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Doctor insights on: Anion Gap Correction For Albumin

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I am on methotrexate. Labs say that albumin/globulin and anion gap are low with bilirubin in urine. Should I be worried?

I am on methotrexate. Labs say that albumin/globulin and anion gap are low with bilirubin in urine. Should I be worried?

Yes: Your physician knows how to handle this. Managing patients on Methotrexate is a matter of weighing the benefits in treating the illness against the predictable danger to the liver. The bilirubinuria is more specific for a liver problem. Trust your physician on this; I trust you stay physically fit and do not use alcohol.

Dr. Raj Singh
266 Doctors shared insights

Albumin (Definition)

Albumins are proteins which dissolve in water and are not covered with chains of sugars. The most common is serum albumin. These molecules transport other molecules which don't dissolve in water very well. But its main function is to regulate the amount of water in the blood. Another type of Albumin is the ...Read more


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What could cause a neg anion gap on blood test w low albumin and low tot protein? Seen it on blood work over the past year. Have ruq pain no diagnosis

What could cause a neg anion gap on blood test w low albumin and low tot protein? Seen it on blood work over the past year. Have ruq pain no diagnosis

Reason for concern: You have low Albumin and protein, this is not a matter that should go unexplained. You are either not producing enough Albumin or you are loosing proteins too fast. You should have a diagnosis, you doctor should figure it out.

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Blood work results, chloride was low at 98 mmol, anion gap was high at 17.4, glucose was high at 108 mg/dl, A1c was 6.2, albumin/globulin ratio 2.0?

Blood work results, chloride was low at 98 mmol, anion gap was high at 17.4, glucose was high at 108 mg/dl, A1c was 6.2, albumin/globulin ratio 2.0?

Prediabetes: Hi. That A1c is above normal, & if that glucose is FASTING, it is too (it's not abnormal if it's not fasting). They demonstrate "prediabetes", the abnormal state between normal & diabetes. What was your bicarb/total CO2? Unless it was low, anion gap (a calculated value) doesn't mean anything; it's useful in states of ketoacidosis, lactic acidosis, etc). A:G ratio is fine too. Eat healthy, exercise

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Can you define what the anion gap is?

Can you define what the anion gap is?

Anion gap: Hi. The most common way to measure anion gap (AG) is to subtract the serum chloride concentration and the serum CO2 concentration from the serum sodium concentration. AG = Na - (Cl + total CO2). The AG is due to unmeasured anions in blood. Depending on lab, normal AG is up to about 12 or 14. In acidotic states such as diabetic ketoacidosis, lactic acidosis, sepsis, etc), AG is increased.

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My anion gap came back at 5 should I be worrid?

Depends: Interpreting the anion gap really depends on clinical context. An anion gap of 5 could be normal in some people, but could also signify something like low albumin.

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Should a person worry if anion gap is low at 3.9?

No: This means nothing. Reference ranges are arbitrarily set so that 5% or so of healthy folks fall outside.

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What is a high anion gap reading. When should I be concerned.?

What is a high anion gap reading. When should I be concerned.?

16+: Each lab has its own range of normals. Ag was a concept designed to help doctors figure out the source of acidosis, just a tool not a measure of how sick you are. If you are significantly acidotic the ag is useful. If you are not acidotic it is just a number spit out by the lab. A low ag may be seen with multiple myeloma.

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What does it mean if your anion gap is low and your sodium is normal in the middle of the range? Should I be concerned?

What does it mean if your anion gap is low and your sodium is normal in the middle of the range? Should I be concerned?

No need for worry: The anion gap is calculated by subtracting serum concentrations of chloride and bicarbonate (sodium bicarbonate) ions from sodium. If it falls below 3 meq/l, it is defined as low. The most common cause is laboratory error. Another less common explanation includes a low serum Albumin concentration.

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Anion gap 20, glucose101. Not diagnosed with diabetes? Is that what this usually is, could it be something else, and do I need to worry?

Anion gap 20, glucose101. Not diagnosed with diabetes? Is that what this usually is, could it be something else, and do I need to worry?

High anion gap: A high anion gap (ag) can be caused by: milk-alkali syndrome uremia diabetic ketoacidosis propylene glycol Isoniazid intoxication lactic acidosis ethanol ethylene glycol rhabdomyalysis and Aspirin intoxication. Your glucose of 101 is not elevated. It is always best to speak to the doctor (d) who ordered the glucose and ag to see what they mean in your case.

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What does high mpv and high anion gap mean?

What does high mpv and high anion gap mean?

Nothing: Labs mean nothing in isolation. High MPV usually means nothing in any case unless the person is otherwise clearly sick. I raise my anion gap every time I exercise. Reference ranges are set so that several percent of healthy folks fall outside on either end. If your phyiscian isn't worried, stop worrying yourself. Best wishes.

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78.8 mcv, 26 mch, 15.2 rdw, 0.6 creatinine, 5 anion gap. Could you please interpret these labs for me? Thank you!

78.8 mcv, 26 mch, 15.2 rdw, 0.6 creatinine, 5 anion gap. Could you please interpret these labs for me? Thank you!

Looks like low blood: You have a low MCV and mchc. Your RDW is high and your anion gap and creatinine are normal. It looks like with your high RDW and other low blood results that you've got some anemic process going on. The high RDW could mean that there is a destructive process to your red cells as this shows a great difference in the size of your red cells. It would help to see your dr. And get a blood smear.

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Is an anion gap of 14 anything to worry about?

Is an anion gap of 14 anything to worry about?

NotIfYouFeelWell: It's a little high but the usual causes for a delta gap of 1-2 (which is where your number falls) range is usually a lactic acidosis and in some circumstances diabetic acidosis. Do you exercise? Do you drink plenty of water? To really give an accurate interpretation, more information is needed about your medical history, medications you take, and symptoms.

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What does it mean when your anion gap is high?

What does it mean when your anion gap is high?

Acidosis: It means there is too much acid in your blood at the expense of more negatively charged substances (anions) being consumed (bicarbonate (sodium bicarbonate) (sodium bicarbonate (sodium bicarbonate)) and chloride) than positively charged substances (unmeasured cations h+), which consume the bicarbonate (sodium bicarbonate).

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Hello. I was told I have an anion gap of 18 which is above normal. Is this a big concern?

How do you FEEL?: If you feel okay, I'd ignore it. Reference ranges are set so that a few percent of healthies fall outside on either end, as you have.

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What causes a lower than normal anion gap? Mine has fluctuated from normal to one point below normal.

What causes a lower than normal anion gap? Mine has fluctuated from normal to one point below normal.

Not material: One point below normal is not clinically meaningful. If you do not have any symptoms, do not worry about a lab value. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex, if you have sex.

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Sent a "free" message about low anion gap at least 2 days ago - how long before a response and how do I get it? Via direct email or by logging in some

A "low": Anion gap means nothing, as the whole point of the calculation is to estimate unmeasured anions.

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Is anion gap test from blood or urine just curious?

Is anion gap test from blood or urine just curious?

Blood: It's of zero value in urine, which is loaded with sulfates and phosphates and urates and whatever else.

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Is normochloremic normokalemic RTA possible? Anion gap usually normal. Sodium usually on low end of normal.

Is normochloremic normokalemic RTA possible? Anion gap usually normal. Sodium usually on low end of normal.

Unlikely to be RTA: Further evaluation with comprehensive history, physical exam and repeated labs are needed to determine the true significance of abnormal blood work results. Recommend discussing your concerns with a PCP and/or kidney specialist.