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Doctor insights on: Anemia Sideroblastic Spinocerebellar Ataxia

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How are cerebellar degeneration, cerebellar ataxia and paraneoplastic cerebellar related?

How are cerebellar degeneration, cerebellar ataxia and paraneoplastic cerebellar related?

Ataxia: Cerebellar degneration means that the part of the brain that controlls coordination and balance is losing cells and likely getting smaller. Ataxia is the clumsiness, imbalance, slurred speech and/or abnormal eye movements that can accompany cerebellar degeneration. A paraneoplastic cerebellar syndrome is when the body's immune response to cancer somewhere else damages the cerebellum "by mistake". ...Read more

Dr. Chad Levitt
193 doctors shared insights

Ataxia (Definition)

Ataxia means movements without coordination. People with ataxia have incoordination because the parts of the nervous system that control movement and balance are not working properly. Ataxia can be associated with infections, injuries, or degenerative changes in the central nervous system. Ataxias may be hereditary ...Read more


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Is sickle cell anemia hereditary?

Is sickle cell anemia hereditary?

Yes.: it is an autosomal recessive disorder, meaning that both parents must be carriers of the mutation. If they are, the chance of each child being affected is 1 in 4. ...Read more

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Is autoimmune hemolytic anemia hereditary?

Is autoimmune hemolytic anemia hereditary?

No: It can be due to an underlying autoimmune disorder, such as lupus or rheumatoid arthritis. In this case, the underlying autoimmune disorder may be hereditary; but the autoimmune hemolytic anemia is not hereditary. It is simply the manifestation of the underlying disorder. There are also several causes of autoimmune hemolytic anemia that are not inherited. ...Read more

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Is megaloblastic anemia an inherited condition?

Is megaloblastic anemia an inherited condition?

Not commonly: Most cases of this condition reflect deficiencies of key vitamins (b12, folic acid) and occur due to dietary deficiencies, pregnancy, pernicious anemia, medications. Rare inherited forms can occur in which the carrier proteins for B12 may be low for example. ...Read more

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What are ataxia, cerebellar or spinocerebellar degeneration?

What are ataxia,  cerebellar or spinocerebellar degeneration?

Progressive disorder: Genetic and familial conditions can lead to a progressive degeneration of the cerebellum and brainstem structures. There are many different types. Multiple sclerosis can also cause progressive balance problems that can mimic degenerative disease. Tumors can also mimic degenerative disease. A quality MRI and good neurological evaluation is necessary. ...Read more

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What's spinocerebellar ataxia?

What's spinocerebellar ataxia?

Archaic term and : Not used in academic settings due to confused terminology. Was used to describe both hereditary and sporadic neurodegenerative ataxias, but now classify these based on genetic and molecular markers. Amongst these, friedreich's ataxia, ataxia telangiectasia, sca 1-7, mitochondrial. Ataxia is incoordination of movement due to cerebellar dysfunction. ...Read more

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Does nomochromic normocytic anemia indicate renal impairment?

Does nomochromic normocytic anemia indicate renal impairment?

Not necessarily: Normocytic normochromic anemia can be caused by acute blood loss, early iron deficiency, bone marrow supression, anemia of chronic disease, anemia of renal insufficiency, anemia caused by endocrine problem etc. ...Read more

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Describe symptoms of sickle cell anemia trait?

Describe symptoms of sickle cell anemia trait?

Usually none.: Patients with sca trait usually have no symptoms. If they are in an environment where oxygen is low, like high altitude, it is possible to have a pain crisis like sca patients get, but it is quite rare. ...Read more

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Can normochromic or normocytic anemia cause leukemia?

Can normochromic or normocytic anemia cause leukemia?

No: Anemia (normochromic/cytic or not) can be a sign of leukemia (or a variety of other cancerous or non-cancerous conditions). That is it can associated with leukemia. However, it does not cause leukemia. Correlation does not equal causation. ...Read more

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Is polychromasia typically associated with microcytic anemia (iron deficient anemia)?

Is polychromasia typically associated with microcytic  anemia (iron deficient anemia)?

Iron deficiency is: Usually hypo chromic. Polychromasia is seen in rapidly changing circumstances like hemolytic anemia. ...Read more

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How are aplastic and hemolytic anemia differentiated?

How are aplastic and hemolytic anemia differentiated?

See below: Aplastic anemia is when the bone marrow stops producing blood cells. Hemolytic anemia is when red blood cells are being destroyed outside of the bone marrow. ...Read more

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What type of genetic disorder is sickle cell anemia or trait?

Hemoglobinopathy: Patients with sickle cell anemia make an abnormal hemoglobin (hgb.). Normal HGB consists of paired protein chains (globin) and an iron containing part (heme). Patients with ssa inherit an abnormal beta-globin gene from each parent. Carriers have one normal beta-globin gene and one sickle beta globin gene. The carriers (trait) have no symptoms. ...Read more

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What can cause spinocerebellar ataxia?

What can cause spinocerebellar ataxia?

Variety of causes...: The causes of spinocerebellar ataxia span several pages, but can be categorized as: hereditary, infectious, medication-related, alcohol-related, traumatic, vitamin deficiency related, etc. The start of an evaluation for ataxia includes a detailed neurological exam by a movement disorder specialist and a brain MRI to see whether the cerebellum is indeed shrinking. ...Read more

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Is spino-cerebellar ataxia contagious?

Is spino-cerebellar ataxia contagious?

No: Spinocerebellar degenerations are genetic disorders that run in families. There is no infectious component. ...Read more

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Megaloblastic anemia can lead to some neurological disorders?

Megaloblastic anemia can lead to some neurological disorders?

Yes: Megaloblastic anemia is most commonly caused by vitamin B12 or Folic Acid deficiency. Neurologic symptoms might include weakness, numbness, difficulty walking and with balance. ...Read more

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Is malaria and sickle cell anemia related?

Is malaria and sickle cell anemia related?

Sickle cell Trait: can offer some protective value regarding severity of malarial disease. In a person who has sickle-cell trait – the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life, before the onset of clinical immunity..." ...Read more

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What is anemia megaloblastica?

Megaloblastic anemia: Megaloblastic anemia (or megaloblastic anaemia) is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis during red blood cell production.[1]The defect in red cell DNA synthesis is most often due to hypovitaminosis, specifically a deficiency of vitamin B12 and/or folic acid. ...Read more

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Dr. Hamid Sajjadi
56 doctors shared insights

Loss Of Coordination (Definition)

Loss of coordination is a symptom in which some parts of a person's body should but do not work together in a coordinated way. One example is when several muscles move in an uncoordinated manner, ...Read more


Dr. Andrew Seibert
125 doctors shared insights

Trouble Walking (Definition)

The inability to ambulate in a normal manner. This gait disturbance can be due to a host of reasons to include, but not limited to, orthopedic, ...Read more