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Doctor insights on: Ana Ifa Screen With Reflex To Titer

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Positive ANA IFA screen with reflex is it contagious?

Positive ANA IFA screen with reflex is it contagious?

Antibodies: A positive ANA means antibodies which can react with your body's cells. They can form after an infection, but do not indicate anything about the infection which is usually long since gone. There are many, many people whose ANA is positive and very, very few who have actual autoimmune disease. The question to ask is: for what symptoms was the ANA ordered? ...Read more

Dr. Scott Keith
3 Doctors shared insights

Ana Ifa Screen (Definition)

Anti-nuclear antibodies (anas) are autoantibodies directed against certain parts of a cell nucleus. Anas are present in increased amounts in a variety of autoimmune diseases. An ANA test measures the pattern and amount of these autoantibodies that can attack the body's tissues as if they were foreign. An indirect fluorescent antibody (ifa) test is one that uses ...Read more


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What is the definition or description of: ANA ifa screen?

A lab test.: Anti-nuclear antibodies (anas) are autoantibodies directed against certain parts of a cell nucleus. Anas are present in increased amounts in a variety of autoimmune diseases. An ANA test measures the pattern and amount of these autoantibodies that can attack the body's tissues as if they were foreign. An indirect fluorescent antibody (ifa) test is one that uses two antibodies for detection. ...Read more

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Ana titer with reflex to ifa of 1:320 and neg for antibody tests what does that mean? Pattern was speckled and homogeneos

Ana titer with reflex to ifa of 1:320 and neg for antibody tests what does that mean? Pattern was speckled and homogeneos

See details: You have a positive ANA which is a screening test for lupus. However, it is positive in numerous other diseases and even in normal people. See a rheumatologist to determine what it means. ...Read more

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How about Ana screen positive, Ana titer (ifa) 1:80 Hi, and pattern speckled?

How about it?: Up to a quarter of women your age have an ANA (immunofluorescent antibody) at a low titer like yours with a speckled pattern. If there's a question of whether you have lupus or one of its relatives, it's a piece of information to note and file for future reference. A negative ANA would rule several things out. Your result proves nothing positive. Best wishes. ...Read more

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My teen had ANA test but now dr is saying we need a "reflex titer" blood test. What is it and does that mean ANA positive?

Suggestive of auto-: Immune disorder. A high concentration of anti-nuclear antibody is one indicator or auto-immune disease. Titer is one expression for concentration of a particular antibody. See this site for info on ana:
http://www. Nlm. Nih. Gov/medlineplus/ency/article/003535.Htm. ...Read more

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What does titer with 180H with ANA IFA positive and homogeneous pattern mean?

ANA explanation: ANA are antinuclear antibodies which are seen in Systemic Lupus and some other disorders. Titer means how many dilutions in the test are still positive. The higher the number the more significant the test is clinically. 1:10-1:40 is low; 1 :80-1:320 is modest;1:680 and higher is high and very significant. Homogeneous is the most non-specific pattern seen even in drug-induced SLE. See your above. ...Read more

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Ana screen positive, ANA titer 320, rash very often on face, nucleolar pattern. Any significance?

Yes: The pattern is not important but a facial rash and a positive ANA suggest the possibility of some form of lupus. ...Read more

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Rashes on neck (not butterfly) gone after use of steroid cream (5 days), ANA IFA positive, Pattern :Homogeneous, Titer : 1:80h, should I be worried?

Rashes on neck (not butterfly) gone after use of steroid cream (5 days), ANA IFA positive, Pattern :Homogeneous, Titer : 1:80h, should I be worried?

No: A titer of 1:80 is borderline at best and is likely unrelated. However, if the rash is recurrent see a dermatologist and have it biopsied. Then you will know for certain. ...Read more

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I TOOK SOME LABS ANA SCREEN "YOUR VALUE" SAYS SEE TITER, HEX LUPUS ANTICOAGULANT IS 6 (NEGATIVE), SED RATE 3 AND ANA QUANT IS 320. WHAT DOES THIS MEAN?

Upload onto HT Prime: Rather than getting into hypotheticals in this forum (that's lmtd to 400 characters), you're best off starting a consult in HealthTap Prime. If you've obtained a computer copy of the lab results, as you'll be able to upload it in HealthTap Prime using the paperclip icon. You'll also get a doctor to go over it with you LIVE. You can ask questions & get responses in real time. It'll give best answer ...Read more

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Hx of seronegative RA yet recent labs show high crp/esr, absolute neutrophils and ANA by IFA but w/ no titer. What could that mean without a titer?

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your lab results suggest active on-going inflammation. The titer of ANA is not particularly relevant.
Wish you good health. ...Read more

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C reactive protein 0.81h Ana screen, IFA positive Ana pattern homogeneous Ana titter 1:80H What's wrong with me?

Maybe nothing: C reactive protein is famously insensitive and nonspecific. Many young women have an ANA titer like yours. The diagnosis, if one is to be made, will be on history and physical exam. ...Read more

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Ana screen, ifa positive a (negative) means?

Nothing by itself: One person in four tests positive. The vast majority of these people have no problems. The clinical picture is key, and how high the titer is may be helpful. ...Read more

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What does a positive ANA screen ifa and dual ANA pattern mean?

ANA: ANA test is a screening test to diagnose auto immune diseases especially lupus. ANA stands for anti nuclear anti bodies directed against nuclear components called antigens. Ifa stands for immuno fluorescent assay. There patterns that develop based on which anti body is directed against which antigen and such patterns are called homogenous, nucleolar etc signifying different disease patterns. ...Read more

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What is the difference between the anachoice screen and the ANA screen, ifa? The first one came back positve, but the second came back negative.

IFA better: For a screen the ifa is much better. It is the gold standard. The ANA choice is not a screening test and should not be offered as a screening test. Your question is somewhat counter intuitive. The ifa is a better test and if choice is positive - it can be subseted into 12 antigens and the lab can tell you. I would follow your test results with ANA subsets per your rheumatologist. ...Read more

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What is the difference between the anachoice screen and the ANA screen, ifa? The first one came back positve, but the second came back negative.

What is the difference between the anachoice screen and the ANA screen, ifa? The first one came back positve, but the second came back negative.

Diff. Lab techniques: Different labs have different ANA tests, which is a test for antibodies a person makes that attach to his own body's tissues, that end up causing auto-immune disease. Modern tests use "reflex" or "cascade" techniques, meaning one test is done first, and then if positive, another test is done, and then if positive again, a third test is done. Tests have various "positive" ranges (gets complicated). ...Read more

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I have a lab result of positive ANA screen, ifa. Ana pattern is speckled and ANA tilter is 104H. Is this of concern. Have fingers and toes draw up.

I have a lab result of positive ANA screen, ifa. Ana pattern is speckled and ANA tilter is 104H. Is this of concern. Have fingers and toes draw up.

Big picture: About one grown woman in four has detectable antinuclear antibodies. They are only on part of the workup for your back pain / fatigue. For most people, they are of no consequence. They are of course the basic screening test for lupus and for a few other illnesses, but you're not a lupus patient yet. Best wishes -- stay proactive and keep asking these good questions. ...Read more

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Had HSV DNA PCR test with CSF? Negative. Also had HSV 1/2 antibody (IgM), IFA with reflex to Titer, CSF. Negative. Can I still have HSV 1 or 2?

Had HSV DNA PCR test with CSF? Negative. Also had HSV 1/2 antibody (IgM), IFA with reflex to Titer, CSF. Negative. Can I still have HSV 1 or 2?

No HSV in CNS: With these tests, you're obviously under a doctor's care, maybe including an infectious diseases specialist or neurologist. They can answer these questions best. But these results effectively rule out HSV infection of your central nervous system. Something else is causing the problem. That said, the HSV IgM test is notoriously unreliable. You probably also had an IgG test, probably negative. ...Read more

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Went to dr with hand, shoulder, hip joint pain. Ana reflex screen Ana positive 1.0 and rnp antibody positive 4.3. All others neg. Very scared!

Went to dr with hand, shoulder, hip joint pain. Ana reflex screen Ana positive 1.0 and rnp antibody positive 4.3. All others neg. Very scared!

Lab numbers: These numbers don't show changes at joints and with most auto immune disorders, you may have periods of pain and increased lab numbers, usually related to stress in your life, and once treated medically or with stress reduction, pain/lab should improve. May want xray of one of involved joints just inflamed which can return to baseline. ...Read more

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What is the IgG screen w/ reflex IFA performed for?

What is the IgG screen w/ reflex IFA performed for?

Many Things: This type of test is done for many types of infections, especially viruses or pertussis. In order to give you mroe information, I would need to know what specifically they were doing the test to check on. ...Read more

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Lupus? Ana titers are 1:320 and have not changed for 4 years. Ana screen is positive and speckled. I have low iron stores and mchc.

See details: An ANA is nonspecific and once positive it usually remains positive. Its importance must be evaluated in the context of the entire clinical picture. In the context of the symptoms you listed, lupus would be unlikely. ...Read more

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Do I have lupus? Ana screen came back as positive/abnormal. Ana titers are 1:320. Dna test came back as normal. My mchc is low and so are my iron stor

Do I have lupus? Ana screen came back as positive/abnormal. Ana titers are 1:320. Dna test came back as normal. My mchc is low and so are my iron stor

Connective tissue dz: This finding show that you have some kind of connective tissue disease and could be lupus. But you should discuss with your pcp and make further plan for treatment. ...Read more

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Positive ANA, 1:640 titer, mixed speckled & homgeneous pattern, Neutrophil 63.2%. Thoughts???

You might suffer: From an autoimmune disease, you need additional tests to define what kind. A rheumatologist should see you ...Read more

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A positive ANA test 1;320 titer, with a speckled pattern... Does it mean I have an autoimmune disease...

Not necessarily: The ANA is a screening test for lupus but is not specific. It can be positive in numerous other diseases and in normal people. It has to be evaluated in the context of the clinical picture and the results of other autoantibody tests. ...Read more

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A positive ANA of 1:80 titer Nucleolar pattern, 36 RF, 22 Sedimentation rate and a 3.0 hsCRP...could this be something?

Nonspecific: This level of ANA is nonspecific but may be indicative of a mild autoimmune disorder but has to be interpreted in context of symptoms and physical findings. Your sed rate is not elevated and if you have no other findings, I doubt you have active inflammatory process going on. A rheumatologist is best qualified to evaluate and advise you about your status. ...Read more

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What do you think? Ana-positive, titer >1:640, speckled/ana titer 2-1:32, ANA pattern 2-homogeneous c3 180.8, rnpab, IgG 1.5, CRP 1.9.

Possible MCTD: The highly positive ANA in a speckled pattern suggests mixed connective tissue disease. Mctd is a close cousin of lupus but usually has a better prognosis. The anti-rnp is usually be elevated in mctd. Interpreting the results of autoantibody studies can confusing. You should discuss these findings with a rheumatologist. ...Read more

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Why do pcps tend to run direct ANA and rheum mds run ANA titers? Should pcps be running the titer instead when suspecting autoimmune condition?

Ana: Difference usually pcp screening for disease where rheumatology looking for severity of disease or following disease activity. Personally I order with reflex to titter. ...Read more

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Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Heads up: One of the things that's frustrating about these antibody tests looking for different connective tissue diseases is that they are difficult to do and are fraught with pitfalls. I suspect you've had at least one lab error to complicate your workup. Have you have a tube test for u1-rnp? Your clinical symptoms and signs actually tell more about your diagnosis ; best direction for treatment. ...Read more

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What does a positive result on the ANA titer mean?

Further testing: A positive ANA may not be significant. First of all why was the test done. If it was done for joint pain it will mean more then if a physiciab did one as a part of an annual physicial. Certainly, we are may be more concerned based on the value but also the pattern of the ana. The titer may mean an autoimmune disease is present based on the complaints, physical exam, and the values of other tests. ...Read more

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What does this mean (h) 1:8 titer, ANA patter (a) nucleolar, ANA screenifa (a) positive?

Depends on setting: The blood test by itself is not diagnostic. It depends on your clinical condition why the test was done as to whether it has any meaning at all. All this means is that you have an antibody against nucleus of the cell but that is not a diagnosis. ...Read more

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Can hashimotos cause an ANA titer of >1:1280 homogenous or is there something more going on. On meds for hypothyroidism currently.

Can hashimotos cause an ANA titer of >1:1280 homogenous or is there something more going on. On meds for hypothyroidism currently.

Yes: Yes, the presence of an autoimmune thyroid disease like hashimoto's can cause an elevated ANA titer, such as yours. Some patients in this situation never develop symptoms of other autoimmune diseases, but there is a subset of people who do. Have your doctor test you for other autoimmune antibodies such as ant ds-dna, anti-ro, and anti-la antibodies to name a few. ...Read more

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ANA pattern was Nucleolar. Can gout or reynauds cause this pattern? Can u be neg & STILL show an Ana pattern? Ana titer was 1:40, Esr of 30.

Whoa: This is a low-titer ANA. I'd ignore the pattern -- there may be lab errors. The sed rate is also not so high as to really be that useful. This is information to note, but we'll need more before we can diagnose / treat CREST, lupus, scleroderma. Gout and common Raynaud's are unrelated to ANA and the vast majority of folks with ANA's at this titer have no illness related to it. ...Read more

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My ANA Hep-2 Titer is >1280 Titer 1 and standard is <80 Titer 1. pattern is Centromere. I have lupus. Just how bad is this result? Common?

Lab tests: Both of these tests may be suggestive of lupus or other autoimmune conditions. However, the lab test are just 1 component of the overall assessment and does not by itself makes the diagnosis of lupus. I recommend seeing a rheumatologist and would be happy to consult if needed. ...Read more

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4 tests in 2 years show low titer ANA no symptoms nucloelar ENA negative test now ANA negative so am I now in category of no autoimmmune disease?

No problem: An isolated positive ANA does not constitute autoimmune disease. Not sure why the test was checked for initially, but in the absence of symptoms, I would not be concerned about an abnormal blood test result by itself. ...Read more

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Is a ANA titer of 1:640, homogenous considered high? Rhuemy said I might have sle but would never diagnose in a male. Should I get a 2nd opinion?

Is a ANA titer of 1:640, homogenous considered high? Rhuemy said I might have sle but would never diagnose in a male. Should I get a 2nd opinion?

See details: That ANA is positive. If the clinical picture fits then you have sle regardless of whether you are male or female. Being a male does not exclude the diagnosis. Get a 2nd opinion if you are concerned. ...Read more

Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more