Doctor insights on:
Alzheimers And Sinemet
Helpful in LBD: I routinely use donepezil effectively in my lewy body disease patients. Although only 40-50% of them actually have cognitive improvements in the here & now, but we suspect it slows the progression of cognitive deterioration anecdotally. Can't comment on personal experience with vascular dementia. ...Read moreSee 4 more doctor answers
No: not without increasing other side effectsGet a more detailed answer ›
What is the difference between Parkinson's drug sinemet and stalevo (carbidopa and levodopa and entacapone)?
COMT inhibitor: Entacaptone is a selective catecholamine-o methyl transferase (comt) inhibitor that increases the bioavailabilty of dopamine. Like Carbidopa in sinemet it does not cross the blood brain barrier. Stalevo (carbidopa and levodopa and entacapone) is a combination of l dopa, Carbidopa and entacaptone. Sinemet is a combination of Carbidopa and l-dopa. ...Read more
High sinemet (carbidopa and levodopa) doses without Parkinson's how do I get off sinemet (carbidopa and levodopa). No doctor at present.?
That depends: upon the reason that you are taking Sinemet, (carbidopa and levodopa) the dose you are taking, and the duration that you have been taking it. Discontinuing medication is usually safer and better tolerated if it is done in a slow stepwise manner. That is my slowly reducing the dosage. ...Read moreSee 1 more doctor answer
What is the protocol for switching a Parkinson’s patient from regular Sinemet (carbidopa and levodopa) to Sinemet (carbidopa and levodopa) CR?
Slow increase: Sinemet (carbidopa and levodopa) CR is a 2x/day treatment vs Sinemet (carbidopa and levodopa) at 4x/day, so to get to twice the daily dose you need to increase dosing slowly over several days, up to a week. I suggest you talk to your doctor, who can nap out a plan to do this safely ...Read more
Is Stalevo (carbidopa and levodopa and entacapone) superior to Sinemet for Parkinson’s? Is one better than the other?
Superiority?: All of the drugs in this class attempt to increase the levels of circulating dopamine. Sinemet is a combination of 2 drugs whereas Stalevo (carbidopa and levodopa and entacapone) is a combination of 3. There is currently an ongoing study at the Mayo Clinic to answer this question - but right now - there isn't any data to demonstrate if one is 'better' than the other. The best treatment is the one that works for you. Hope that helps! ...Read more
May: help symptoms associated with parkinson diseaseGet a more detailed answer ›
Square vs. Rectangle: Dementia is a term for a group of disorders that are characterized by degeneration of certain parts of the brain and cause problems with thinking, comprehension, language and various other cognitive abilities. Alzheimer's dementia is one kind of dementia. Just as all squares are rectangles, but the not all rectangles are squares, alzheimer's is a kind of dementia, but the reverse is not true. ...Read moreSee 1 more doctor answer
How effective is this medicine for treating Parkinson's disease: sinemet (carbidopa and levodopa) (carbidopa-levodopa)?
Early Parkinson's: Would use this for mild and early disease, usually, and it may help tremor, stiffness, and even gait, but likely will benefit for maximum of 2 years. Early usage may prevent later dyskinesias or at least delay need for l-dopa when disease is worse, can use for add on benefit, and may stabilize for a time. ...Read more
Alzheimer, Dementia: Mental status examination including memory impairment, disorientation to time , place, and person, decline in intellectual functioning and impairment of attention and concentration helps in diagnosis of alzheimer, and dementia. At times blood tests and ct scan of brain help in the diagnosis. ...Read moreSee 1 more doctor answer
DBS and medications: DBS is not a replacement for medication and vice versa. Many DBS patients are place on Azilect (rasagiline) before and some after surgery. This drug can block the destruction of Dopamine in the brain. These allows more Dopamine to be available for action. This may induce dyskinesias in some patients but DBS to the GPI can help that side effect ...Read moreSee 1 more doctor answer
In theory, it should: Theoretically, Azilect (rasagiline) (an MAO-B inhibitor) should help with many of the symptoms of Parkinson's for a certain period of time. However, as with all treatments for this disease, they are notoriously unpredictable. I've attached an article which I hope might help. Good luck! http://www.reprintsdesk.com/landing/hf.aspx?h=523154&hr=716110317&a=1&u=0&r=826399194 ...Read more