Doctor insights on:
Anemia In Neoplastic Disease
The bad cells: In simplest terms, the sickle ("bad") cells need to be removed because they get "trapped" in the liver where they are disposed of. These cells don't live as long as normal red blood cells, so the liver is working over time. ...Read more
Many: There are many autoimmune diseases. Some effect the skin, some the joints, some the kidneys, etc.. If you are having specific symptoms, you need to talk to your doctor about them to get a specific answer. ...Read more
Sickled RBC's: The spleen not only helps in processing antigens to help wbc's fight infection, it also acts as a "stress test" for rbc's, weeding out the weaker and older ones for recycling. As rbc's "sickle", they cause clumps in the vessels, this is what causes the pain in the joints/chest and also what causes the spleen to swell. If happens in the coronary arteries, can weaken the heart and enlarge it. ...Read more
Possibly: There are a lot of reasons for leukopenia. Usually isolated low white cells is not a sign of leukemia if the red blood cells and the platelets also found in blood are fine. Leukopenia develops in leukemia because all the bone marrow cells that eventually end up in the blood stream are crowded out by leukemia cells. ...Read moreSee 1 more doctor answer
In Situ or Invasive: Paget's dz represents less than 5% of all breast cancers; cancer cells are found involving the skin of the nipple, resembling eczema.Over 95% of the time an underlying cancer is found elsewhere in the breast, more commonly in-situ rather than invasive. Traditional rx was mastectomy however central lumpectomy (removal of nipple and areola) followed by radiation therapy is an acceptable alternative. ...Read more
Renal disease: It depends on what type of kidney disease. ...Read more
What does an increased number of mast cells in stress-indiced urticaria biopsy indicate? Previously diagnosed w/connective tissue autoimmune disease.
Which of the following are auto-immune conditions? Hypothyroidism Coeliac Disease Endometriosis Chronic Fatigue Syndrome (CFS)
Comments: We are learning that the immune system is playing a huge role in many known diseases, and Celiac is certainly auto-immune mediated, and several thyroid disorders are too. Chronic fatigue is often a manifestation of other disorders, and is not considered a separate disease per se. Am unaware of current concepts regarding endometriosis. Should ask OB-GYN specialist. ...Read more
There are: People with autoimmune disease can get better with pregnancy - this is seen especially with rheumatoid arthritis most of the time. Lupus can also improve or get worse, but it depends on the involvement of the lupus and what organ sites are involved. We are cautious with our pregnant patients, follow them along with high risk OB specialists and monitor their organ involvement. ...Read more
CLL: Cll is a clonal disorder (cancer) of the white blood cells (specifically lymphocytes) in the blood (= -emia part). Other leukemias include cml, aml, all, etc. Cll is often diagnosed by flow cytometry on peripheral blood. Additional studies may include ct scans and bone marrow biopsy. One staging system is rai 0 to iv. Treatment ranges from observation (rai 0-1) to various tx individualized to pt. ...Read moreSee 1 more doctor answer
What are the causes of hematological malignancies? What is the leading cause for hematological malignancies, such as leukemia or lymphoma?
Hard to say...: Many times we don't know what causes leukemia or lymphoma, irrespective of type. The process is probably multifactorial and has a strong genetic component. In a small subset of cases exposure to various toxins like paint fumes, or to radiation, can also cause it, but this represents only a small percentage of patients. There is also an association with certain viruses (ebv, htlv). ...Read moreSee 1 more doctor answer
See below: Some hereditary problems called leukodystrophies, association with toxins, like glue sniffing, medication reactions, such as anti-cancer drugs. And, of course, many peripheral nerve problems which can demyelination of distal nerves, such as chronic inflammatory demyelinating radiculoneuropathy. ...Read more
Yes: Yes, potentially by three mechanisms: first, a percentage of patients with Crohn's disease will have an inflammatory arthritic component to it that can affect the bones; second, patients with Crohn's can have malabsorption of some of the key nutrients that make bone string; and third, some of the medications used to treat Crohn's can impact bone health. Discuss with your doctor. ...Read moreSee 3 more doctor answers
Pancreas: The simple answer is yes (environment), and yes (hereditary), but it could be nothing or something unrelated. I suggest you have your PC refer you to a gastroenterologist. ...Read more
Is angioimmunoblastic t-cell lymphoma still treatable if in the marrow, anemia, low platelets, swelling?
T cell lymphoma: It is treatable but need careful supervision under the oncologist as chemo can be detrimental with low blood counts but sometimes that is the only way marrow can be cleared of lymphoma so lot of thinking needs to be done in selecting appropriate chemo for such patients. ...Read moreSee 1 more doctor answer
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