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Doctor insights on: Androgen Insensitivity Syndrome In Children

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What does androgen insensitivity syndrome mean?

What does androgen insensitivity syndrome mean?

XY baby is a girl: Without testosterone (t), all babies develop as girls. So a child with 1 x & 1 y chromosome, who would normally be a boy, would develop as a girl if no t was present. In androgen insensitivity syndrome, the t is there, but the cells are insensitive to it, and don't respond, so it's as if the t was not there at all. So an xy genetic boy baby is born looking like a normal healthy baby girl. ...Read more

Dr. Gary Greenly
19 doctors shared insights

Androgen Insensitivity Syndrome (Definition)

It is also called infertile male syndrome caused by androgen receptor gene mutation. As a result, such men have no or low sperm count and high or normal gonadotropin & testosterone. Testicular biopsy shows complete no germinal cell or sperm maturation arrest. History P+ physical exam + blood testing for gonadoteopin / testosterone + testicular ...Read more


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What is partial androgen insensitivity syndrome?

What is partial androgen insensitivity syndrome?

It's complicated!: Patient born with poor testosterone action, so a male patient is female-appearing, and is usually raised by the family as a female. Big changes at puberty, however, with breast development, but also enlargement of the clitoris which can be quite alarming, and other male sex characteristics. Removal of the testicles can preserve female body identity and appearance in this disorder. ...Read more

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Can you tell me about androgen insensitivity syndrome?

Can you tell me about androgen insensitivity syndrome?

AIS: Defects in androgen receptor function cause a disorder of sex development in which 46,XY individuals do not virilize normally, despite the presence of bilateral testes and serum testosterone concentrations within or above the normal male range. The presentation varies from Complete or Partial Androgen Insensitivity Syndrome with variable phenotypes. ...Read more

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What age do you suspect androgen insensitivity syndrome?

What age do you suspect androgen insensitivity syndrome?

Puberty: Usually, xy babies are born looking like healthy baby girls. During puberty, however, they don't develop secondary sexual characteristics that require testosterone such as axillary or pubic hair. Since estrogen is present, they grow breasts and develop a thin waist with larger hips, but don't have periods since they lack a uterus. Most often, lack of periods by age 15 or 16 leads to the diagnosis. ...Read more

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Does anyone famous have androgen insensitivity syndrome?

Does anyone famous have androgen insensitivity syndrome?

I bet you the answer: To that is yes, but i'm not sure they'll do a commercial about it... ...Read more

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What is androgen insensitivity syndrome and how will it affect me?

A.I.S. Quick Answer: Androgen insensitivity syndrome (ais) is when a person who is genetically male (who has one x and one y chromosome) is resistant to male hormones (called androgens). As a result, the person has some or all of the physical traits of a woman, but the genetic makeup of a man.

The effect of androgen insensitivity is potentially quite profound. ...Read more

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What are tests for androgen insensitivity syndrome in a young person?

It's complicated!: Androgen insensitivity syndrome is an extremely complex disorder due to failure of development in the genital area, with sometimes dramatic changes at puberty. Due to complex issues with gender, anatomy, and subsequent treatment, questions about this disorder should be addressed with a pediatric endocrinology consultation. ...Read more

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What is the definition or description of: Androgen insensitivity syndrome?

What is the definition or description of: Androgen insensitivity syndrome?

Here are some ...: It is also called infertile male syndrome caused by androgen receptor gene mutation. As a result, such men have no or low sperm count and high or normal gonadotropin & testosterone. Testicular biopsy shows complete no germinal cell or sperm maturation arrest.
History P+ physical exam + blood testing for gonadoteopin / testosterone + testicular biopsy confirm its diagnosis. ...Read more

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What is the treatment for androgen insensitivity syndrome?

What is the treatment for androgen insensitivity syndrome?

Can be Complicated: Complete ais isn't usually discovered until a girl fails to menstruate & has little or no pubic/underarm hair. No uterus, but those w/cais have intraabdominal testes which are removed because of cancer potential. Female by default as they can't respond to androgens in utero. Partial ai: babies are born with variable degrees of virilization. Assigning sex can be complicated. ...Read more

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Are people with androgen insensitivity syndrome intersex?

Variable features: Androgen insensitivity may lead to a normal looking female or, with partial insensitivity, testicles may be present. If a female, she will be infertile. Go to pubmed health for more detailed information. ...Read more

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What is androgen insensitivity syndrome? A genetic condition?

What is androgen insensitivity syndrome? A genetic condition?

Genetic: The androgen insensitivity syndrome is a genetic condition in which the cells of a genetic male (i.e. Born with an x and a y chromosome) do not respond to testosterone so that the patient develops the external bodily appearance of a female. ...Read more

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Can women with androgen insensitivity syndrome get pregnant?

No: Women with androgen insensitivity do not have internal female organs-- no uterus or fallopian tubes. Their gonads are testes, not ovaries. Externally, they have the appearance of normal females, but do not develop pubic or underarm hair. ...Read more

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Why can't people with androgen insensitivity syndrome handle testosterone?

Why can't people with androgen insensitivity syndrome handle testosterone?

Resistant to it: There is a genetic resistance to testosterone which can be partial or complete. Go to pubmed health for a detailed explanation. ...Read more

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What is androgen insensitivity syndrome in simple words possible for parents?

XY baby is a girl: Without testosterone (t), all babies develop as girls. So a child with 1 x & 1 y chromosome, who would normally be a boy, would develop as a girl if no t was present. In androgen insensitivity syndrome, the t is there, but the cells are insensitive to it, and don't respond, so it's as if the t was not there at all. So an xy genetic boy baby is born looking like a normal healthy baby girl. ...Read more

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Androgen insensitivity syndrome issue. What kind of doctor should I see about this?

An Endocrinologist: Androgen insensitivity syndrome (ais) is when a person who is genetically male (who has one x and one y chromosome) is resistant to male hormones (called androgens). As a result, the person has some or all of the physical traits of a woman, but the genetic makeup of a man. ...Read more

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Do women with androgen insensitivity syndrome have normal periods?

No.: During puberty, girls with androgen insensitivity syndrome don't develop secondary sexual characteristics that require testosterone such as axillary or pubic hair. Since estrogen is present, they grow breasts and develop a thin waist with larger hips, but don't have periods since they lack a uterus. Most often, lack of periods by age 15 or 16 leads to the diagnosis. They cannot become pregnant. ...Read more

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I am missing a testicle from birth. I suspect Androgen Insensitivity syndrome. I am 33, are people with AIS homosexual? I feel gay, but dont know 100%

I am missing a testicle from birth. I suspect Androgen Insensitivity syndrome. I am 33, are people with AIS homosexual? I feel gay, but dont know 100%

Here are some...: Sexual orientation deviating from genetic designation largely is acquired thing. If you found some uneasiness or uncertain in interacting with opposite sex but more inclined to go along with same sex, seek professional counseling from psychologist or someone being comfortable to discuss the matters of sex orientation. ...Read more

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What happens if a girl was born with androgen insensitivity syndrome, would it be possible for her body to develop a male pelvis?

What happens if a girl was born with androgen insensitivity syndrome, would it be possible for her body to develop a male pelvis?

Complicated: This is a complicated syndrome that can not be discussed in the 400 characters HealthTap docs are allotted. I would make sure the child is followed by a good pediatric endocrinologist. He/she is best to answer the complicated questions regarding a child with androgen insensitivity. ...Read more

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Can you tell me if a girl was born with androgen insensitivity syndrome, would it be possible for her body to develop a male pelvis?

Can you tell me if a girl was born with androgen insensitivity syndrome, would it be possible for her body to develop a male pelvis?

Sensitive question: There is an answer to this, but it is a sensitive subject, and should be answered by the patient's personal doctor, not in a public site such as this. Please consult your doctor. ...Read more

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What are the tests for androgen insensitivty syndrome?

Its Complicated: If this describes your condition: androgen insensitivity syndrome (ais) is when a person who is genetically male (who has one x and one y chromosome) is resistant to male hormones (called androgens). As a result, the person has some or all of the physical traits of a woman, but the genetic makeup of a man.

The tests include: testosterone, fsh, lh, genetic karotyping

see: endocrinologist. ...Read more

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Is androgen insensitivity like hermaphrodite?

Is androgen insensitivity like hermaphrodite?

No: Androgen insensitivity means that the receptors for testosterone type of hormones (t) cannot respond to t stimulation. In more severe cases infants with xy chromosomes (typically male) may develop female genitalia during fetal development because if this. They are likely to be raised as females with a diagnosis only coming after they don't get sexual hair or periods. ...Read more

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I don't understand androgen insensitivity.?

Genetic condition: In androgen insensitivity syndrome the patient is genetically male (i.e. Has both an x and a y chromosome), but the tissues do not respond normally to male hormones in the course of development, so the external body appearance is closer to that of a female. ...Read more

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Does androgen insensitivity converts a guy into a girl?

Default: Complete ai is no response to testosterone (t). In pregnancy with a male fetus, genital development relies on fetal t production. When fetus can't respond to t, external genitals become female by default. Testes are intraabdominal. Girls often aren't diagnosed w/ai until failing to develop sexual hair and don't have periods. No uterus. +breasts as testosterone converts to estrogen. ...Read more

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How does one test for partial androgen insensitivity? Is it something a doctor can easily create an order to be tested in labcorp/quest?

How does one test for partial androgen insensitivity? Is it something a doctor can easily create an order to be tested in labcorp/quest?

Just an idea: I may have been the one who had the idea. Androgen insensitivity ranges from XY males who look like females, through men with ambiguous genitalia or hypospadias, and probably to guys who just never become quite as masculinized as others. An endocrinologist can sort things out, but testing is specialized and since there's really no Rx, perhaps not useful. Best wishes; hope you get what you want. ...Read more

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What s the best medication for the problem androgen insensivity? Thank you.

Is the Dx correct?: If this describes your condition: androgen insensitivity syndrome (ais) is when a person who is genetically male (who has one x and one y chromosome) is resistant to male hormones (called androgens). As a result, the person has some or all of the physical traits of a woman, but the genetic makeup of a man.

The tests include: testosterone, fsh, lh, genetic karotyping

see: endocrinologist. ...Read more

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How can one reduce high androgen levels in their bodies if you are a woman?

How can  one reduce high androgen levels in their bodies if you are a woman?

For most: Women it's because of obesity and Insulin resistance. Diet, exercise and weight loss will help. Metformin is often useful and there are antiandrogen medications available. Check w/your doctor. ...Read more

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What anti-androgen is best, and what are its common side-effects?

What anti-androgen is best, and what are its common side-effects?

Several for purpose?: Finsteride blocks many unwanted side-effects of testosterone, by blocking its conversion to 5-dht, which causes baldness (male pattern), prostatic hypertrophy, and excess hair growth elsewhere.
Minoxidil applied topically (rogaine) has a similar topical effect. Spironolactone also is effective! ...Read more

Androgen (Definition)

Androgen refers to a family of steroid hormones that are made in our bodies that are responsible for male characteristics, sex drive, muscle growth, sexual function, and fertility. These hormones are present in women in very small amounts and in very ...Read more


Dr. Alvin Lin
1,755 doctors shared insights

Testosterone (Definition)

Testosterone is a hormone/androgen which is a kind of ...Read more