Doctor insights on:
Androstenedione Response To Acth
Test adrenal fxn.: This test is to check on whether or not your adrenal glands are working right. The acth action is to increase production and release of corticosteroids. In the test, a small amount of synthetic acth is injected and the amount of cortisol the adrenals produce in response is measured. This is used to check for things like primary and secondary adrenal insufficiency, and addison's disease. ...Read more
It is one of several pituitary hormones - acth for short (the others control the thyroid gland, gonad glands, and others) that controls adrenal gland function in primarily making the hormone called cortisol (not to be confused with "adrenaline"), though the adrenal gland also ...Read more
Trying to concieve. Mildly high level of androstenedione, testosterone, PRG-17-OH and Dhea So4. Is this serious?
Taking acth simulation test next week
CAH: Hi. It sounds like you may have a condition called non-classical congenital adrenal hyperplasia (CAH) due to a sluggish enzyme activity (21-hydroxylase). This can interfere with periods and fertility, and can cause hirsutism. Any of those things going on? The ACTH stim test can tell if 17(OH)progesterone and androtenedione go up out of proportion to the rise in cortisol. Good luck! ...Read more
Poor correlation: Hi. Oral cortisol (aka hydrocortisone) does not reliably affect ACTH secretion nor aldosterone levels. That is somewhat unfortunate for those of us treated adrenal insufficiency, since determination of proper dose is based solely on clinical response, and not labs. Aldosterone is driven by the renin-angiotensin system bypassing the pituitary. UIHC is excellent, so you have great docs close at hand ...Read more
Adrenal gland: yesGet a more detailed answer ›
How to know either it's from adrenal or pituitary gland that cause my hypocortisolism MRI pituitary normal. Acth level low.H/o exogenous steroid 2010.
Stimulate adrenals: Have your doctor do an adrenal stimulation test to check your adrenal response. Acth levels are often inaccurate and frequently not diagnostic. If you're on cortisone replacement already, it doesn't make much difference what the cause is, however your pituitary function can be analyzed one hormone at a time. Check w/an endocrinologist. ...Read more
ACTH ALDO Cortisol: I have seen two families in which ACTH is the major driver for aldo production. They have the syndrome called GRA (Glucocorticoid Remedial Aldosteronism) caused by a cross over mutation in the genes controlling aldo production so that the major controller of aldo is ACTH. As you are young and making this question if you also have HTN your team should consider this. Many do not have low K. ...Read moreSee 1 more doctor answer
Had poor cortisol& growhormone response to glucagon stim test.Could poor response be due to nutritional deficiencies?How could I confirm. Cort&GH low.
More testing: if you failed the test you could indeed have a GH deficiency. You need to get a full lab evaluation to determine the cause. See an Age Management Physician. ...Read more
Suspected ai, low salivary cortisol, low 24hr urinary cortisol, going for 8am serum cortisol and acth. Fast prior to bl. Work?
Generally not: Necessary, but check w/your specific lab to make sure of their requirements. ...Read more
Yes: Glandulars have been a traditional source of these hormones, but there absorption is not realiable. Check with your doctor or check out acam which is an organization that has investigated and held standards on hormone supplementation. They even have a physician referral on there website. ...Read moreSee 1 more doctor answer
If high cortisol can decrease serotonin levels then can low cortisol(like due to iatrogenic adrenal suppression) increase serotonin levels?
In general, no.: Too difficult to answer in 400 words, but confirmation of addison's requires a sequence of testing which must be performed and collected under standard protocols. Generally low cortisol with very high acth should suggest primary adrenal insufficiency - addison's disease. Anything else will require further testing to help sort out the various causes of low cortisol. ...Read more
Could my hypothalamus be giving orders to the adrenals to produce a surge of cortisol in response to my myasthenia gravis?
Why does acetylcholine, an inhibitory neurotransmitter, cause the adrenal glands to release stimulatory hormones?
Not correct: Hi. Acetyl choline (ACh) is not an inhibitory neurotransmitter. The sympathetic nervous system uses ACh as the neurotransmitter in the sympathetic ganglia (the 1st synapse outside the CNS). Usually that's from one neuron to another, but in the adrenal medulla, the cells are really the second neuron, but they release their contents (catecholamines) into the blood, not onto an organ (like the heart) ...Read moreSee 1 more doctor answer
Ovarian progesterone: Progesterone (ovarian) and dhea are the precursors for more specialized steroid hormones, including cortisol, aldosterone, estrogen and testosterone. Taking synthetic progesterone, progestin, will not increase the level of these hormones. In fact, Progesterone opposes their toxic effects. ...Read moreSee 1 more doctor answer
What pituitary hormones cause the adrenal gland to produce mineralocorticoids, glucocorticoids, and androgens and estrogens including pregnenolone?
Pituitary & steroids: Hi. Pituitary ACTH regulates adrenal cortisol production; it also acutely stimulates aldosterone, but is not the principle regulator. LH principally stimulates gonadal steroid hormone production (both genders make androgens & estrogens, but in opposite dominance). Pregnenolone is early in the steroidogenic pathway in both adrenals and gonads. Good luck! ...Read more
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