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Doctor insights on: Ana Titre 1 160

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I have recurring flares of rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back. My ANA is 6:40. I'm on plaquenil. Why are all my other antibodies neg for lupus?

I have  recurring flares of  rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back.  My ANA is 6:40.  I'm on plaquenil. Why are all my other antibodies neg for lupus?

Maybe SLE maybe not.: Diagnosis of rheumatologic disease is generally based on symptoms with support from lab. Sounds like you have a rheumatologic disease and are being treated with a rheumatologic agent perhaps by a rheumatologist. They can explain your particular situation better, but suffice it to say tests are not always right and a single test does not generally make or break a diagnosis. ...Read more

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Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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2 positive ANA titres 1:160 speckled. All manual diff tests neg. Is this something to worry about?

2 positive ANA titres 1:160 speckled. All manual diff tests neg. Is this something to worry about?

May be non-specific?: ANA is test for antibodies directed against nuclear antigens. A positive test screens for autoimmune diseases such as systemic lupus erythematosus. There are four patterns: homogenous, nucleolar, peripheral, and speckled. Low titers less than 1:160 is likely a non-specific response. The clinical importance of this is to be decided in the light of other findings, and a follow-up test for direction. ...Read more

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I have ANA testing speckeled pattern, titre 1.160 and suggesting either could that include rheumatoid arthritis?

I have ANA testing speckeled pattern,  titre 1.160  and suggesting either could that include rheumatoid arthritis?

Anti-CCP: Speckled ANA at 1:160 is generally associated with connective tissue disease. There is a better test for rheumatoid arthritis, namely anti-ccp antibody. Do you have any symptoms? Every lab test needs to interpreted in the clinical context as some tests are falsely positive. See this site for more info. http://www.ncbi.nlm.nih.gov/pubmedhealth/pmh0001467/. ...Read more

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Should I be concerned if my S.Creatinine level rises from 1.02 mg/dl to 1.12 mg/dl in one months time if ANA is positive?

Should I be concerned if my S.Creatinine level rises from 1.02 mg/dl to 1.12 mg/dl in one months time if ANA is positive?

Follow it: Your history gives me no reason to think you have lupus. You might have taken ibuprofen, put on some extra muscle, or otherwise gotten your creatinine up for some reason. I trust your urinalysis is normal. I'd urge you to stay fit and not fret over small changes in lab values. ...Read more

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Could a positive ANA automatically mean one would need to be on steriods?

Absolutely not: The ANA is nonspecific and can be seen in numerous diseases and often in totally normal people. By itself, it is not a reason to start any medication. It needs to be evaluated in context of the clinical symptoms. ...Read more

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I have 10 out of 12 symptoms of lupus but a negative ana. Can my ANA be negative one time and positive another?

ANA negative SLE: About 5% of the patients with systemic lupus are ANA negative. Read the information at the site given below. Please discuss the issue with your doctor sle is not a topic for self diagnosis. http://www.lupus.org/webmodules/webarticlesnet/templates/new_aboutfaq.aspx?articleid=380&zoneid=19. ...Read more

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Which test is more preferred by doctors: the "ANA IFA" or the "ANA Direct?" Which one is more accurate of the two?

Different info: The tests are similar but differ in the details of information provided. A positive ANA, by itself is only a screening test and is not diagnostic of a disease. Further testing is usually needed, depending on the clinical picture. ...Read more

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Please I need help. I have most symptoms of lupus but negative ANA so no one wants to help me. Life is going down fast. Almost always bed fast. ?

Please I need help. I have most symptoms of lupus but negative ANA so no one wants to help me. Life is going down fast. Almost always bed fast. ?

See details: Have you seen a rhematologist? If not, do so. If you have, get a second rheumatology opinion. If the doc has ruled out lupus ask for your diagnosis and treatment options. ...Read more