Top
30
Doctor insights on: Alteplase Medication

Share
Dr. Arnold Malerman
3 Doctors shared insights

Cathflo Activase (Definition)

Cathflo Activase is a clot buster which is a kind of ...Read more


3

3
Why use alteplase drug in treatment. Of myocardial infarction?

Why use alteplase drug in treatment. Of myocardial infarction?

To stop it!: It treated soon enough, a clot-based coronary artery obstruction can be dissolve with this medication before signifcant to the heart muscle can occur. ...Read more

5

5
Who should not use Alteplase injections?

Alteplase injections: CONTRAINDICATIONS: Active internal bleeding. Recent intracranial or intraspinal surgery or serious head trauma. Intracranial conditions that may increase the risk of bleeding. Bleeding diathesis. Current severe uncontrolled hypertension. Acute Ischemic Stroke • Current intracranial hemorrhage. Subarachnoid hemorrhage. Acute Myocardial Infarction.or Pulmonary Embolism
recent stroke. See: ...Read more

6

6
What should be monitored before administering the tpa (alteplase)?

What should be monitored before administering the tpa (alteplase)?

Complicated: You need to check it with your physician since it depends on many parameters, but generally speaking: head ct, blood pressure, age, time onset of stroke, coagulant estate and use of anticoagulation, history of previous stroke, bleeding and recent surgeries.... ...Read more

7

7
How effective are Alteplase injections for treating stroke?

FDA approved for AIS: AIS = acute ischemic stroke. Think FAST (http://goo. Gl/I9dyo2) = Face droopy, Arms (or legs) weak, Speech difficult, Time to call 911. We have less than 3hrs after symptom onset. Check out http://www. Drugs. Com/cdi/alteplase. Html & http://www. Activase. Com/iscstroke (yes, I know it's Big Pharma but it's informative, and no, I have no relation). ...Read more

10

10
What is tpa, (alteplase) and why is it important in stroke?

What is tpa, (alteplase) and why is it important in stroke?

TPA (alteplase): Tpa (alteplase) or tissue plasminogen activator is a subtance that is used to break up clots that form in the body. It has been used to stop heart attacks, strokes or clots that form in the arms or legs. It has even been used to dissolve clots in the lungs with some success. ...Read more

11

11
What % of ischemic MCA stroke patients benefit from tpa (alteplase)?

What % of ischemic MCA stroke patients benefit from tpa (alteplase)?

Depends: This is a complex question. It depends on what percent of is already showing signs of infarction (dead brain) rather than just ischemia (brain at risk).... When we see > 1/3 of territory abnormal on initial ct scan, it is a contraindication for tpa (alteplase).
It also depends on how long the symptoms have been occurring.
But to answer your question, theoretically all could potentially benefit. ...Read more

13

13
What is the age limit for being given tpa (alteplase)?

What is the age limit for being given tpa (alteplase)?

Gradient: The older one gets, the greater the risk of intracerebral hemorrhage. Especially after age 75 risk escalates. Then this turns on risk-benefit estimation. ...Read more

14

14
What is the age limit for being given tpa (alteplase)?

Used to be rigid: Used to be arbitrary age which I believe was 75 and now is individualized. ...Read more

15

15
Why don't stroke patients get tpa (alteplase) therapy?

They can: If having a stroke one can receive intravenous tpa (alteplase) up to 3 hours once symptoms begin and up to 4.5 hours in certain cases. After this intra. ...Read more

16

16
Could you tell me what happens if a person who is not actually having a stroke is given tpa (alteplase)?

Increased bleed risk: Tissue plasminogen activator, or tpa, (alteplase) "dissolves" clots, so the main risk from it's administration is an increased risk of bleeding. One way to reduce the risk is to have strict rules on who it is administered to, based on many factors including time since symptoms began. Another is to administer it right where it is needed, near the location of the artery which contains the clot. ...Read more

18

18
Tpa (alteplase) fail & they wait to do surgery until family is located. Too late by then for surgery. Er dr couldn't do surgery cuz he didn't have informed consent.?

Tpa (alteplase) fail & they wait to do surgery until family is located. Too late by then for surgery. Er dr couldn't do surgery cuz he didn't have informed consent.?

Not nessecarily: It depends on the situation and the emergent nature of the procedure needed. It is always preferred, to have informed consent prior to doing anything, but under certain situations/emergencies a life saving procedure can be performed even if informed concent is not possible. ...Read more

19

19
Docs, could a patient be given tpa (alteplase) when on antiplatelet therapy?

Yes: TPA (alteplase) is not contraindicated with people taking aspirin, NSAIDs or antiplatelet drugs (dipyridamole, ticlopidine, clopidogrel). TPA (alteplase) is a contraindicated in people on warfarin whose INR is greater than 1.7. Use of low molecular weight heparin in the past 24 hours is also a contraindication. ...Read more

20

20
How much time to hold tpa (alteplase) if a patient had stroke and is on dabigatran therapy?

No TPA (alteplase): Dabigatran is an absolute contraindication to TPA (alteplase) use. The stroke patient in question is not a candidate for TPA (alteplase). ...Read more

21

21
Is tpa (alteplase) available to stroke patients in trinidad and how does it differ from aspirin?

Powerful Clot buster: Tpa (alteplase) is likely available in trinidad to help treat strokes (now sure, but likely at certain hospitals). It is a very powerful medication that helps to break up blood clots. It can be quite dangerous though, can cause serious bleeding and should only be used in certain life-treatening situations. Aspirin can also cause bleeding, but works differently from tpa (alteplase) in that it prevents clot from forming. ...Read more

23

23
In icu. Left sided numbness pain weakness. Tpa (alteplase).All tests so far negative. All doctors no clue what's going on. Think stroke not sure. Any ideas?

In icu. Left sided numbness pain weakness. Tpa (alteplase).All tests so far negative. All doctors no clue what's going on. Think stroke not sure. Any ideas?

? migraine: An entity called hemiplegic migraine could present this way, and typically the process is reversible. Small stroke might be tough to see on certain types of mri's and a perfusion/diffusion approach might reveal. A series of tests to confirm your etiology might be useful. Neurology involvement is key here. ...Read more

25

25
My dad had an ischemic stroke on Thurs. & was given TPA (alteplase). He has a "minimal" bleed on his brain. Does this heal itself, and what is the recovery time?

Yes, it heals: There is always healing as long as we are alive. The extent of healing and the recovery time depends mainly on characteristics of the patient and degree of injury. If your father is young and healthy or stroke is minor, relatively short recovery time. If old and sick or stroke is major, longer recovery. The blood will get slowly absorbed over weeks but this has very little to do with recovery. ...Read more

26

26
My dad suffered an ischemic stroke on thursday. He Was given TPA (alteplase). He now has a "minimal" bleed on his brain. Could this get worse once he is discharge?

My dad suffered an ischemic stroke on thursday. He Was given TPA (alteplase). He now has a "minimal" bleed on his brain. Could this get worse once he is discharge?

Not likely: Bleeding in this setting usually occurs 4-12 hours after t-PA administration. If your father got t-PA, then there is a neurologist experienced in acute stroke treatment at that hospital. He/she is the best person to ask for information specific to your father. Ask to see the actual scan images and to have them explained to you. In radiology, 1 picture really is worth 1000 words. ...Read more

27

27
My husband is hospitalized for dvt. Should he ask for inferior vena cava filter even if he doesn't undergo tpa (alteplase) treatment? (unsure when clot formed.)

My husband is hospitalized for dvt. Should he ask for inferior vena cava filter even if he doesn't undergo tpa (alteplase) treatment? (unsure when clot formed.)

No: The indication for ivc filter placement in a patient with an acute DVT is usually related to a contraindication of the patient to be anticoagulated. If your husband can be anticoagulated then ther is no reason for him to have a filter. ...Read more

28

28
How effective is t-pa for a 90 year old suffering a stroke?

How effective is t-pa for a 90 year old suffering a stroke?

Might help: When thromboplastin activator first appeared it was felt dangerous for elderly pts, and only safe if used very early. All of this is now modified and it may be both safe and effective in older pts if additional risk factors are not present. However, still most effective if used as early as possible. ...Read more

29

29
How effective would t-pa be for a 95 year old with a stroke?

Opinion: You may find a variable amount of opinions but from a neurosurgeons perspective, the risk is too high to give tpa (alteplase) to a 95 year old with a stroke. Someone needs to have a frank discussion with the family regarding proper treatment for patients of a certain age. The tpa (alteplase) may work great, but the risks of hemorrhage or other life threatening complications is high. ...Read more

30

30
Please explain plasminogen activator.?

Clot Buster: Tissue plasminogen activator (tpa (alteplase)) is a chemical that triggers rapid breakdown of blood clots. It is used in stroke patients in an attempt to restore bloodflow to the brain before cells die, but the risk of bleeding makes it safe to use only in very specific circumstances. The most common reason for not qualifying for tpa (alteplase) is not getting to the er quickly enough- don't wait! Time is brain! ...Read more

Dr. Tanya Russo
12 Doctors shared insights

Alteplase (Definition)

Alteplase is a clot buster which is a kind of ...Read more


Dr. Walter Husar
3 Doctors shared insights

Activase (Definition)

Activase is a clot buster which is a kind of ...Read more