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Doctor insights on: Anti Dsdna Antibodies

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Crp .1 mg/l. Ra/anti-dsdna antibs/ana all negative. Why might hematology report indicate "suggested reactive or inflammatory process"? Also noted subset of reactive lymphocytes, occasionally atypical.

Crp .1 mg/l. Ra/anti-dsdna antibs/ana all negative. Why might hematology report indicate "suggested reactive or inflammatory process"? Also noted subset of reactive lymphocytes, occasionally atypical.

See below : Reactive (atypical) lymphocytes are usually due to viral illness or stressor on the body. It could be due to a medicine reaction or autoimmune disorder as well. Your CRP level of 0.1 is very low which is good. And your ra/anti ds dna are negative. So overall they didn't find anything abnormal and they called it possibly due to reactive process. ...Read more

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Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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What do you recommend if I have elevated ANA and anti dsdna antibody?

What do you recommend if I have elevated ANA and anti dsdna antibody?

See details: I would recommend you consult with a rheumatologist to determine if these values have any clinical significance. ...Read more

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Does it mean I have lupus if my ANA came back at 1:320 when anti-dsdna antibodies and sedimentation are normal?

Does it mean I have lupus if my ANA came back at 1:320 when anti-dsdna antibodies and sedimentation are normal?

Not necessarily: The ANA is non-specific and can be positive in other diseases and also in normal people. It has to be evaluated in the context of the physical symptoms. If you have concerns, see a rheumatologist. ...Read more

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Ana went from 1:80 spck to negative, VHS went from 50 to 10mm in 1week. Negative anti-dsDNA, Antibodies to Ro/SS-A and La/SS-B, RNP and SM. Lupus?

Ana went from 1:80 spck to negative, VHS went from 50 to 10mm in 1week. Negative anti-dsDNA, Antibodies to Ro/SS-A and La/SS-B,  RNP and SM. Lupus?

Probably not : A low level ANA can be seen as a auto immune phenomenon of Hashimoto's thyroiditis (which I see you have). The specific lupus tests are (-). Joint pain without joint swelling is not a reliable diagnostic finding for lupus. ...Read more

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Negative ANA blood test but positive anti-dsDNA antibodies. Do I have lupus? What causes this? Very symptomatic.

Negative ANA blood test but positive anti-dsDNA antibodies. Do I have lupus? What causes this? Very symptomatic.

Rheumatologist: This test alone is insufficient to diagnose lupus. It has to be supplemented with appropriate symptoms and physical findings. A rheumatologist is best qualified to evaluate, advise, and treat you, if needed. ...Read more

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Negative ANA, negative Anti-DSDNA, negative Sjögren antibodies, normal ESR, normal C-RP, normal CBC. Does this rule out lupus or Sjögren syndrome?

Negative ANA, negative Anti-DSDNA, negative Sjögren antibodies, normal ESR, normal C-RP, normal CBC. Does this rule out lupus or Sjögren syndrome?

Yes, I would say : Your chance of of having lupus or Sjogren is less than 1 to 2% with those negative serology. But I would say majority (if not all) of rheumatologist would likely advise you to look for other diagnosis unless you have tissue biopsy to suggest otherwise. ...Read more

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At mayo clinic i tested positive for anti dsdna. Latest test says negative (l) dsdna. If positive are you always positive?

At mayo clinic i tested positive for anti dsdna. Latest test says negative (l) dsdna. If positive are you always positive?

Depends on lab: A lot of this depends on what your problems are. Specifically however laboratory studies can sometimes cause conflict. It depends on whether the test was done the correct way, and lab tests can vary even day today. Some labs do a better job than others. This may also depend on the technique of the type of dna test that was done. Your physician can help clarify this. ...Read more

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I had some reumatology tests, and the anti-dsdna value is 43.2 u/ml. Should i be worried or am suspect of les? Thank you very much

I had some reumatology tests, and the anti-dsdna value is 43.2 u/ml. Should i be worried or am suspect of les? Thank you very much

Possibly: The dna positivity is suggestive of lupus if the clinical picture is consistent with lupus. The dna may occasionally be positive in other disorders. ...Read more

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Normal lab test for anti dsdna is < 1:20 . Is 1:20 considered negative or positive or borderline ? Thank you

Basically negative: With that number it is basically negative, but doctors do not treat numbers we treat patients so that in itself does not rule out lupus. ...Read more

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