Top
10
Doctor insights on: Ankylosing Spondylitis Hla B27

Share
1

1
If I have hla-b27 gene and sacroilitis will i develop ankylosing spondylitis?

If I have hla-b27 gene and sacroilitis will i develop ankylosing spondylitis?

If you are B27+: If b27 positive with clinical and radiographic sacroiilitis, you have as. But most patients do not ankylose. Therefore the "name" is somewhat archaic. But treating for pain is inappropriate. Other drugs are needed to suppress inflammation, both for preventing other rheumatic problems, and heart disease and stroke! ...Read more

See 1 more doctor answer
Dr. Pierre Moeser
162 doctors shared insights

Ankylosing Spondylitis (Definition)

-defect that effects the spine, causing ligaments and other elements of the spine to calcify, & making it essentially fused in severe cases. As the spine calcification takes place, it is painful, & flexion is more comfy. So accentuated kyphosis CS&TS. Essentially ending fixed downward gaze. It effects hips, & has pulmry compromise 2nd 2 deformity. Indomethacin is manic early for slwng ...Read more


2

2
If positive for the hla b27 gene and 2cases of iritis, does this mean I have ankylosing spondylitis for sure? R these 2 factors enough for a diagnosis?

No: Hla b27 increases the risk for uveitis. Ankylosing spondylitis is associated with this but the diagnosis is made by physical exam and positive spine and hip x-rays. I have lots of patients with uveitis and hla b27 without other disease. ...Read more

See 2 more doctor answers
3

3
Can Ankylosing Spondylitis effect the thoracic spine more so than the sacral? If so what imaging would be best for diagnosis? I'm HLA-B27 pos - NO Dx

Can Ankylosing Spondylitis effect the thoracic spine more so than the sacral? If so what imaging would be best for diagnosis? I'm HLA-B27 pos - NO Dx

Yes. The disease is-: -unpredictable. Early sign is decreased chest expansion, then it can effect SI joints, entire spine but more so cervical & thoracic. Also there is about 10% false positive tests using HKA-B27. So look @ chest expansion as the earliest sign of true AS. ...Read more

4

4
I recently developed a series of symptoms: lower back pain, eye inflammation, skin hives, etc. Test HLA-B27 postive. Do I have Ankylosing Spondylitis?

The signs and: symptoms you describe would lead one to place Ankylosing Spondylitis at the top of the differential diagnosis list. Be sure to follow with your Ophthalmologist for your iritis and with your Rheumatologist for the evaluation of the HLA-B27 results. There are other disease that can have the same constellation you are describing and rarely two processes can be occurring simultaneously. ...Read more

5

5
Have backpain. Probably sacroilitis from the location of the pain. Need to test for ankylosing spondylitis? Hla gene?

Have backpain. Probably sacroilitis from the location of the pain. Need to test for ankylosing spondylitis? Hla gene?

Maybe: Back pain is a very common symptom. It does not always mean a spinal disease and can be as simple as overuse. It does not always require testing to determine the cause. Pain from a. S. Is typically worse at rest and improves with activity. See your doctor for a definite answer. ...Read more

See 1 more doctor answer
6

6
I am hla b 27 positive n suffering from ankylosing spondylitis, done with bilateral hip replacement, n now neck fusion of all facet joints, taken remicad?

I am hla b 27 positive n suffering from ankylosing spondylitis, done with bilateral hip replacement, n now neck fusion of all facet joints, taken remicad?

For AS patients: An auto fusion of the spine is not uncommon and one has to exercise and maintain as best posture possible while this occurs. Weight control and not smoking are also important as well as controlling symptoms with medication as you are currently doing. ...Read more

8

8
Can ankylosing spondylitis effect you much?

Maybe: It can cause pain, lead to fixed deformities of the spine and place you at higher risk for a spinal fracture in a fall or accident scenario due to loss of flexibility. You should see a rheumatologist for treatment. ...Read more

See 1 more doctor answer
9

9
How do you diagnose ankylosing spondylitis ?

Rheumatologist : You should be evaluated by a rheumatologist and have a complete physical examination including radiographs of your spine and a series of blood test including hla b27. ...Read more

See 1 more doctor answer
10

10
Is it okay to drive with ankylosing spondylitis?

Sure: It generally fine. However, if your cervical spine movement is severely limited be sure to make use of your outside mirrors at every opportunity and consider buying cars in the future with a backup camera and self-parking capability. ...Read more

Dr. Corey Clay
59 doctors shared insights

Hla B27 (Definition)

Hla = human leukocyte antigen. Important in recognition of self and not self. Different proteins (antigens) for different people. B is one of the loci, and hlab27 has been associated with predisposition to immunologic rheumatologic ...Read more


Dr. Michael Nelson
219 doctors shared insights

Spondylitis (Definition)

An inflammatory condition of the spine such as ankylosing spondylitis. Spondy = spine ...Read more