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Doctor insights on: Alzheimers And Sinemet

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Donepezil effectiveness for vascular and Lewy body dementia?

Donepezil  effectiveness for vascular and Lewy body dementia?

Helpful in LBD: I routinely use donepezil effectively in my lewy body disease patients. Although only 40-50% of them actually have cognitive improvements in the here & now, but we suspect it slows the progression of cognitive deterioration anecdotally. Can't comment on personal experience with vascular dementia. ...Read more

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Dr. Milroy Samuel
46 doctors shared insights

Sinemet (Definition)

Sinemet is a dopamine affecting agent which is a kind of anti-Parkinson's drug ...Read more


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What is the difference between Parkinson's drug sinemet and stalevo (carbidopa and levodopa and entacapone)?

What is the difference between Parkinson's drug sinemet and stalevo (carbidopa and levodopa and entacapone)?

COMT inhibitor: Entacaptone is a selective catecholamine-o methyl transferase (comt) inhibitor that increases the bioavailabilty of dopamine. Like Carbidopa in sinemet it does not cross the blood brain barrier. Stalevo (carbidopa and levodopa and entacapone) is a combination of l dopa, Carbidopa and entacaptone. Sinemet is a combination of Carbidopa and l-dopa. ...Read more

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High sinemet (carbidopa and levodopa) doses without Parkinson's how do I get off sinemet (carbidopa and levodopa). No doctor at present.?

High sinemet (carbidopa and levodopa) doses without Parkinson's how do I get off sinemet (carbidopa and levodopa). No doctor at present.?

That depends: upon the reason that you are taking Sinemet, (carbidopa and levodopa) the dose you are taking, and the duration that you have been taking it. Discontinuing medication is usually safer and better tolerated if it is done in a slow stepwise manner. That is my slowly reducing the dosage. ...Read more

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What is the protocol for switching a Parkinson’s patient from regular Sinemet (carbidopa and levodopa) to Sinemet (carbidopa and levodopa) CR?

What is the protocol for switching a Parkinson’s patient from regular Sinemet (carbidopa and levodopa) to Sinemet (carbidopa and levodopa) CR?

Slow increase: Sinemet (carbidopa and levodopa) CR is a 2x/day treatment vs Sinemet (carbidopa and levodopa) at 4x/day, so to get to twice the daily dose you need to increase dosing slowly over several days, up to a week. I suggest you talk to your doctor, who can nap out a plan to do this safely ...Read more

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Is Stalevo (carbidopa and levodopa and entacapone) superior to Sinemet for Parkinson’s? Is one better than the other?

Is Stalevo (carbidopa and levodopa and entacapone) superior to Sinemet for Parkinson’s? Is one better than the other?

Superiority?: All of the drugs in this class attempt to increase the levels of circulating dopamine. Sinemet is a combination of 2 drugs whereas Stalevo (carbidopa and levodopa and entacapone) is a combination of 3. There is currently an ongoing study at the Mayo Clinic to answer this question - but right now - there isn't any data to demonstrate if one is 'better' than the other. The best treatment is the one that works for you. Hope that helps! ...Read more

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How are alzheimer's disease and dementia different?

How are alzheimer's disease and dementia different?

Square vs. Rectangle: Dementia is a term for a group of disorders that are characterized by degeneration of certain parts of the brain and cause problems with thinking, comprehension, language and various other cognitive abilities. Alzheimer's dementia is one kind of dementia. Just as all squares are rectangles, but the not all rectangles are squares, alzheimer's is a kind of dementia, but the reverse is not true. ...Read more

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How effective is this medicine for treating Parkinson's disease: sinemet (carbidopa and levodopa) (carbidopa-levodopa)?

Probably the best: This medication has never been supplanted, and is still the standard to treat the Parkinsonian issue with dopamine depletion. ...Read more

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Can namenda (memantine) stop progression of alzheimer's?

Can namenda (memantine) stop progression of alzheimer's?

No: It slows down the progression but it does not stop. Unfortunately, at the present time, there are no fda approved medications that have shown to cure or to stop the progression of alzheimer's disease. There are ongoing studies to find ways to cure... ...Read more

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How are Alzheimer's and dementia different?

How are Alzheimer's and dementia different?

Dementia: Alzheimer's is one type of dementia. There are many other types of dementia. ...Read more

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Which symptoms of Parkinson's disease will mirapex (pramipexole) help?

Which symptoms of Parkinson's disease will mirapex (pramipexole) help?

Early Parkinson's: Would use this for mild and early disease, usually, and it may help tremor, stiffness, and even gait, but likely will benefit for maximum of 2 years. Early usage may prevent later dyskinesias or at least delay need for l-dopa when disease is worse, can use for add on benefit, and may stabilize for a time. ...Read more

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How is alzheimer's and dementia diagnosed?

Alzheimer, Dementia: Mental status examination including memory impairment, disorientation to time , place, and person, decline in intellectual functioning and impairment of attention and concentration helps in diagnosis of alzheimer, and dementia. At times blood tests and ct scan of brain help in the diagnosis. ...Read more

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Can exelon, (rivastigmine) aricept, or, namenda treat Lewy body dementia?

Can exelon, (rivastigmine) aricept, or, namenda treat Lewy body dementia?

No: No treatment is yet available for lewy body dementia. However, these might help alleviate some symptoms temporarily. ...Read more

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Is AZILECT (rasagiline) helpful after DBS for Parkinsons?

Is AZILECT (rasagiline) helpful after DBS for Parkinsons?

DBS and medications: DBS is not a replacement for medication and vice versa. Many DBS patients are place on Azilect (rasagiline) before and some after surgery. This drug can block the destruction of Dopamine in the brain. These allows more Dopamine to be available for action. This may induce dyskinesias in some patients but DBS to the GPI can help that side effect ...Read more

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Could namenda (memantine) and trazodone be taken for alzheimers?

Why trazodone? : Namenda (memantine) is a medication approved for treatment of dementia. Sometimes trazodone is given for sleep, but in an older person there may be risk of falling due to sudden drops in blood pressure. ...Read more

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Does Azilect (rasagiline) help to improve speech in Parkinson’s patients?

In theory, it should: Theoretically, Azilect (rasagiline) (an MAO-B inhibitor) should help with many of the symptoms of Parkinson's for a certain period of time. However, as with all treatments for this disease, they are notoriously unpredictable. I've attached an article which I hope might help. Good luck! http://www.reprintsdesk.com/landing/hf.aspx?h=523154&hr=716110317&a=1&u=0&r=826399194 ...Read more

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Aricept (donepezil hcl) useful for dementia Lewy body?

Aricept (donepezil hcl) useful for dementia Lewy body?

Seems to be: As it increases acetylcholine in the brain and that can improve attention deficits and cognitive fluctuations. ...Read more

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Dr. Stephen Scholand
40 doctors shared insights

Carbidopa And Levodopa (Definition)

Carbidopa|levodopa is an ear drop which is a kind of ...Read more