Doctor insights on:
Enzyme : Alpha-1-antitrypsin is an enzyme that turns off another enzyme that breaks down elastic tissue. Deficiency can result in severe and premature emphysema especially when combined with smoking or dust exposure. Liver damage canals be a consequence. There are simple tests to check your level. It is an inherited disease and runs in some families. ...Read more
Antitrypsin: Alpha-1 antitrypsin is a normal blood protein that keeps some of the products of your neutrophils from harming your tissues more than they need to. If you're seriously deficient, you'll develop emphysema in midlife, and at some time in your life may develop serious liver function problems. One serious pitfall is assaying the levels during concurrent illness; they may be misleading. Good luck. ...Read more
Depends!: Listed as an uncommon side-effect, but usually not. Coming off them is more likely, since the drugs decrease sympathetic nervous system activity. So if you mean "rebound" in stopping, yes! ...Read more
Simply healthy: Hi AMonroe, The good news is that you don't any specific diet restrictions. Aim to stay in a healthy weight range with a BMI of 20-25. Choose fresh foods, eat plenty of vegetables and moderate amounts of fruits. The majority of your nutrient breakdown should be protein and carbs. Fats should be more omega-3s if possible. Stay active, sleep well. Hope this helps. ...Read more
Alpha-1 is MZ 107.9mg/dl(20.7uM)
Mildly Deficient , should begin infusion or not? It is once a week /lifetime
SPEP test: High Alapha1 .27 (.10-.20) High Alpha1% 3.6% (1.4-2.7%) High Gama 1.23 (.6-.1.2) Low Beta 5.9% (6-9%) and IFE tested positive. Cancer?
Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, none of the information you provided suggests cancer. Ife was positive for what? For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. Get HPV vaccine. ...Read more
Chemo: Yes.Get a more detailed answer ›
Liver or lung?: most good pulmonologists and hepatologists would certainly be well versed in what is admittedly a rare disease. If you're not finding it to be the case near where you are, i'd call the nearest academic medical center. If your issues are even more unique, they could also refer you to the most specialized centers across the country. best of luck. ...Read more
In an spep why is reg albumin ok and the % low? Alpha 1 % high and just beta high? Inflammatory ? The% confuses me.
Doez Prazosin cross the BBB and work in the CNS? Ive read conflicting things on pubmed and elsewhere. Does any alpha-1 blocker cross the BBB?
You must be reading: about its use as it treats nightmares in the brain. So yes, it clearly crosses the BBB and clearly WORKS. I treat many people with PTSD and nightmares from war vets to civilians, rape victims, assault, other abuse victims who have terrible nightmares and it practically clears everything up inside of 1 week or 2. Problems are lowered blood pressure, allergic reactions, and, first dose syncope. ...Read more
Diagnosis of AAT def: Alpha-1-antitrypsin is a protease inhibitor of the enzyme elastase. Deficiency can result in disease of the lung, liver, and skin. The serum level is quantified in the diagnosis of aat deficiency. If the aat serum level is greater than 80 mg/dl, it is unlikely that the patient has clinically significant aat deficiency. ...Read more
No: It may be mild or severe. You're born with it, you are likely to become short of breath in middle age (hopefully you are a non-smoker), and the liver disease may come on at any time in your life, or never. ...Read more
AAT deficiency: Measurement of alpha-1-antitrypsin serum concentration is used to determine if a patient has the inherited disorder aat deficiency. If the aat serum level is greater than 80 mg/dl, it is unlikely that the patient has clinically significant aat deficiency. ...Read moreSee 1 more doctor answer
Both: Alpha blockers relax the smooth muscle component of the prostate (as opposed to the glandular part). They also relax the INTERNAL urinary sphincter at the neck of the bladder.This is why retrograde ejaculation(the ejaculate goes into the bladder instead of coming out) can occur. They do not relax the EXTERNAL sphincter(below the prostate) which controls urine voluntarily. ...Read more
HI - just found out I'm Alpha-1 MZ, level is 128 but I have nearly every symptom of COPD - test came back ok. What are treatments?
Inhalers: Regardless of your genetic predisposition, if you have been diagnosed with COPD, the mainstay of treatment is inhalers. Diagnosis is made by PFTs, pulmonary function tests, where they measure how much & how fast you breathe through a tube. Treatment mainly cnsists of steroids inhalers & short-acting inhalers like Albuterol. Long-acting inhalers are used for more severe disease. Good luck, TTYD ...Read more
Can being a alpha-1 mz carrier be the cause why my my daughter coughs to the point of vomiting almost every night? How do I help her coughing?
Post tussive emesis: Is more commonly found with pertussis, but some people have a stronger gag reflex. What exactly is your daughters full diagnosis? Night cough is common with asthma, and vomiting up a stomach full of snot in the morning is common with post nasal drip in kids too young to blow their nose. ...Read more
What does " ALPHA-1-ANTITRYPSIN " mean?Component Standard Range Your Value 90 - 200 mg 218
why is mine elevated?
Alpha-1: Alpha-1-antitrypsin is a protein produced by the liver which helps to protect the liver and lungs from damage. Approximately 1 in 2,500 people have a deficiency (hereditary) which puts them at higher risk for early lung (COPD) and liver disease (cirrhosis, cancer). This deficiency can be detected by a blood test. ...Read moreSee 1 more doctor answer
More data needed: Marketed as zadaxin, first immino boosting synthetic peptide, shown in animals to boost immunity, which lacks thymus.. On humans has promising results , used in hepatitis b & c with or with out interferon. Under intense investigation as a adjuvant in varieties of cancers( breast , melanoma, lung kidney etc )plays complex immuno modulation, t cell maturation , prevent apoptosis ( cell death ). ...Read more
Inflammation: Serum protein electrophoresis is a test that examines specific proteins in the blood, serum Albumin and alpha-1, alpha-2, beta, and gamma globulins. In the alpha-1 zone, alpha-1 antitrypsin (aat) is the major protein, which is involved in neutralizing enzymes secreted by inflammatory cells. Aat is increased in acute inflammation. ...Read more