Doctor insights on:
Angiotensin Ii Blocker Medication
Hypertension: Angiorensin ii is a potent vasoconstrictor and proinflammatory chemical that has effects on vascular endothelium that contribute to atherosclerosis and hypertension. In the heart it increases hypertrophy and increases arrhythmic potential. It stimulates aldosterone. It is formed through a chemical conversion of angiotensin I to angiotensin ii mediated by sympathetic activation of ace. ...Read more
AII vs aldo and salt:
Aldo causes more Na retention and water follows salt.
But depends on circumstances. AII is major drive to aldo production so if AII high get same effect if you don't die form the severe HTN from excess AII.
Both can be counteracted if you eat less salt. I am a specialist in the renin angiotensin aldosterone system and happy to consult with you. ...Read more
Test: You can measure angiotensin two levels. I would talk to your cardiologist or renal specialist about the need to do this. ...Read more
Angiotensin II: Angiotensin ii stimulates the adrenal cortex to produce aldosterone which regulates salt and water reabsorption in the kidney. It is a vasoconstrictor and has effects to drive up BP through both these mechanisms. It potentates sympathetic neural output at the pregnant livonia level. ...Read more
If someone was to have low angiotensin II and low aldosterone would you expect to see a lower renin also?
Renin levels: If one has a low aldosterone and angiotensin ii, one would expect a high renin level. Renin leads to angiotensin I and ii synthesis. If those levels are low and the person is ambulatory, the person's renin would be expected to be high. For a diagram of the renin-angiotensin-aldosterone system go to this link; http://www. Google. Com/search? Hl=en;site=imghp;tbm=isch;source=hp;biw=2556;bih=1234;q=renin+angiotensin+system;oq=+angiotensin+sy;gs_l=img.1.1.0j0i5l9.576.4679.0.9029.16.9.0.18.104.22.168.974.0j5j1.6.0....0...1ac.1.35.Img. 5.11.985.Luxw_l48srm#fa. ...Read more
Why does Primary hypoaldosteronism lead to increased renin and Angiotensin II, but secondary hypoaldosteroninim does not?
Renin-AT II-ALD axis: With primary (1°) hypoaldosteronism, feedback on the renin-angiotensin (AT) II-aldosterone (ALD) axis would cause the kidneys to increase renin and thereby AT II to try ^ adrenal ALD. In 2° hypoaldo, there is usually kidney damage (for example, due to diabetes) which decreases renin and hence AT II (which is produced in response to renin). This causes ALD (which depends on AT II) to v (hence 2°). ...Read more
If there is a normal level of renin, there should be a normal level of angiotensin II and aldosterone right? So low angiotensin II = low aldosterone?
Aldosterone: Not really. It depends upon sensitivity of adrenal galnds to angitensin ii. ...Read more
Is there anyway to increase angiotensin ii, my body does not produce it despite normal renin, autonomic nerve issue.
Meaningless: If your renin is normal, you don't need any higher angiotensin ii which is an intermediate step in the synthesis of renin. From you posts, it sounds like you might have hypothalamic/pituitary insufficiency - have you seen an endocrinologist? ...Read more
Very low angiotensin ii, normal ACTH, aldosterone, cortisol and renin? Why angiotensin ii very low if everything else normal? Doesn't make sense?
Data: Need more data. You should see a good endocrinologist. ...Read more
Aldosterone 161 pmol/l - renin/aldosterone ratio 5 - renin 11.4 ng/l - angiotensin II 8ng/l. I have postural orthostatic tachycarda. Why low angioten?
All connected: I am not an expert on this and you don't mention your lab standards so it is hard to say, but they are all connected to each other to regulate the volume of fluid and salt held or released by your kidney and there for your blood pressure. Too little salt then too little volume of blood and BP drops when you stand. ...Read more
Male 22 angiotensin II was 8ng/l and aldosterone 161 pmol/l I urinate a lot and have pots. Could this cause low blood volume?
Can't answer: Normal values vary from lab to lab. This question is complex and can't be answered in a vacuum. ...Read more
Why is my angiotensin II only 8 normal range 20-40ng/l? My aldosterone was 161 p/mol. I have dysautonomia and pots. I pee a lot when I drink.
Angiotensin II: A specific radioimmunoassay for angiotensin ii showed that normal concentration in arterial blood is 2·4±1·2 (s.D.) mμg./l00 ml.; venous level is consistently below this value, usually 50–75% of it. Definite rises in blood angiotensin ii were found in some patients with hypertension, both essential and secondary to renal disease. Extremely low levels observed anephric state and conn's syndrome. ...Read more
If someone had low angiotensin ii, low aldosterone and low vasopressin. Took florinef (fludrocortisone) would it retain water even though low vasopressin?
I pee a lot of what I drink low normal aldosterone low angiotensin ii. Will florinef (fludrocortisone) help me retain more and pee less?
Think about this:: If you urinate just 10 cc more than you take as food or drink per day, in 1 year, you'll be 3.6 liters drier and in 5 years, 20 liters behind! (not possible). No, your kidneys carefully balance your fluids. What low aldosterone and angiotensin control is your BP and your sodium ; potassium. Flurinef will raise your BP and help you retain sodium and excrete potassium. ...Read more
Potassium 3.4 (3.5-5.0) got dysautonomia. Low aldosterone low angiotensin ii. Need florinef (fludrocortisone) but potassium will be lower. What causing this?
Review this again:
Aldosterone deficient patients that require fluorinef are almost by definition hyperkalemic. Florinef (fludrocortisone) will make the k lower.
The condition you describe (low aldosterone, adrenal insufficiency) comes with high k, non gap acidosis and low blood pressure. The low k does not fit. Perhaps this is a form of barrter's syndrome. Please review with your physician. ...Read more
67 yrs. Angiotensin 1 converting enzyme (ace) serum 126.7, what should be done? Bad? What does this mean? Life style changes. Medication? Thank you
51 M Notes: 67 yrs angiotensin 1 converting enzyme (ace) serum 126.7, what should be done? Bad? What does this mean? Life style changes. Medication? Thank you
ANS: not enough information to help at this point. Are you 51 or 67? Need to know why it was measured, what meds, other illnesses, & what is normal in that lab. Get this information & will be happy to do 2nd opinion as I specialize in RAAS ...Read more
Major BP problems...: Angiotensin-1-converting enzyme converts angiotensi-1 to angiotensin-2, an extremely potent vasoconstrictor, leading to high bp. It is triggered by renin, produced in the kidneys due to low blood flow. The angiotensin converting enzyme inhibitors, or acei's are used to block this, but some still gets converted in the tissue, so we use angiotensin receptor blockers, or arb's. ...Read more
Losartan: Losartan is the only generic angiotensin receptor blocker available at this time. There are however several inexpensive angiotensin converting enzyme inhibitors available which generally work as well and would be a good option unless you have side effects such as cough from it. ...Read more
None: Not yet. There are none available in the USA. ...Read more
I have a slightly elevated angiotensin conv. Enzyme the cut off was 53 and I was 64. Does this mean I have sarcoidosis? And is that a fatal illness?
See below: Sarcoidosis can be such a mild disorder that no treatment is needed or can be life-threatening. Most of the time simple treatments - not steroids - will control the disease. Workup for underlying causes/mimics is essential. Ace levels are meaningful only related to clinical symptoms. Rheumatologist should provide clarification. ...Read more
peptide hormone: Produced mostly in liver, angiotensin 1 is formed after renin cleaves angiotesinogen. Renin is produced in kidneys. Angiotensin 2 is formed after ace cleaves part of it off. This than causes increased vasomotor tone as well as salt and h20 retention. This is the target for the acei drugs. ...Read more
Physiology: Angiotensin is converted from angiotensinogen and functions to help the body secrete aldosterone (which results in salt and water retention). Angiotensin I converts to angiotensin ii, and angiotensin ii has potent vasoconstrictor and proinflammatory effects on the vasculature. ...Read more
http://circ. Ahajournals. Org/content/108/3/e16.full
Names say it all: Angiotensin converting enzyme (ACE) inhibitor vs angiotensin receptor blocker (ARB). The names really say it all. Angiotensin which raises blood pressure needs to be activated to work. ACEs prevent that activation. ARBs directly block the activity of angiotensin. Both have similar effects but there is more evidence for heart protection with ACEs than ARBs but slightly more side effects with ACEs. ...Read more