Doctor insights on:
Anti Histone Antibody
Do anti-histone antibodies appear exclusively in drug-induced lupus or can they appear in SLE & other disorders as well?
Can lisinopril cause DISLE lupus? Have anti histone antibodies 1.4 and suffered AKI. Symptoms improved after disc lisinopril and with low dose pred.
Blood work results: "elevated rheumatoid factor & ccp c/w ra; elevated jo 1 (34h) & anti histone (1.2h) antibodies, mng" what should this mean to me?
Fertility specialist: Immunological evaluation for infertility is nonstandard but done by some fertility specialist. Most specialist do not do these test as standard testing as the results may or may not be reliable. Each positive case must be analyzed individually. Schedule follow up with the ordering physician to determine the next steps in your treatment and evaluation. ...Read more
I have positive ana, positive anti-centromere & anti-histone ab igg. R hip, b shoulder pain. Rash, sleep disturbance, sob. What should I do next?
See a rheumatologist: Have a rheumatologist evaluate the issues, . ...Read more
???: I am not sure about a correlation with blood worm and this antibody? Anti-histone antibodies are autoantibodies that are found in 50%-70% of patients with systemic lupus erythematosus (sle), but I am unawre of a correlation with blood worms? Posibly a pathologist may know of a correlation. ...Read more
Used for diagnosis: of mixed connective tissue disease (generally scleroderma with lupus overlap and muscle inflammation) for which it is fairly specific (accurate). The action of the antibody is not well characterized and probably less important than its use for diagnostic purpose (we know it binds to a protein for RNA building). In patients with anti-centromere Ab+ scleroderma, it portends kidney complications. ...Read more
A warrior increase: Think of an antibody as a soldier to help you beat the enemy (infection) if you have increasing antibodies you have more warriors. The problem here is if the warriors decide to fight against your own body rather than infection. You then have an auto-immune disease like rheumatoid arthritis. ...Read more
From immune B cells: Antibodies, also called immunoglobulins or gamma-globulins, are made in a type of white blood cell called B-cells. They are in the blood stream, lymph nodes and in the bone marrow. We have 5 different types of antibodies: IgM (first responder), IgG (good long term immunity), IgA (in the mucous lining-tears, saliva, respiratory tract and intestinal tract), IgE (allergic antibody) and IgD (unknown) ...Read more
Meds or diseases: There are many reasons. Immune suppressant medications (e.g. steroids, azathioprine, mycophenolate), chemotherapy, certain seizure meds can all cause low antibody levels. Also, immune deficiencies like CVID lead to low levels. Certain infections like HIV can cause it, too. Excessive loss of protein from chronic diarrhea can cause it. Talk with an immunologist if you have more questions. ...Read more
A test found that i don't have brusselosis , but I do have brusselosis antibodies , should I be alarmed ? What's the risk? What should I do?
Genetics: You're talking about blood group antigens; sugars on the outside of the red blood cells unique to those with certain blood types. Those who have sugars "A" and "B" should not develop antibodies to these sugars, or else such antibodies would "attack" their own red blood cells (triggering lysis). ...Read more
TSi antibody: You probably mean TSH and a TSH of 1.9 would be normal. ...Read more
No.: Antibodies do not sensitize splenocytes.Get a more detailed answer ›
Antibody clonality: Each antibody molecule recognizes a specific target. A collection of identical antibodies that all recognize the exact same target is monoclonal. A collection of antibodies that each recognize different targets is polyclonal. For example, if you have a polyclonal antibody against bacteria, all the antibodies attach to the bacteria but at different locations on it. ...Read more
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