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Doctor insights on: Alpha Thalassemia

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What are the long-term consequences of alpha thalassemia?

What are the long-term consequences of alpha thalassemia?

None to severe/fatal: Alpha thalassemia signs and symptoms: silent carriers have no signs/symptoms (and live a normal life); Alpha trait has mild anemia (and generally live a normal life); HGB h (moderate) may have weakness, pallor, less growth, and need some transfusions; bart's disease (severe) is usually fatal before birth. ...Read more

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Dr. Warren Foster
30 doctors shared insights

Hemoglobin H Disease (Definition)

Hemoglobin H disease (alpha thalassemia) is a blood disease where one of the molecules that helps carry oxygen in the blood cell is missing. This causes a ...Read more


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What are the common symptoms of alpha thalassemia?

What are the common symptoms of alpha thalassemia?

None to severe/fatal: Alpha thalassemia signs and symptoms: silent carriers have no signs/symptoms; Alpha trait has mild anemia; HGB h (moderate) may have weakness, pallor, less growth, and need some transfusions; bart's disease (severe) is usually fatal before birth. ...Read more

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What is the diagnostic test for alpha thalassemia?

Blood tests: Alpha thalassemia is diagnosed by blood tests: routine blood counts, hemoglobin electrophoresis to find out the types of hemoglobin one has in one's blood, and dna analysis to try to see if certain mutations are present. ...Read more

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TTC&RE done several blood tests.I am negative but inconclusive to alpha thalassemia.How?DH tested for Hgb electrophoresis.Why?Is it serious?what next?

TTC&RE done several blood tests.I am negative but inconclusive to alpha thalassemia.How?DH tested for Hgb electrophoresis.Why?Is it serious?what next?

Genetics consult: If you are trying to have a baby or will do so in the future, tis important to know what the chances are for the baby to have the disease. If you are both carriers, then there is a higher risk for the baby to have the disease. You said he was tested but never said if he is positive for carrier state or does he have it? Talk to a geneticist, there's always one associated with children's hosp ...Read more

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Can you donate blood if you have alpha thalassemia minor?

Possible: It mainly depends on the status of anemia at the time when the individual with Alpha thalassemia minor present at donation (hemoglobin higher than 12.5 or hematocrit at 38 or higher). You also need to comply to other criteria as qualified blood donor which vary between states in the us. ...Read more

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Does alpha thalassemia causes leukemia?

Does alpha thalassemia causes leukemia?

No: Alpha and beta thalassemia have not been reported to cause leukemia, which is cancer of the white blood cells. There is a study of beta thal. Major & intermedia patients in iran, where researchers found 5 leukemia cases in about 4, 600 patients. That is a higher rate of leukemia than in the general population there, but details were unavailable as to what other factors were present in the patients. ...Read more

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Alpha thalassemia, what does it mean and what are the implications?

Inherited defect: Our regular hemoglobin is composed of Alpha and beta chains that come together to form working hemaglobin. Alpha thalassemia trait occurs when a person inherits a defective Alpha chain gene from one parent & a normal Alpha chain gene from the other. This causes some reduction in Alpha chain production with resulting mild anemia. ...Read more

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Is there a treatment available for people with sickle cell trait and alpha thalassemia?

Is there a treatment available for people with sickle cell trait and alpha thalassemia?

Yes: Hematologists (blood specialists) evaluate persons with both sickle cell trait and Alpha thalassemia disease. The sickling should not be a problem, because the person is only sickle trait, and Alpha thal. Mutations seem to lessen the tendency of blood cells to sickle from the sickle cell mutation. Persons with both sickle trait and Alpha thal. Trait probably won't have symptoms needing treatment. ...Read more

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Emily Lu Dr. Lu
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Who is at risk of getting alpha thalassemia?

Emily Lu Dr. Lu
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Family history: Thalassemia is a genetic disease of the hemoglobin molecule and so only occurs through inheritance. A mutation in this gene is especially prevalent in persons of african, asian, middle eastern or mediterranean descent. Individuals with only one mutation of the gene will be asymptomatic, so genetic screening is necessary to precisely determine risk. ...Read more

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Dr. Michael Engel
270 doctors shared insights

Thalassemia (Definition)

Thalassemia is sever anemia,it ...Read more