, like renal failure. Your dosages and levels need to be monitored very carefully by your medical team. Good luck. ...Read more
Transplant: Heart transplant management is a very specialized area and specific recommendations to a particular patient are necessary. The patient should be followed by the transplant team who knows the details of the specific patient. Making blanket recommendations in a place like this isn't a good idea ...Read more
Depends: It depends on what organ is getting transplanted and how likely the recipient is going to have a rejection episode and what other medical conditions the patient has. For example, for a kidney transplant, most patients are going to be on 2 or 3 anti-rejection meds and they will likely include tacrolimus (Prograf) and mycophenolate (CellCept (mycophenolate mofetil) or Myfortic). ...Read more
Talk to an expert: I suggest that you see your doctor or a psychologist to voice out how you really feels. There are numerous medications for depression but there are many factors that need to be considered to come up with the best medication for you, such as medical history, other meds taken, etc. ...Read more
Is it true that there are new techniques to remove antigens of donated organs to avoid rejection instead of using immunosuppressive drugs?
Not aware of any: Monoclonal antibody therapy, which blocks immune responses of key white cells (T-cell lymphocytes) is relatively new, but I am unaware of novel techniques to remove antigens from donor organs. You may want to discuss this with a large medical center transplant program if you are interested in new therapies or even in participating in a research study. ...Read more
I saw on CNN a lady who received an organ transplant but it was altered before transplanting to avoid rejection, no drugs needed. How's that possible?
Trsplt- No immunosup:
Please see the references below. Some protocols are developing to wean people off immunosupression which was unheard of before, I ma not sure if this is what you are referring to:
http://www. Aafp. Org/afp/2008/0101/p65.html
http://www. Nejm. Org/doi/full/10.1056/NEJMoa071074
Proc Natl Acad Sci U S A. 2013 Nov 19;110 (47):19054-8. doi: 10.1073/pnas.1317561110. Epub 2013 Oct 28 ...Read more
Transplant: Not sure what the question is. Best to talk to a surgeon for input. ...Read more
Not really: There is intense ongoing experimentation in this process called tolerance-universal acceptance of foreign tissue. Current approaches involve extensive manipulation of the immune system with drugs, radiation, antibodies, etc. That are hardly "natural." tolerance is the holy grail of organ transplantation. Not there yet. Only natural way would be with identical (same placenta) twins. ...Read more
Tell someone: Find someone you trust and say something. Keeping it inside does nothing. Depending on the context, find out what resources you have at your disposal to stop the bullying. DO NOT TAKE THE LAW INTO YOUR OWN HANDS. Believe it or not, most bullies are about as insecure and full of self loathing as you say you are, however, it manifests itself as them taking out insecurity and rage on safe targets. ...Read more