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2 years ago all tests say I didn't have a stroke. Administered tpa (alteplase) and improved. Why did I respond to a drug for something tests say I didn't have?
Question: So if you didn't have a stroke what improved when you got the TPA (alteplase)? ...Read more
CONTRAINDICATIONS: Active internal bleeding. Recent intracranial or intraspinal surgery or serious head trauma. Intracranial conditions that may increase the risk of bleeding. Bleeding diathesis. Current severe uncontrolled hypertension. Acute Ischemic Stroke • Current intracranial hemorrhage. Subarachnoid hemorrhage. Acute Myocardial Infarction.or Pulmonary Embolism
recent stroke. See: ...Read more
FDA approved for AIS: AIS = acute ischemic stroke. Think FAST (http://goo. Gl/I9dyo2) = Face droopy, Arms (or legs) weak, Speech difficult, Time to call 911. We have less than 3hrs after symptom onset. Check out http://www. Drugs. Com/cdi/alteplase. Html & http://www. Activase. Com/iscstroke (yes, I know it's Big Pharma but it's informative, and no, I have no relation). ...Read more
Alteplase: Yes you do.Get a more detailed answer ›
TPA (alteplase): Tpa (alteplase) or tissue plasminogen activator is a subtance that is used to break up clots that form in the body. It has been used to stop heart attacks, strokes or clots that form in the arms or legs. It has even been used to dissolve clots in the lungs with some success. ...Read more
This is a complex question. It depends on what percent of is already showing signs of infarction (dead brain) rather than just ischemia (brain at risk).... When we see > 1/3 of territory abnormal on initial ct scan, it is a contraindication for tpa (alteplase).
It also depends on how long the symptoms have been occurring.
But to answer your question, theoretically all could potentially benefit. ...Read more
Gradient: The older one gets, the greater the risk of intracerebral hemorrhage. Especially after age 75 risk escalates. Then this turns on risk-benefit estimation. ...Read more
Used to be rigid: Used to be arbitrary age which I believe was 75 and now is individualized. ...Read more
They can: If having a stroke one can receive intravenous tpa (alteplase) up to 3 hours once symptoms begin and up to 4.5 hours in certain cases. After this intra. ...Read more
Could you tell me what happens if a person who is not actually having a stroke is given tpa (alteplase)?
Increased bleed risk: Tissue plasminogen activator, or tpa, (alteplase) "dissolves" clots, so the main risk from it's administration is an increased risk of bleeding. One way to reduce the risk is to have strict rules on who it is administered to, based on many factors including time since symptoms began. Another is to administer it right where it is needed, near the location of the artery which contains the clot. ...Read more
Tpa (alteplase) fail & they wait to do surgery until family is located. Too late by then for surgery. Er dr couldn't do surgery cuz he didn't have informed consent.?
Not nessecarily: It depends on the situation and the emergent nature of the procedure needed. It is always preferred, to have informed consent prior to doing anything, but under certain situations/emergencies a life saving procedure can be performed even if informed concent is not possible. ...Read more
Yes: TPA (alteplase) is not contraindicated with people taking aspirin, NSAIDs or antiplatelet drugs (dipyridamole, ticlopidine, clopidogrel). TPA (alteplase) is a contraindicated in people on warfarin whose INR is greater than 1.7. Use of low molecular weight heparin in the past 24 hours is also a contraindication. ...Read more
No TPA (alteplase): Dabigatran is an absolute contraindication to TPA (alteplase) use. The stroke patient in question is not a candidate for TPA (alteplase). ...Read more
Powerful Clot buster: Tpa (alteplase) is likely available in trinidad to help treat strokes (now sure, but likely at certain hospitals). It is a very powerful medication that helps to break up blood clots. It can be quite dangerous though, can cause serious bleeding and should only be used in certain life-treatening situations. Aspirin can also cause bleeding, but works differently from tpa (alteplase) in that it prevents clot from forming. ...Read more
In icu. Left sided numbness pain weakness. Tpa (alteplase).All tests so far negative. All doctors no clue what's going on. Think stroke not sure. Any ideas?
? migraine: An entity called hemiplegic migraine could present this way, and typically the process is reversible. Small stroke might be tough to see on certain types of mri's and a perfusion/diffusion approach might reveal. A series of tests to confirm your etiology might be useful. Neurology involvement is key here. ...Read more
What happens if a patient is on clopidogrel/brilinta/effient etc and have a stroke, can they receive tpa (alteplase)?
MAY BE: NOT IF YOU HAVE A HEMORRHAGIC STROKE. ...Read more
My dad had an ischemic stroke on Thurs. & was given TPA (alteplase). He has a "minimal" bleed on his brain. Does this heal itself, and what is the recovery time?
Yes, it heals: There is always healing as long as we are alive. The extent of healing and the recovery time depends mainly on characteristics of the patient and degree of injury. If your father is young and healthy or stroke is minor, relatively short recovery time. If old and sick or stroke is major, longer recovery. The blood will get slowly absorbed over weeks but this has very little to do with recovery. ...Read more
My dad suffered an ischemic stroke on thursday. He Was given TPA (alteplase). He now has a "minimal" bleed on his brain. Could this get worse once he is discharge?
Not likely: Bleeding in this setting usually occurs 4-12 hours after t-PA administration. If your father got t-PA, then there is a neurologist experienced in acute stroke treatment at that hospital. He/she is the best person to ask for information specific to your father. Ask to see the actual scan images and to have them explained to you. In radiology, 1 picture really is worth 1000 words. ...Read more
My husband is hospitalized for dvt. Should he ask for inferior vena cava filter even if he doesn't undergo tpa (alteplase) treatment? (unsure when clot formed.)
No: The indication for ivc filter placement in a patient with an acute DVT is usually related to a contraindication of the patient to be anticoagulated. If your husband can be anticoagulated then ther is no reason for him to have a filter. ...Read more
Might help: When thromboplastin activator first appeared it was felt dangerous for elderly pts, and only safe if used very early. All of this is now modified and it may be both safe and effective in older pts if additional risk factors are not present. However, still most effective if used as early as possible. ...Read more
Opinion: You may find a variable amount of opinions but from a neurosurgeons perspective, the risk is too high to give tpa (alteplase) to a 95 year old with a stroke. Someone needs to have a frank discussion with the family regarding proper treatment for patients of a certain age. The tpa (alteplase) may work great, but the risks of hemorrhage or other life threatening complications is high. ...Read more
Clot Buster: Tissue plasminogen activator (tpa (alteplase)) is a chemical that triggers rapid breakdown of blood clots. It is used in stroke patients in an attempt to restore bloodflow to the brain before cells die, but the risk of bleeding makes it safe to use only in very specific circumstances. The most common reason for not qualifying for tpa (alteplase) is not getting to the er quickly enough- don't wait! Time is brain! ...Read more