Doctor insights on:
Alpha One Trypsin Deficiency
Is it safe to take a nutritional supplement that has trypsin and chemotrypsin if you have an alpha-1 antitrypsin deficiency?
Yes but not helpful: Trypsin ; chemotrypsin being proteins get digested and broken down in to individual Amino Acids before being absorbed from the gut. So in terms of safety, there are no concerns. However, i don't think they have any value of health benefit as nutritional supplements. ...Read more
Trypsin is an enzyme made and secreted by the pancreas to help breakdown/digest the profteins you consume. It is actually secreted in an inactive-form called trypsinogen; once in the small instestine area, it is converted into trypsin which then breaks down the protein down to aminoacids to ready for absorption into your body. Trypsin deficiency is quite serious. ...Read more
My dad is suddenly having rashes all over his body and he took alpha chemo trypsin for 4 days what could it be?
Stop the drug : First of- is stop the Alpha chemo trypsin or whatever new medication that he takes. Second, call his primary care doctor and go to see your doctor for further evaluation and treatment. Drug induced rash is very common and sometimes, not only annoying and that could be lethal in a few condition- like in steven johnson syndome etc. ...Read more
Can you tell me the effects of alpha one antitrypsin deficiency and is it safe for people with it to take drugs?
Emphysema: Individuals with anti Alpha 1 deficiency are more prone to the environmental oxidative factors such as polution, smoking, etc therefore they get emphysema eventually especially if they smoke. Logically these individuals could get lung/liver damage if take medications which are inceasing oxidative status. Shahzeidi, md. ...Read more
Chemo: Yes.Get a more detailed answer ›
Genetic disease: It's quite variable in severity. The lack of the helpful antitrypsin protein in the blood prevents the neutralization of enzymes from white cells that tend to decrease the elasticity of the lungs. The enzyme itself accumulates in the liver which can't get it into the circulation and this can ruin the liver. This can happen at any age and no one knows why it varies so much; or the liver may be fine. ...Read more
Blood test: Blood, more accurately serum, is examined for levels of Alpha 1 at. Electophoresis of serum also reveals deficiency and a detailed electrophoresis, iso-electric focusing, provides details of the abnormal protein. Dna also can be tested to ascertain the abnormality in the gene. ...Read more
Genetic, familial: Genetic abnormality that can run in families, associated with emphysema, even without the usual triggers like tobacco use, and cirrhosis of the liver, even in the absence of triggers like chronic infection, alcohol use. Can cause problems in children and/or in adults. Can be tested for, can be rx'd. ...Read more
Emphysema: Aat deficiency affects primarily the lungs, leading to copd, particularly a panacinar emphysema. Symptoms are variable, but usually involve shortness of breath on exertion, cough, or wheezing. It can also affect the liver, causing chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Necrotizing panniculitis is a rare clinical manifestation involving the skin. ...Read more
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