Doctor insights on:
Anti Coagulation Drug Medication
It's not: Aspirin, although, used for anticoagulation, is drastically different from warfarin. It acts upon platelets preventing their aggregation, whereas warfarin acts upon clotting factors (proteins) in the liver, therefore being much stronger in its ability to thin blood. For DVT prophylaxis warfarin is indicated and Aspirin is not. ...Read more
I presume you are a male on testosterone replacement. There are risks and benefits and lab studies should be done every three months.
Testosterone by injection is far less expensive than other options for testosterone but that might be the treatment of your doctor's choice now that you are on anticoagulation therapy. ...Read more
An 89 yr male had heart attack 1mth after stroke he is in Afib taking clopidogrel aspirin. Hospital doctor wants to give a third anti-Coagulation, Risk?
Depends on: Circumstances. In a normal person, usual drugs and foods do not affect pt measurably. In patients on warfarin, foods both prolong pt, e.g., grapefruit, or shorten it, e.g., green leafy vegetables. Many drugs affect pt, e.g., birth control pills, isoniazid, anti-fungals, antibiotics, and many other drugs metabolized through cytochrome p450 system, and barbiturates and alcohol. ...Read more
Which one better between pradaxa abd Plasmin Capsule (anti-coagulant drugs from china ; Lubrokinase)?
Pradaxa: We are in favour of pradaxa.Get a more detailed answer ›
I'm in AF also CAD. Now taking pradaxa, may be change into plasmin (anti-coagulant drugs from china, Lumbrokinase)?
Pradaxa vs lumbrokin: I would NOT recommend this - while Pradaxa is costly - it comes with the approval of the FDA along with extensive testing for efficacy and safety. From my research Lumbrokinase is derived from earthworms and is still considered investigational. I would be leery of any medications obtained from off shore (NO I do NO work for big Pharma) their safety and efficacy are unproven. ...Read more
Yes: Clotting = coagulation.Get a more detailed answer ›
What blood tests would I need to determine if my blood coagulation is normal? Or if it is thick from hereditary issues or medical issues.
Many tests: I would start with PTT, PT/INR and plattelets. For the hereditary clotting disorders there are many tests and unless you have had a clot they are probably not necessary. If people in your family have had blood clots then find out what disorder they have and you can be tested for that. Testing for all possible clotting disorders is extremely expensive. ...Read more
Vitamin k is a necessary participant in synthesis of several proteins that mediate both coagulation and anticoagulation. Vitamin k deficiency is manifest as a tendency to bleed excessively. Indeed, many commercially-available rodent poisons are compounds that interfere with vitamin k and kill by inducing lethal hemorrhage.
Lack of vitamin c, the basic defect of scurvy, does not affect coagulation. ...Read more
Same thing: Clotting and coagulation are used as synonims. A hematologist could beg to differ, but otherwise used as absolute synonims. ...Read more
Factors I to XIII:
There are 12 coagulation factors, named by numbers, except that there is no factor VI.
You may consult this site for more info:
http://www. Essentialhaematology6.com/tables/chapter24.pdf ...Read more
Yes: PRV is hypercoaguable conditionGet a more detailed answer ›
Better test avail.: It is not used these days because the APTT (activated partial thromboplatiin time) is more accurate to measure coagulation problems in the intrinsic pathway. ...Read more
Yes: A coagulation defect changed world history. Queen Victoria passed it to her daughter Alice, who in turn passed it to Alexandra, wife of Czar Nicholas, whose son Alexii was a bleeder--and they fell under the influence of Rasputin, ignoring the affairs of state. Carrier women are not affected; their normal factor VIII gene on their other X-chromosome makes up for the abnormal gene. ...Read more
Coag testing: I would look this up in your textbook. ...Read more
Risk of bleeding: Bleeding time is no longer used as it is a poor predictor of bleeding risk, clotting time is too crude a test, prothrombin time tests the status of one branch of the coagulation pathway. Usually pt and PTT and platelet count are used as screening tests to assess risk of abnormal bleeding. ...Read more
ICU?: Most patients with dict are usually very sick and in the intensive care unit. Intensivists/critical care doctors would be main person. Since this is a blood disorder, often times hematologists are involved as well. ...Read more
Consumption: It is a consumptive clotting problem with many causes where your blood clotting factors form clots apothem break them down constantly causing your body to loose its ability to form clots where needed. ...Read more
Yes: Alteration in blood flow is one of the causes of clot formation. ...Read more
Take her to ER: If your wife has disseminate intravascular coagulation you ought to get her to an er right away, better yet call 911. ...Read more
DIC: This is a condition where the body's normal blood clotting and thinning mechanisms are disrupted and small blood clots form in the small vessels. These numerous clots cause consumption of the body's clotting factors and then bleeding occurs. Infection is the most common stimulus for this process. ...Read more
Clotting & bleeding: Dic causes two opposite problems: blood clots when it shouldn't, then abnormal bleeding occurs. The blood has enzymes to cause clotting--if you have a small cut, the blood clots naturally to help stop bleeding. In dic, abnormal clotting happens; clots form in the small blood vessels all over the body. When all the clotting enzymes get used up, it's a setup for bleeding. ...Read more