Doctor insights on:
Anti Migrane Agent Brain And Nerve Agent
The brain and spinal cord communicates with what is occurring in the internal organs and limbs by nerve fibers where are like electrical wires with insulation (myelin) and the "copper" (axon). Within brain and spinal cord these nerves connect to other nerves via synapses on both axons and dendrites. A nerve can carry information regarding sensations, and ...Read more
Clonidine, as a second line agent, directly reduces the hormones epinephrine and cortisol in the brain making it particularly useful for hypertension?
Less Norepinephrine: There have been two mechanisms proposed for the blood pressure lowering effect of Clonidine in the brain: stimulation of alpha-2 receptors reduce release of norepinephrine from the brain with resultant peripheral vascular dilation due to reduced sympathetic tone. The second is reduced sympathetic tone due to stimulation of the imidazoline receptors in the brain. BP and heart rate are reduced. ...Read more
How do TCAs actually work to control
non-migraine headaches? SSRIs aren't common for this, so is it the norepinephrine that is the agent helping?
Great question: Great question! Norepinephrine is definitely involved in the interpretation of pain signals in various areas of the brain. However, serotonin definitely has a role to play (eg, the triptan drugs for migraine work on a specific subtype of serotonin). So, in theory, it's thought that these components together synergistically act to alleviate headache. Hope that helps! ...Read more
Is there a connection between migranes and tumors? Are migrain headaches a symptom of a brain tumor?
A head pain which is usually recurrent, and often in variable locations and severity, associated with few or all the following symptoms; fear of light, fear of sound, nausea, vomiting, bright or dark spots floating in front of eyes, tingling and numbness of one side of face or body. All ...Read more
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