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Doctor insights on: Ana Titre 1 160

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I have recurring flares of rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back. My ANA is 6:40. I'm on plaquenil. Why are all my other antibodies neg for lupus?

I have  recurring flares of  rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back.  My ANA is 6:40.  I'm on plaquenil. Why are all my other antibodies neg for lupus?

Maybe SLE maybe not.: Diagnosis of rheumatologic disease is generally based on symptoms with support from lab. Sounds like you have a rheumatologic disease and are being treated with a rheumatologic agent perhaps by a rheumatologist. They can explain your particular situation better, but suffice it to say tests are not always right and a single test does not generally make or break a diagnosis. ...Read more

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Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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2 positive ANA titres 1:160 speckled. All manual diff tests neg. Is this something to worry about?

2 positive ANA titres 1:160 speckled. All manual diff tests neg. Is this something to worry about?

Possibly: The ANA is not very specific. It can be possible in numerous diseases including viral diseases. It can also be positive in individuals without any disease. The ANA needs to be interpreted in the clinical setting to be properly evaluated. ...Read more

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I have ANA testing speckeled pattern, titre 1.160 and suggesting either could that include rheumatoid arthritis?

I have ANA testing speckeled pattern,  titre 1.160  and suggesting either could that include rheumatoid arthritis?

Anti-CCP: Speckled ANA at 1:160 is generally associated with connective tissue disease. There is a better test for rheumatoid arthritis, namely anti-ccp antibody. Do you have any symptoms? Every lab test needs to interpreted in the clinical context as some tests are falsely positive. See this site for more info. http://www.ncbi.nlm.nih.gov/pubmedhealth/pmh0001467/. ...Read more

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Should I be concerned if my S.Creatinine level rises from 1.02 mg/dl to 1.12 mg/dl in one months time if ANA is positive?

Should I be concerned if my S.Creatinine level rises from 1.02 mg/dl to 1.12 mg/dl in one months time if ANA is positive?

Follow it: Your history gives me no reason to think you have lupus. You might have taken ibuprofen, put on some extra muscle, or otherwise gotten your creatinine up for some reason. I trust your urinalysis is normal. I'd urge you to stay fit and not fret over small changes in lab values. ...Read more

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Could a positive ANA automatically mean one would need to be on steriods?

Could a positive ANA automatically mean one would need to be on steriods?

Absolutely not: The ANA is nonspecific and can be seen in numerous diseases and often in totally normal people. By itself, it is not a reason to start any medication. It needs to be evaluated in context of the clinical symptoms. ...Read more

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I have 10 out of 12 symptoms of lupus but a negative ana. Can my ANA be negative one time and positive another?

ANA negative SLE: About 5% of the patients with systemic lupus are ANA negative. Read the information at the site given below. Please discuss the issue with your doctor sle is not a topic for self diagnosis. http://www.lupus.org/webmodules/webarticlesnet/templates/new_aboutfaq.aspx?articleid=380&zoneid=19. ...Read more

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Which test is more preferred by doctors: the "ANA IFA" or the "ANA Direct?" Which one is more accurate of the two?

Different info: The tests are similar but differ in the details of information provided. A positive ANA, by itself is only a screening test and is not diagnostic of a disease. Further testing is usually needed, depending on the clinical picture. ...Read more

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What is the difference between the anachoice screen and the ANA screen, ifa? The first one came back positve, but the second came back negative.

IFA better: For a screen the ifa is much better. It is the gold standard. The ANA choice is not a screening test and should not be offered as a screening test. Your question is somewhat counter intuitive. The ifa is a better test and if choice is positive - it can be subseted into 12 antigens and the lab can tell you. I would follow your test results with ANA subsets per your rheumatologist. ...Read more

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What is the difference between the anachoice screen and the ANA screen, ifa? The first one came back positve, but the second came back negative.

What is the difference between the anachoice screen and the ANA screen, ifa? The first one came back positve, but the second came back negative.

Diff. lab techniques: Different labs have different ANA tests, which is a test for antibodies a person makes that attach to his own body's tissues, that end up causing auto-immune disease. Modern tests use "reflex" or "cascade" techniques, meaning one test is done first, and then if positive, another test is done, and then if positive again, a third test is done. Tests have various "positive" ranges (gets complicated). ...Read more

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Please I need help. I have most symptoms of lupus but negative ANA so no one wants to help me. Life is going down fast. Almost always bed fast. ?

Please I need help. I have most symptoms of lupus but negative ANA so no one wants to help me. Life is going down fast. Almost always bed fast. ?

See details: Have you seen a rhematologist? If not, do so. If you have, get a second rheumatology opinion. If the doc has ruled out lupus ask for your diagnosis and treatment options. ...Read more

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What is the difference between an ANA and ELISA test? I tested high positive for one and negative for the other. Please explain in simplest terms. TY!

ANA vs ELISA: Well ANA is a protein produced by our immune system in various situation. ELIZA is method which uses to identify and detect ANA. There is also another method used to detect ANA. In 2nd method the titer is reported too rather then saying it's positive or negative. ...Read more

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Can being on a pro ANA website negatively effect health even when one is not suffering from an eating disorder?

Can being on a pro ANA website negatively effect health even when one is not suffering from an eating disorder?

It can: If the frequent visit to the website implies an excessive worry about eating and weight gain, it could constitute one criteria for an eating disorder. It depends. ...Read more

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In a diagnosis of mixed connective tissue disease, is it the anas alone that makes one feel crummy during flares if the other labs are normal?

In a diagnosis of mixed connective tissue disease, is it the anas alone that makes one feel crummy during flares if the other labs are normal?

Not likely so..: Antinuclear antibodies (ANA) is helpful in the innitial work-up and diagnosis of a rheamatologic disease, but ANA does not indicate the level of disease actitivies. Once positive for ana, this will always be so. The esr, crp, rf (in rhematoid arthritis) levels do correlate with disease activities and likely how you feel. U should check for thyroid, lyme, mono, depression, insomnia etc..Good luck. ...Read more

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What are the statistics regarding 3 people in one immediate family being affected by lupus? Dr suspects my 16 yo (high ANA etc)-3rd in family

Possibility increase: Because there is a hereditary componenet involved in systemic lupus, other family members may also be affected. However, close relatives of individuals with lupus may have a positive ANA without clinical disease. Your daughter needs an evaluation by a rheumatologist if she has not undergone one already. ...Read more

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Would a +ANA only occur when you have the symptoms of a autoimmune disease. I had ANA test a while back it was neg. Then had another one it was pos?

Other causes: There are a number of conditions that can cause an elevated ANA besides Autoimmunitiy. I could just be temporary. ...Read more