Doctor insights on:
Accurate?: The ANA is fraught with technical difficulties, but it's also critical that you understand how nonspecific a positive ANA is, even at a fairly high titer like 1:160. Perhaps one older person in 4 has a positive ANA and it proves nothing -- the vast majority of healthy. It's only one piece of a diagnostic puzzle. Hope this helps -- if not please repost and let us know exactly what' s up. ...Read more
An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more
Ana direct positive ANA , ifa neg , rnp 2.3, CRP 5.4 ss-b2.7.Diag with lupus connective tissue and sjorgen all at once? Why 2 ANA tests different answ
They can change!: Appears you have mctd with sjogren's like features based on the labs and titers. No lupus marker present! ...Read more
ANA 250 -Indirect Immunofluoresence Assay with both speckled pattern, elevated ESR, rash with lesions on chest, neck,ears,face - LUPUS ?
Talk to doctor: Although these findings are not incompatible with lupus, the lack of joint symptoms points away from the diagnosis. The diagnosis of nearly all diseases should be made by a doctor and not by lab tests alone. ...Read more
How about it?: Up to a quarter of women your age have an ANA (immunofluorescent antibody) at a low titer like yours with a speckled pattern. If there's a question of whether you have lupus or one of its relatives, it's a piece of information to note and file for future reference. A negative ANA would rule several things out. Your result proves nothing positive. Best wishes. ...Read more
Ebv capsid ab IgG 1:580. Positive ccp antibody igg, sed rate, high RDW and mpv on cbc.Liiver alt, AST elevated. Any ideas?
I'm having negative DNA ,Sm and Rnp antibodies, but positive sm/rnp antibody,and high ANA titre speckled,so what is the diagnosis ?
Lupus: These serologies are rather non specific. The speckled ANA is non specific. In Systemic Lupus Erythematosis (SLE) it is usually homogeneous in its staining. Anti-Sm and Anti RNP can be see in mixed connective-tissue diseases and overlaps with SLE, scleroderma and myositis. As often is the case a specific diagnosis cannot be made. You need to see a Rheumatologist. ...Read more
Presented w/ inability to walk, joint/muscle pain, hairloss, positive ana, high ssdna, dsdna, ssa (ro), histone, sed rate, could this be lupus?
Yes: It certainly could be lupus. See a rheumatologist as soon as possible. ...Read more
What is the diffence between ANA direct and ANA ifa? Had test within 24 hours of each other ANA direct was positive ANA ifa negative why would that ha
See below: The ifa or immunoflourescence method is felt to be more accurate. ...Read more
Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?
Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read moreSee 1 more doctor answer
Not always: Unfortunately, there is no single laboratory test that absolutely rules in or out systemic lupus erythematosis (sle). Although a highly positive antinuclear antigen (ANA) is common in sle, diagnosis is based on a careful history, physical exam and laboratory evaluation. ...Read moreSee 1 more doctor answer
What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?
Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more
Past 2 years 3 blood tests ANA direct was normal. Now ANA homogeneous was high 1:320. What is the diff between ANA direct and homogeneous pattern?
I tested positive for the ANA screen, 1:160 titer, speckled pattern. Rheumatoid factor 21, SED rate 22. Does this indicate Rheumatoid arthritis?
Bilirubin direct and indirect fluctuate (indirect 1.2, direct 0.1, total 1.3...Another test: indirect 0.43, direct 0.54, total 0.97), lfts normal.
Might be Gilbert's: A relatively large portion of the population has something called gilbert's, which is completely harmless, and causes elevated indirect bilirubin in times of stress or illness. If you are completely healthy and just have an elevated indirect bilirubin from time to time, it is almost certainly gilbert's. Ask your doctor what he/she thinks. ...Read more