Doctor insights on:
Which tcas is more potent for sciatica pain relief, amitriptyline(or nortriptyline), imipramine(or desipramine)?
TCA: Tca are classic for neuropathic pain - sciatica for example. Any of the ones u mentioned may be quite eefective - and cheap. They are not without side effects - dry mouth, constipation, sedation. Any of the ones u mentioned can be effective. I personally like amytryptilline - 10mg at night - as mentioned all will work. Additionally other meds such as lyrica, (pregabalin) neurontin, Cymbalta are options. ...Read moreSee 1 more doctor answer
Yes: In small doses.Get a more detailed answer ›
See below: Endep (amitriptyline) (amitriptylline) is a medication that is often used for fibromyalgia in certain people. One of the way it helps is that it causes drowsiness and helps people sleep which is a big problem in fibromyalgia. Because of its many side effects, it may not be well tolerated by older people. It should be avoided in people who have heart problems, prostate problems and glaucoma. ...Read moreSee 1 more doctor answer
No: Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults. It has also been found effective for generalized anxiety disorder and is (as of 2007) approved for this use in the european union. It was designed as a more potent successor to gabapentin. ...Read moreSee 2 more doctor answers
Neuropathy: They are different. Often they can used in combination. I tend to reserve Amitriptyline for use at night for patients who are also having trouble with insomnia. Gabapentin must be titrated to minimize side effects. The most common problem i see is practitioners titrating to a high enough dose to get a reduction in pain. ...Read more
Both can be helpful: Both Lyrica (pregabalin) and Gabapentin are used to treat the pain of neuropathy (burning, tingling and sharp, stabbing pain). People respond differently to different medications, so one might work better for one person than another. Some people have side effects to one or the other. If one doesn't work (at what should be an effective dose), it would be worthwhile to try the other. ...Read more
Yes: Cymbalta (duloxetine) is an snri which means it affects both norepinephrine and serotonin. The norepinephrine causes a pseudoantichoinergic effect like caffeine and decongestants and many others that can make it difficult to urinate, esp in older men with prostate problems. It can also help people with bladder frequency. Caffeine and some otc meds are worse. ...Read moreSee 1 more doctor answer
Can taking lyrica (pregabalin) (150 mg) , trazadone (100 mg) and lexa pro (10 mg) cause CNS depression? Also what is it?
Meds and sad mood: None of the medications listed could cause depression individually or together. Depression represents sadness, lack of energy, probable sleep disruption and failure to find pleasure in pleasurable things. It has been liked to chemical imbalance which is often responsive to medications called anti depressants, including the lexapro you mentioned. Lyrica (pregabalin) is often used for pain, trazadone for sleep. ...Read more
Possible: Neurontin (gabapentin) is not a typical sedative tranquilizer, so less chance of depression, but does cause in many drowsiness and dizziness, and far less frequently mild depression. However, may be due to alternative cause, so have your doctor analyze this. Following recent infection, emotional changes may occur, and your pneumonia may be the proximate cause. ...Read more
It depends: Every fibromyalgia patient is different and a medicine that works for one patient may not work for another. Cyclobenzaprine (flexeril) is a muscle relaxant that belongs to a class of drugs called the tricyclic antidepressants. Lyrica (pregabalin) is a seizure medicine that is also used to treat pain. While many patients benefit from these medicines, others don't tolerate them. You will have to try. ...Read moreSee 1 more doctor answer
Yes, for some.: It is generally thought that antidepressants are equally effective in treating depression. Pamelor or nortriptyline, is a tricyclic antidepressants thought to have a "therapeutic window". This refers to a range of blood levels below and above which the medication is not thought as effective. However, the studies were done in inpatient settings and may not relate to outpatient settings. ...Read more