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2 years ago all tests say I didn't have a stroke. Administered tpa (alteplase) and improved. Why did I respond to a drug for something tests say I didn't have?
Alteplase injections: CONTRAINDICATIONS: Active internal bleeding. Recent intracranial or intraspinal surgery or serious head trauma. Intracranial conditions that may increase the risk of bleeding. Bleeding diathesis. Current severe uncontrolled hypertension. Acute Ischemic Stroke • Current intracranial hemorrhage. Subarachnoid hemorrhage. Acute Myocardial Infarction.or Pulmonary Embolism recent stroke. See: ...Read more
FDA approved for AIS: AIS = acute ischemic stroke. Think FAST (http://goo.gl/I9dyo2) = Face droopy, Arms (or legs) weak, Speech difficult, Time to call 911. We have less than 3hrs after symptom onset. Check out http://www.drugs.com/cdi/alteplase.html & http://www.activase.com/iscstroke (yes, I know it's Big Pharma but it's informative, and no, I have no relation). ...Read more
Alteplase: Yes you do.Get a more detailed answer ›
TPA (alteplase): Tpa (alteplase) or tissue plasminogen activator is a subtance that is used to break up clots that form in the body. It has been used to stop heart attacks, strokes or clots that form in the arms or legs. It has even been used to dissolve clots in the lungs with some success. ...Read moreSee 2 more doctor answers
Depends: This is a complex question. It depends on what percent of is already showing signs of infarction (dead brain) rather than just ischemia (brain at risk).... When we see > 1/3 of territory abnormal on initial ct scan, it is a contraindication for tpa (alteplase). It also depends on how long the symptoms have been occurring. But to answer your question, theoretically all could potentially benefit. ...Read more
Used to be rigid: Used to be arbitrary age which i believe was 75 and now is individualized. ...Read more
Could you tell me what happens if a person who is not actually having a stroke is given tpa (alteplase)?
Increased bleed risk: Tissue plasminogen activator, or tpa, (alteplase) "dissolves" clots, so the main risk from it's administration is an increased risk of bleeding. One way to reduce the risk is to have strict rules on who it is administered to, based on many factors including time since symptoms began. Another is to administer it right where it is needed, near the location of the artery which contains the clot. ...Read more
Tpa (alteplase) fail & they wait to do surgery until family is located. Too late by then for surgery. Er dr couldnt do surgery cuz he didn't have informed consent.?
Not nessecarily: It depends on the situation and the emergent nature of the procedure needed. It is always preferred, to have informed consent prior to doing anything, but under certain situations/emergencies a life saving procedure can be performed even if informed concent is not possible. ...Read moreSee 1 more doctor answer
Yes: TPA (alteplase) is not contraindicated with people taking aspirin, NSAIDs or antiplatelet drugs (dipyridamole, ticlopidine, clopidogrel). TPA (alteplase) is a contraindicated in people on warfarin whose INR is greater than 1.7. Use of low molecular weight heparin in the past 24 hours is also a contraindication. ...Read more