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Doctor insights on: Ana Positive Lupus

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I have a positive ana, positive lupus anticoagulant, 386 value for microsomal antibodies. C3 of 113, C4 of 53. A rash on face could it be lupus?

I have a positive ana, positive lupus anticoagulant, 386 value for microsomal antibodies. C3 of 113, C4 of 53.  A rash on face could it be lupus?

Yes: If the rash fits the butterfly or discoid rash or the subacute lupus skin lesion. ANA titer is usually high in lupus; you have not listed yours. The c3 and c4 are markers of disease activity and famously nonspecific. Don't try to self-diagnose; your age of 54 is a bit high for new-onset lupus though it's not impossible. ...Read more

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Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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I have symptoms of behcets and lupus.Neg ana, but positive lupus skin biopsy. Could i still have lupus?

I have symptoms of behcets and lupus.Neg ana, but positive lupus skin biopsy. Could i still have lupus?

Unlikely: Technically yes, but practically no, at least not the systemic form. I cannot remember the last time i saw ANA negative systemic lupus but anything is possible. ...Read more

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I have middle back pain that has been there for months. Burning feeling also same in right flank. Ana positive 1:640 . Lupus panel neg. What is this?

I have middle back pain that has been there for months. Burning feeling also same in right flank. Ana positive 1:640 . Lupus panel neg. What is this?

Joint or nerve: The pain can be from a number of locations depending site and referral of pain. If primarily in midline of back and then travels across rub cage it could be disc issue or an intercostal nerve pain. Identify if back pain is at same level as referred flank pain. Make sure to rule out any abdominal issues which may be related to eating, bowel movements, urination, also consider a muscle issue. ...Read more

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Why did a neurologist automatically assume depression, (numbness, vision problems, fuzzy memory) after negative mri? Ana positive. Gp says lupus.

Why did a neurologist automatically assume depression, (numbness, vision problems, fuzzy memory) after negative mri? Ana positive. Gp says lupus.

Depends: Lupus causing central nervous system findings is advanced & has unequivocal lab findings 2 go with significant physical findings. A positive ANA is not diagnostic of anything specific. If you had lupus causing CNS abnormalities, many other autoimmune tests are likely to be extremely elevated. Lupus would have joint & kidney findings too. Anxiety or depression are more common & likely the reason. ...Read more

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I was diagnosed with partisans in 2007. Went to my gprs yesterday and he informed me that my ANA was positive for lupus.. Is it possible to have both?

I was diagnosed with partisans in 2007. Went to my gprs yesterday and he informed me that my ANA was positive for lupus.. Is it possible to have both?

Possible: Anything is possible but remember the ANA is a nonspecific test and can be positive in numerous other diseases and even in normals. Why was the test done in the first place? If unsure about lupus, see a rheumatologist. ...Read more

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I'm ana-positive; could I have lupus without any symptoms?

See a Rheumatologist: This really needs to be discussed with a rheumatologist who can take a complete history and do a physical exam. In addition he or she will need to do additional laboratory tests before making the diagnosis of lupus or ruling it out. ...Read more

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Will a positive ANA necessairly mean lupus?

No: A positive ANA alone does not make one have lupus. Other criteria must be met to be labeled with lupus. ANA can often be false positives. ...Read more

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How often does an ANA test comeback positive when lupus is not involved? What else could a positive ANA indicate? (there are several symptoms of sle)

How often does an ANA test comeback positive when lupus is not involved? What else could a positive ANA indicate?  (there are several symptoms of sle)

Positive ANA: A positive ANA can mean many things. Lupus is just one autoimmune disorder. An ANA can come back positive and be rechecked and be negative. There are other blood markers that we use to tell what an ANA means. Ask your doctor if other tests were done. ...Read more

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Fatigue, weight gain, hair loss, swollen glands, bloated abdomen and legs, positive ANA test, negative lupus test, normal thyroid test...Help?!?

Fatigue, weight gain, hair loss, swollen glands, bloated abdomen and legs, positive ANA test, negative lupus test, normal thyroid test...Help?!?

See details: Your symptoms are not really specific but the positive ANA can be significant. See a rheumatologist. Is lupus possible in this setting? Yes, but that is only one possible diagnosis and the ANA by itself needs to be evaluated in the context of the entire clinical picture. ...Read more

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Will my ANA test positive if my lupus is mild?

Yes: The degree of ANA positivity does not correlate with disease activity. ...Read more

Dr. James Chapman
3 doctors shared insights

Systemic Lupus Erythematosus (Definition)

Lupus erythematosus is a name given to a collection of autoimmune diseases, in which the human immune system becomes hyperactive and attacks normal, healthy tissues.Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood ...Read more