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Doctor insights on: Amitriptyline Interactions

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Dr. Robert Kent
362 doctors shared insights

Elavil (Definition)

Elavil is a tertiary amine tricyclic which is a kind of tricyclic type drug (serotonin-norepinephrine reuptake inhibiting ...Read more


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For severe neuropathy I'm on Cymbalta (duloxetine) 60mg daily. About to add Amitriptyline 50mg daily. Any interactions? Concerned about mood alteration effects.

For severe neuropathy I'm on Cymbalta (duloxetine) 60mg daily. About to add Amitriptyline 50mg daily. Any interactions?  Concerned about mood alteration effects.

Serotonin drugs: taking both medications may increase your risk for serotonin syndrome. Mirtazapine may be a better adjunct to duloxetine. Duloxetine could be raised to a higher dose first. If additional treatment is needed, consider mirtazapine augmentation ...Read more

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Would there be any drug interaction by taking meloxacam and amitriptyline?

Would there be any drug interaction by taking meloxacam  and amitriptyline?

Drug interactions: No drug interactions are listed between Meloxicam & amitriptyline. Remember, however, that Elavil (amitriptyline) alone can have side effects such as sedation, constipation, difficulty urinating, blurred vision. Never mix Elavil with other sedating drugs, especially alcohol. ...Read more

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Are there any dangerous interactions between neurontin, (gabapentin) tramadol, and amitriptyline?

Are there any dangerous interactions between neurontin, (gabapentin) tramadol, and amitriptyline?

Yes: Theoretically this combination may result in mental slowing and other related central nervous system effects. Again, in theory, concomitant use of Amitriptyline and teamadol may cause seizures and so-called serotoninergic syndrome. However, if you take the medications and have no side effects, no other actions but monitoring is required. ...Read more

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My doctors have me on both sertraline (100mg) and amitriptyline (20 mg). Should I be worried about interactions like serotonin syndrome?

I have had patients: on very low dose Amitriptyline with SSRI and none of them had any issues (knocking on wood); however, yes, I do always caution them about potential interactions and advise that they call me immediately should anything occur. ...Read more

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I take levothyroxine 50mcg in morning for hypothyroidism - safe to take 10mg amitriptyline at bed for depression? I've heard there's an interaction.

I take levothyroxine 50mcg in morning for hypothyroidism - safe to take 10mg amitriptyline at bed for depression? I've heard there's an interaction.

Epocrates no interac: Epocrates shows no interactions between levothyroxin and amitriptyline. Even if there were, it would be likely to be insignificant due to the low dose of Amitriptyline that you are taking. No need to worry. Have a good night. ...Read more

Dr. Heidi Fowler
303 doctors shared insights

Endep (Definition)

Endep is a tertiary amine tricyclic which is a kind of tricyclic type drug (serotonin-norepinephrine reuptake inhibiting ...Read more