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Doctor insights on: Anti La Ssb Antibody Test

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I have a positive Ana test plus a positive SSB antibody. Also a high gran% and low lymph%. Lots of fatigue and joint pain. Can you diagnose?

I have a positive Ana test plus a positive SSB antibody. Also a high gran% and low lymph%. Lots of fatigue and joint pain. Can you diagnose?

Nonspecific: The diagnosis is that there are positive antibodies. This is not a useful diagnosis. Fatigue, joint pain and some white blood cell changes are not specific for a disease and could occur in the absence of any autoimmune disease. See your doctor and explore any other symptoms that are of concern. ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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My SED rate was 23 and most recent 31. I also have a positive SSB antibody. I was deployed to SW Asia approx 2 years ago and became very ill. ?

My SED rate was 23 and most recent 31. I also have a positive SSB antibody. I was deployed to SW Asia approx 2 years ago and became very ill. ?

Stop worrying: The sed rate is not helpful in most situations and I consider this normal. Many people have a positive anti-La/SSB. Please continue the workup if you are symptomatic. If you are not, these labs do not indicate ill-health. THank you for your service. ...Read more

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What's the difference between the sjorgren ssa / ssb antibodies? Is a level of 2.7 for the ssb antibody high? Normal is 0-0.9. Also ANA pos/ ds DNA 6.

Autoantibodies : Directed against ro/ssa and la/ssb auto antigens were originally identified in patients with sjogren's and lupus. But can be present in others autoimmune diseases. Ro/ssa and la/ssb are different intracellular autoantigens from extractable nuclear antigens. Which are soluble cytoplasmic and nuclear components. You have an autoimmune disease. More clinical info needed for diagnosis. Rheumatologist. ...Read more

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I have severe pain in my finger and toe joints, with no deformities, no injury. Seen a Rheumy, positive anti-la/Ssb, neg other tests. What could it be?

Discuss results: Full discussion of test results is a major part of the Dr's work. You need to schedule this followup and ask for a written explanation to take away so you won't feel like you need to memorize it. The complex terms confuse most folk so feel free to ask for clarity. It may help explain the pain - ask about Tx suggestions! ...Read more

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Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?

Blood tests showed high  antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere.  Is this likely lupus or a different automimmune?

Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read more

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What is the ssa/Ssb blot test antibody blood test?

What is the ssa/Ssb blot test antibody blood test?

A test: for a certain autoimmune condition. it's important to understand that these blood tests need to be interpreted carefully in the context of your symptoms and exam findings. a positive test doesn't necessarily mean you have the condition. ...Read more

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Is it normal to have pos ssb antibodies but neg ssa antibodies. The tests have been run 3 times. Someone said if that happens the ssb is a false pos?

Why do you ask?: Ssb/la is seldom positive of ssa/ro is not. However, both are merely adjuncts in considering whether someone has sjogren's (which i take it is what is at question in your case). Rather than repeat a lab that won't be the basis for a clinical decision in any case, perhaps it's time for a minor salivary gland biopsy. ...Read more

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Is a antibody nuclear test 1:320 normal?

Depends why elevated: This depends on why you have an elevated ANA. It can be there for lots of reasons. Classically we use this to diagnose systemic lupus erythematosus but most people with a positive ANA do not have systemic lupus erythematosus. As a rheumatologist we are asked to see a lot of people with a positive ANA Most of the time we find some other cause. Yours is high but it may not be high for any bad reason ...Read more

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How's a poliovirus antibody level test performed?

How's a poliovirus antibody level test performed?

Neutralization assay: Poliovirus antibodies are tested via neutralization assay for polio type 1, polio type 2, and polio type 3 separately. Protection to one type of polio does not protect you from the others. One needs to have protective titers to all three types to be "immune". ...Read more