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Doctor insights on: Ana Ifa Reflex Titer Pattern Cascade

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Ana titer with reflex to ifa of 1:320 and neg for antibody tests what does that mean? Pattern was speckled and homogeneos

Ana titer with reflex to ifa of 1:320 and neg for antibody tests what does that mean? Pattern was speckled and homogeneos

See details: You have a positive ANA which is a screening test for lupus. However, it is positive in numerous other diseases and even in normal people. See a rheumatologist to determine what it means. ...Read more

Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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How about Ana screen positive, Ana titer (ifa) 1:80 Hi, and pattern speckled?

How about Ana screen positive, Ana titer (ifa) 1:80 Hi, and pattern speckled?

How about it?: Up to a quarter of women your age have an ANA (immunofluorescent antibody) at a low titer like yours with a speckled pattern. If there's a question of whether you have lupus or one of its relatives, it's a piece of information to note and file for future reference. A negative ANA would rule several things out. Your result proves nothing positive. Best wishes. ...Read more

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What does titer with 180H with ANA IFA positive and homogeneous pattern mean?

ANA explanation: ANA are antinuclear antibodies which are seen in Systemic Lupus and some other disorders. Titer means how many dilutions in the test are still positive. The higher the number the more significant the test is clinically. 1:10-1:40 is low; 1 :80-1:320 is modest;1:680 and higher is high and very significant. Homogeneous is the most non-specific pattern seen even in drug-induced SLE.See your above. ...Read more

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Rashes on neck(not butterfly) gone after use of steroid cream( 5 days), ANA IFA positive, Pattern :Homogeneous, Titer : 1:80h, should I be worried?

Rashes on neck(not butterfly) gone after use of steroid cream( 5 days), ANA IFA positive, Pattern :Homogeneous, Titer : 1:80h, should I be worried?

No: A titer of 1:80 is borderline at best and is likely unrelated. However, if the rash is recurrent see a dermatologist and have it biopsied. Then you will know for certain. ...Read more

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My teen had ANA test but now dr is saying we need a "reflex titer" blood test. What is it and does that mean ANA positive?

Suggestive of auto-: Immune disorder. A high concentration of anti-nuclear antibody is one indicator or auto-immune disease. Titer is one expression for concentration of a particular antibody. See this site for info on ana:
http://www.Nlm.Nih.Gov/medlineplus/ency/article/003535.Htm. ...Read more

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Hx of seronegative RA yet recent labs show high crp/esr, absolute neutrophils and ANA by IFA but w/ no titer. What could that mean without a titer?

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your lab results suggest active on-going inflammation. The titer of ANA is not particularly relevant.
Wish you good health. ...Read more

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Positive ANA IFA screen with reflex is it contagious?

Antibodies: A positive ANA means antibodies which can react with your body's cells. They can form after an infection, but do not indicate anything about the infection which is usually long since gone. There are many, many people whose ANA is positive and very, very few who have actual autoimmune disease. The question to ask is: for what symptoms was the ANA ordered? ...Read more

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Had HSV DNA PCR test with CSF? Negative. Also had HSV 1/2 antibody (IgM), IFA with reflex to Titer, CSF. Negative. Can I still have HSV 1 or 2?

Had HSV DNA PCR test with CSF?  Negative.  Also had HSV 1/2 antibody (IgM), IFA with reflex to Titer, CSF. Negative. Can I still have HSV 1 or 2?

No HSV in CNS: With these tests, you're obviously under a doctor's care, maybe including an infectious diseases specialist or neurologist. They can answer these questions best. But these results effectively rule out HSV infection of your central nervous system. Something else is causing the problem. That said, the HSV IgM test is notoriously unreliable. You probably also had an IgG test, probably negative. ...Read more

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Positive ANA, 1:640 titer, mixed speckled & homgeneous pattern, Neutrophil 63.2%. Thoughts???

You might suffer: from an autoimmune disease, you need additional tests to define what kind. A rheumatologist should see you ...Read more

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ANA pattern was Nucleolar. Can gout or reynauds cause this pattern? Can u be neg & STILL show an Ana pattern? Ana titer was 1:40, Esr of 30.

Whoa: This is a low-titer ANA. I'd ignore the pattern -- there may be lab errors. The sed rate is also not so high as to really be that useful. This is information to note, but we'll need more before we can diagnose / treat CREST, lupus, scleroderma. Gout and common Raynaud's are unrelated to ANA and the vast majority of folks with ANA's at this titer have no illness related to it. ...Read more

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My ANA Hep-2 Titer is >1280 Titer 1 and standard is <80 Titer 1. pattern is Centromere. I have lupus. Just how bad is this result? Common?

Lab tests: Both of these tests may be suggestive of lupus or other autoimmune conditions. However, the lab test are just 1 component of the overall assessment and does not by itself makes the diagnosis of lupus. I recommend seeing a rheumatologist and would be happy to consult if needed. ...Read more

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How worried should I be about a positive ANA diffuse patern titer 1:640. Aches and pains in the morning that diminish with movement. Negative rf...?

How worried should I be about a positive ANA diffuse patern titer 1:640.  Aches and pains in the morning  that diminish with movement.  Negative rf...?

ANA is just a blood : ANA is just a blood test. It all depends on your evaluation. Your rheumatologist will evaluate the bloodwork and the clinical findings and see if there is a specific diagnosis and treatment. ...Read more

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Positive Ana with homogenous pattern titer of 1:160 does this most likely mean I have lupus?

No: This result is weakly positive or even normal in some individuals, positive ANA screen doesn't confirm a disease, it rather complements clinical signs and symptoms, other specific tests, imaging /tissue studies need to be performed in the context of the whole clinical picture. Seek a rheumatologist input if you're in doubt, wish you wellness ...Read more

Theresa Yang Dr. Yang
1 doctor agreed:
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What does a variation in results for ANA blood test in the past all were negative what does it mean if the titer is 1:80 and a speckled pattern ?

Theresa Yang Dr. Yang
1 doctor agreed:

Autoimmune disease: ANA is a marker for autoimmune diseases like lupus and rheumatoid arthritis. A <1:80 titer is low, meaning there is a lower chance of disease. A "speckled pattern" refers to the staining pattern of the markers, which is seen under the microscope. Certain autoimmune diseases produce specific staining patterns. A negative ANA means you do not have that marker of disease. ...Read more

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A positive ANA test 1;320 titer, with a speckled pattern... Does it mean I have an autoimmune disease...

A positive ANA test 1;320 titer, with a speckled pattern... Does it mean I have an autoimmune disease...

Not necessarily: The ANA is a screening test for lupus but is not specific. It can be positive in numerous other diseases and in normal people. It has to be evaluated in the context of the clinical picture and the results of other autoantibody tests. ...Read more

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A positive ANA of 1:80 titer Nucleolar pattern, 36 RF, 22 Sedimentation rate and a 3.0 hsCRP...could this be something?

Nonspecific: This level of ANA is nonspecific but may be indicative of a mild autoimmune disorder but has to be interpreted in context of symptoms and physical findings. Your sed rate is not elevated and if you have no other findings, I doubt you have active inflammatory process going on. A rheumatologist is best qualified to evaluate and advise you about your status. ...Read more

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What do you think? Ana-positive, titer >1:640, speckled/ana titer 2-1:32, ANA pattern 2-homogeneous c3 180.8, rnpab, IgG 1.5, CRP 1.9.

Possible MCTD: The highly positive ANA in a speckled pattern suggests mixed connective tissue disease. Mctd is a close cousin of lupus but usually has a better prognosis. The anti-rnp is usually be elevated in mctd. Interpreting the results of autoantibody studies can confusing. You should discuss these findings with a rheumatologist. ...Read more

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What would cause + ANA nucleolar pattern on 4 tests low titer and now completely negative?

What would cause + ANA nucleolar pattern on 4 tests low titer and now completely negative?

Hard to interpret: Antinuclear antibody tests are famously inconsistent because even when they are done correctly by the lab (and often they are not), the immune system is chaotic and results can vary tremendously from week to week. Ana's, especially at low titer, mean nothing apart from the clinical picture. Try to stay physically fit, and forget about the ANA unless your physician is super-concerned. ...Read more

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Hello doctors, can ulcerative colitis cause a homogeneous pattern on an ANA titer?

Yes: The antinuclear antibody test with the homogeneous pattern can be seen due to some medications and diseases other than lupus and sometimes even in people with no disease at all. ...Read more

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I have had several blood tests done . I have a positive ANA with a titer of 1.1280 speckled pattern 1.128 homogenous pattern 1.1280 CRP was elevated?

Symptoms?: It appears that you likely have an autoimmune disease . Nonetheless the diagnosis of a disease depends on the symptoms and findings. You likely have lupus and I hope you are under the care of a rheumatologist. ...Read more

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Hello My ANA titer test came back as 1:320. Is this very high?. Speckled pattern. I am quite concerned. Than you.

Is positive: This test is positive but only the doctor ordering it can explain to you the significance. ANA tests are notoriouisly positive in people without disease. ...Read more

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What do you suggest if I have been told i tested with a positive ANA homogenous pattern and have a titer of 1:160. What exactly does?

Nothing: This blood test has no value by itself. It is positive in many people with no related disease. It can also be present in lupus and other autoimmune diseases, many infections, cancer, inflammatory vowel disease, and many relatives of people with autoimmune disease. ...Read more

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Ana screen positive, ANA titer 320, rash very often on face, nucleolar pattern. Any significance?

Yes: The pattern is not important but a facial rash and a positive ANA suggest the possibility of some form of lupus. ...Read more

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Can Diltiazem cause a lupus titer of 1:320? I also have positive ana and homogeneous pattern. All other blood test were normal.

Ana positive: Yes it could be related to the meds, Ana us kind of too high, needs to get more specific testing to completely clear the possibility ...Read more

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Ana titer value1:160 for 1and 2 with speckled and homogeneous patterns, RA factor 7, aso less than 100, ESR 29, segs 65.2. Is this lupus?

Positive ANA: Certainly suggestive of lupus. You need to follow with your promsry care physician or a rheumatologist for further tests and treatment. ...Read more