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Doctor insights on: Anti Gad Antibodies

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Anti gad 65 is >1:2400 and says positive. In footnotes, it mentions paraneoplastic disorder. What are best next steps?

Anti gad 65 is >1:2400 and says positive. In footnotes, it mentions paraneoplastic disorder.  What are best next steps?

Ordering physician?: Ask the ordering physician. Depends why the test was ordered to begin with. Paraneoplastic syndromes are caused by a neoplastic process; it may be a concern if one has diagnosis of cancer. Anti-gad may be seen in association with paraneoplastic syndromes involving the nervous system. Note that the majority of patients with antibodies to gad do not have cancer. Discuss with ordering physician. ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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Which paraneoplastic autoantibodies are commonly seen in conjunction with anti-gad autoantibodies?

Nothing specific: The anti gad antibodies can be seen in stiff person syndrome, rasmussen encephalistis as well as in many patient is type 1 diabetes. Rarely, stiffman person syndrome can be found in patients with breast cancer and hodgkin's lymphoma. But your symptoms are not consistent with sps. I will not rely heavily on the antobody test alone. Go to see neurologist. Check your vit level, etc. ...Read more

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Can high gad-65 autoantibodies cause glutamate metabolism disorder (gmd)? What tests confirm gmd? My plasma ammonia is normal & anti-gad ab's high

Can high gad-65 autoantibodies cause glutamate metabolism disorder (gmd)? What tests confirm gmd? My plasma ammonia is normal & anti-gad ab's high

Can cause diabetes.: It seems these autoabs can cause stiff man's syndrome, a neurological disorder with impaired motor function and muscle stiffness and spasm. There is also a great deal of glutamic acid decarboxylase in the pancreas and so these antibodies act here and produce diabetes mellitus in the patient. This is likely the metabolic disorder involved. So titers of this ab, glucose, and neural tests help. ...Read more

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My gad-65 antibody level is >1:4800 rather than the u/ml measurement i see quoted online. How do I convert this number and what does it mean?

Hard to convert: The >1:4800 means they can dilute the serum from your blood more 4800 times and still detect the antibody in their test. Because of differences in how each lab performs the dilutions, runs the tests, and defines a "unit per ml", there isn't a good way to directly convert the two. However, the >1:4800 describes a very large amount of the antibody in your system. See your doctor for more info. ...Read more

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High levels of gad-65 antibodies are seen in "chronic psychotic disorders", according to pubmed journals..Explains my rage. How do u treat gad ab's?

Antibodies not prob: The antibodies are not the problem. Psychosis and rage are serious symptoms and should be addressed by a psychiatrist . Most likely medication with some type of therapy will be utilized. Sometimes a stay in the hospital is a a safe thing to do. ...Read more

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Can gad antibodies cause stiff joints?

Can gad antibodies cause stiff joints?

Possibly: Anti-gad antibodies have some role in stiff man syndrome, but not yet well understood. Anti-gad is more often associated with type 1 diabetes. ...Read more

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My gad-65 antibody level is 3.4 u/ml. Is this considered low or high? Could it be related to something other than type 1 diabetes?

My gad-65 antibody level is 3.4 u/ml.  Is this considered low or high?  Could it be related to something other than type 1 diabetes?

GAD-65: This is considered elevated and is used in diabetes type 1 evaluation. It has also been employed in evaluating and confirming a diagnosis of stiff-man syndrome, autoimmune encephalitis, cerebellitis, brain stem encephalitis, myelitis. ...Read more

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When patient has autoimmune flares that cause weeks of glucose intolerance and diabetes-type symptoms that resolve, would it be useful to test for antibodies to gad, insulin or islet cells?

Possibly: Autoimmune diseases tend to occur together, so checking for antibodies for type 1 dm can be helpful to assess for that diagnosis. Glucose tolerance should not fluctuate with a flare in gad/insulin/islet abs. It it more likely to be from treatment of the autoimmune flare (steroids) or stress from the flare. ...Read more

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Can lupus directly impact the brain? Myoclonic seizures, major depression, GAD, major mood swings. No official diagnosis, but positive for antibodies.

Can lupus directly impact the brain? Myoclonic seizures, major depression, GAD, major mood swings. No official diagnosis, but positive for antibodies.

A few comments: Yes, lupus cerebritis can occur. Spinal fluid measure of P-ribosomal protein might help. Your myoclonic seizures could be Juvenile Myoclonic Epilepsy, and could benefit from Depakote or Keppra (levetiracetam). Your emotional state could be assessed by psychiatry. Recommend you see a neurologist, and have all of this looked at thoroughly. ...Read more

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Dr. Heidi Fowler
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