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Doctor insights on: Alpha Globin Gene Sequencing

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Does alpha thalassemia trait have gene therapy available?

Does alpha thalassemia trait have gene therapy available?

No: Alpha thalassemia trait only causes mild anemia, and the person usually has no symptoms. Gene therapy is not available and would not be needed. ...Read more

Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


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Can you tell me how is the gene for alpha thalassemia an adaptive trait?

Can you tell me how is the gene for alpha thalassemia an adaptive trait?

Adaptive?: Not certain what you mean. Alpha Thal trait is a genetic--hereditary finding, which was shared with you by either your Mom or Dad. It is not adaptive as sickle cell trai/disease to help prevent malaria, to my knowledge. ...Read more

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Can you tell me why PCR and DNA sequencing provided no results for brent's pathogen.?

Can you tell me why PCR and DNA sequencing provided no results for brent's pathogen.?

Homework: This is the last line from a long homework problem that's already all over other answer boards. It's not appropriate to bring it here, and without the rest of the problem, we can't answer it anyway. ...Read more

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Can you tell me how is the gene for alpha thalassemia an adaptive trait?

Adaptive?: Not certain what you mean. Alpha Thal trait is a genetic--hereditary finding, which was shared with you by either your Mom or Dad. It is not adaptive as sickle cell trai/disease to help prevent malaria, to my knowledge. ...Read more

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What is the difference in gene sequencing tests vs gene deletion/duplication tests? Should one type of genetic test be done before the other?

What is the difference in gene sequencing tests vs gene deletion/duplication tests? Should one type of genetic test be done before the other?

Depends: Sequencing is like reading war and peace letter by letter, and deletion/duplication testing is like seeing if a chapter is completely missing or present as an extra copy. Which first? Depends on the condition. For duchenne muscular dystrophy, look for deletions first. For brca, sequence first. Your clinical geneticist can discuss the strategy with you. ...Read more

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My brother has alpha 1 antiitrypsin gene with his liver affected, Awaiting my own results. What are my odds of having it? Should my kids be tested?

My brother has alpha 1 antiitrypsin gene with his liver affected, Awaiting my own results. What are my odds of having it? Should my kids be tested?

Variable: Alpha 1 antitrypsin disease results (usually) when two unaffected carriers donate their recessive gene to the offspring. With 2 abnormal genes, the medical condition can be expressed. If you share the same parents, you have 3 potential outcomes. Normal, with two normal genes; a carrier with one normal and one abnormal: or you have it but don't know it (unlikely). 2:1 carrier than normal ...Read more

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Does alpha thalassemia trait have gene therapy available?

No: Alpha thalassemia trait only causes mild anemia, and the person usually has no symptoms. Gene therapy is not available and would not be needed. ...Read more

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Please exlain alpha-fetoprotein testing for genetic disorders?

Please exlain alpha-fetoprotein testing for genetic disorders?

Alpha fetal protein: AFP is a fetal specific globulin, synthesized by the fetal yolk sac, gastrointestinal tract, and liver. The function of AFP is unknown. AFP blood levels can be measured during the second trimester to screen for open spina bifida and anencephaly, but can also uncover fetal abnormalities such as abdominal wall defects. AFP is also used in screening tests for downs syndrome and edwards syndrome. ...Read more

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Can you tell me why PCR and DNA sequencing provided no results for brents pathogen.?

Can you tell me why PCR and DNA sequencing provided no results for brents pathogen.?

Homework: This is a question from a homework problem in microbiology that's already all over the answer boards. It's not appropriate to bring it here. ...Read more

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How to differentiate between alpha thalassaemia trait and hb h disease without a genetic test?

Electrophoresis, but: Levels of hemoglobin h and hemoglobin barts should make the distinction straightforward though there may be modifying genes that could make interpretation. The real question is the implications in planning your family and for this perhaps you would like to have genetic testing done. Any hematologist would probably enjoy helping you out. Good luck. ...Read more

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How much DNA is needed for nanopore sequencing?

How much DNA is needed for nanopore sequencing?

A future scientist: How much do you think is required? A single strand? A single molecule? I encourage you to find the answer. Best of wishes to your future endeavors. ...Read more

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Can you tell me why PCR and DNA sequencing provided no results for brent's pathogen.?

Homework: This is the last line from a long homework problem that's already all over other answer boards. It's not appropriate to bring it here, and without the rest of the problem, we can't answer it anyway. ...Read more

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Sev. Dev. Delay -array comparative genetic hybridization (acgh) results indicate no abnormalities- would full genetic sequencing be advised (knome)?

Sev. Dev. Delay -array comparative genetic hybridization (acgh) results indicate no abnormalities- would full genetic sequencing be advised (knome)?

Not necessarily: Newer genetic tests provide incite into a variety of issues like autism & other developmental variations. Yet causation remains elusive in many cases. Sadly, an injury to the developing brain centers from an unrecognized event in an otherwise normal pregnancy is a likely cause for many. This occurs in at least half of cerebral palsy cases & dev. Delay could be produced in others, yet hard to prove. ...Read more

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What ages healthy people the most? Wrong food or exercise? Genes?

Difficult call.: Exposure to uv radiation (sun), tobacco use, and excess alcohol or drug use are the things doctors see that make people appear "older than stated age". After avoiding those insults, to me, the *right* food does most to reverse aging. Eating right can even turn on the right genes to promote a healthier you. See books by drs fuhrman, mcdougall, and barnard or go to forksoverknives. Com. ...Read more

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I am darker than how I was when I was much younger and I don't know why, I am unsure if it is genes or nothing cause I am the darkest in my family!!!!

I am darker than how I was when I was much younger and I don't know why, I am unsure if it is genes or nothing cause I am the darkest in my family!!!!

It may be normal: Darkening pigmentation can be part of your genetics. However sometimes we think about other causes of that amd this is something you need to talk to your physician about. With an appropriate evaluation your physician should be able to answer your question better ...Read more

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How do you no other than age & genes when to get a mammogram.

How do you no other than age & genes when to get a mammogram.

Mammogram: A thorough history and physical by your doctor will help determine whether you are at increased risk, and if you need to begin screening earlier. If you feel a lump, or have another breast related symptom, see your doctor... You made need breast imaging, likely an ultrasound and possibly a mammogram. ...Read more

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Is it genes or lifestyle or both that make it likely to get anll?

Is it genes or lifestyle or both that make it likely to get anll?

Both: An old axiom is everyones phenotype (how they appear- their illnesses etc) is due to their genes plus the environment plus the interaction of the 2.... ...Read more

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Can you still have a normal baby if you have a translocation on one of your genes?

Can you still have a normal baby if you have a translocation on one of your genes?

Translocation chrom: A carrier of a translocation chromosome is normal. When a carrier goes to reproduce however, sometimes the translocation increases the risk of a miscarriage or a chromosomally abnormal baby. Risks are different for different translocations. Prenatal diagnosis can find out if the chromosomes in the fetus are normal or not. ...Read more

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Do my genes control how much I weigh after puberty?

Not directly: Key elements in weight are calories in (food) and calories out (energy used-usually physical activity) genes may modify both and therefore indirectly impact weight but remembering the basics should allow a healthy outcome. ...Read more

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What quantity of genes have been associated with asthma to date?

What quantity of genes have been associated with asthma to date?

Hard to say: Though there seems to be a family link, the specific genes involved have really not been identified. Indeed there may be many genetic links involved so pinpointing exactly which ones are involved may be down the road. ...Read more

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How can I know the length of an intronic region of specific gene?

How can I know the length of an intronic region of specific gene?

Extremely variable: The length of an intron is extremely variable. Even within the same gene, the introns of vastly different lengths can exist. Depending on the statistical method used, the average intron size is somewhere between 3500 base pairs and 5000 base pairs. ...Read more

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Can malaria affect your genes so your children can inherit mental illness?

Can malaria affect your genes so your children can inherit mental illness?

No: Malaria is not associated with mental illness. Some mental health disorders have some genetic basis. However some people with mental health disorders have no other family members with mental health problems. Here is a website to explain more about mental health disorders:
nami- national alliance for mental illness
http://www. Nami. Org/template. Cfm? Section=by_illness. ...Read more

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Mom always did facial exercises and looks great at 90. Did they or genes help?

Genetics: Its amazing how far good genetic inheritance will take you, but remember you only get half from mom. Facial excersize can increase muscle size enough to compensate for loss of facial volume which occur naturally with age. ...Read more

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If a person carries both genes associated with celiac, what are their chances of developing celiac disease?

If a person carries both genes associated with celiac, what are their chances of developing celiac disease?

No guarantee, but...: ...risk is elevated. Keep that risk in mind at all times since clinical presentation of celiac disease varies from patient to patient with either typical intestinal symptoms (see earlier healthtap answers on this topic) or a host of atypical extraintestinal manifestations. Important complications include: malnutrition, osteoporosis, infertility, GI cancers. ...Read more

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Recently I've found out that my daughter has asperger. What is the possibility of me passing it on through the genes? Thank you for your info to

Recently I've found out that my daughter has asperger. What is the possibility of me passing it on through the genes? Thank you for your info to

Aspergers: The exact cause has not been established. There is a likelihood that it is partly genetic but it is not conclusive. See a genetic counsellor for further information and support. All the best. ...Read more

Gene (Definition)

A hereditary unit consisting of a sequence of dna that occupies a specific location on a chromosome and determines a particular characteristic in an organism. Genes undergo mutation when their dna sequence ...Read more


Dna (Definition)

Dna are the coding molecules found in all living things on earth which contain the instructions on how to build living things. Its is comprised the nucleotide molecules which are ...Read more