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Doctor insights on: Alpha Globin Gene Sequencing

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Does alpha thalassemia trait have gene therapy available?

Does alpha thalassemia trait have gene therapy available?

No: Alpha thalassemia trait only causes mild anemia, and the person usually has no symptoms. Gene therapy is not available and would not be needed. ...Read more

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Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


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Can you tell me how is the gene for alpha thalassemia an adaptive trait?

Can you tell me how is the gene for alpha thalassemia an adaptive trait?

Adaptive?: Not certain what you mean. Alpha Thal trait is a genetic--hereditary finding, which was shared with you by either your Mom or Dad. It is not adaptive as sickle cell trai/disease to help prevent malaria, to my knowledge. ...Read more

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Can you tell me why PCR and DNA sequencing provided no results for brent's pathogen.?

Can you tell me why PCR and DNA sequencing provided no results for brent's pathogen.?

Homework: This is the last line from a long homework problem that's already all over other answer boards. It's not appropriate to bring it here, and without the rest of the problem, we can't answer it anyway. ...Read more

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Does alpha thalassemia trait have gene therapy available?

No: Alpha thalassemia trait only causes mild anemia, and the person usually has no symptoms. Gene therapy is not available and would not be needed. ...Read more

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What is the difference in gene sequencing tests vs gene deletion/duplication tests? Should one type of genetic test be done before the other?

What is the difference in gene sequencing tests vs gene deletion/duplication tests?  Should one type of genetic test be done before the other?

Depends: Sequencing is like reading war and peace letter by letter, and deletion/duplication testing is like seeing if a chapter is completely missing or present as an extra copy. Which first? Depends on the condition. For duchenne muscular dystrophy, look for deletions first. For brca, sequence first. Your clinical geneticist can discuss the strategy with you. ...Read more

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My brother has alpha 1 antiitrypsin gene with his liver affected, Awaiting my own results ..what are my odds of having it? Should my kids be tested?

My brother has alpha 1 antiitrypsin gene with his liver affected,  Awaiting my own results ..what are my odds of having it?  Should my kids be tested?

Variable: Alpha 1 antitrypsin disease results (usually) when two unaffected carriers donate their recessive gene to the offspring. With 2 abnormal genes, the medical condition can be expressed. If you share the same parents, you have 3 potential outcomes. Normal,with two normal genes; a carrier with one normal and one abnormal: or you have it but don't know it(unlikely). 2:1 carrier than normal ...Read more

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Can you tell me how is the gene for alpha thalassemia an adaptive trait?

Adaptive?: Not certain what you mean. Alpha Thal trait is a genetic--hereditary finding, which was shared with you by either your Mom or Dad. It is not adaptive as sickle cell trai/disease to help prevent malaria, to my knowledge. ...Read more

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How to differentiate between alpha thalassaemia trait and hb h disease without a genetic test?

Electrophoresis, but: Levels of hemoglobin h and hemoglobin barts should make the distinction straightforward though there may be modifying genes that could make interpretation. The real question is the implications in planning your family and for this perhaps you would like to have genetic testing done. Any hematologist would probably enjoy helping you out. Good luck. ...Read more

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How much DNA is needed for nanopore sequencing?

How much DNA is needed for nanopore sequencing?

A future scientist: How much do you think is required? a single strand? A single molecule? I encourage you to find the answer. Best of wishes to your future endeavors. ...Read more

Gene (Definition)

A hereditary unit consisting of a sequence of dna that occupies a specific location on a chromosome and determines a particular characteristic in an organism. Genes undergo mutation when their ...Read more


Dna (Definition)

Dna are the coding molecules found in all living things on earth which contain the instructions on how to build living things. Its is comprised the nucleotide molecules which are ...Read more