Doctor insights on:
Alpha Fetoprotein Test Normal Range
Is AFP (Alpha Fetoprotein) test used to detect any kind of cancer in the body? I.e higher value will indicate that there is cancer somewhere in body.
Liver and germ cell:
AFP can be elevated in cancers of the liver and some germ cell tumors. However, it also be elevated in patients with non-cancerous liver disease. The AFP results need to be interpreted in the clinical context. It is not a general marker for cancer.
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Quad Screen: This non-invasive prenatal screening blood (serum) test is done around 12 weeks gestation to see if the fetus may have down's syndrome (trisomy 21) or trisomy 18. It is often combined with a transvaginal ultrasound for better accuracy. This test is not diagnostic. If the screening test is worrisome, then an amniocentesis is usually recommended. Read more
QUAD screen.: Historically performed between 16-20 weeks, the maternal serum quadruple screen (quad) is likely to fall by the wayside now that cell-free fetal dna can actually be tested from the maternal blood (maternit21 and others). Quad is a screening - not diagnostic - test. Read moreSee 1 more doctor answer
I had an amniotic fluid test which showed a high concentration of alpha-fetoprotein. What does this mean?
1980's: The Alpha fetoprotein test was around when I was a resident physician. The test has progressed through the y ears such that there are four levels measured in the pregnant woman's blood looking for the risk of down's syndrome (trisomy 21), trisomy 18 & neural tube defects like spina bifida. This is called the quadruple screen best measured between 16 & weeks of pregnancy. Read more
Alphafetoprotein: Very low levels of AFP measured between 16-18 weeks of pregnancy can be associated with chromosomal abnormalities in the fetus, most commonly down's syndrome. Further testing by amniocentesis will rule this out. It may also b a red flag for intrauterine growth restriction and preterm birth. Will need closer observation and testing. Read more
Different diseases: In pregnancy, elevated alpha fetoprotein levels in a woman's serum can indicate fetal abnormalities, like neural tube defects (spina bifida) or ventral wall defects like omphalocele. Outside pregnancy the levels can be elevated in liver cancer or cancer of the germ cells (ovary, testes). Read more
Increased tesing: An elevation of the Alpha fetoprotein test should alert your doctor that there may be an increased risk of genetic abnormalities such as down's syndrome in the baby. Pregnant women are offered a more detailed ultrasound test looking for signs of genetic problems & are usually offered an amniocentesis which lets you know the chromosomes of the baby. Down's is also known as trisomy 21. Read more
Alpha fetal protein: AFP is a fetal specific globulin, synthesized by the fetal yolk sac, gastrointestinal tract, and liver. The function of AFP is unknown. AFP blood levels can be measured during the second trimester to screen for open spina bifida and anencephaly, but can also uncover fetal abnormalities such as abdominal wall defects. AFP is also used in screening tests for downs syndrome and edwards syndrome. Read more
Dehydration and labs: Dehydration can raise some blood values. Most notably, sodium, chloride, BUN and creatinine are elevated due to less water in the blood. Likewise, Alpha fetoprotein can also be elevated and you would have to see how how the elevation is and how the severe the patient's dehydration was at the time the blood sample was taken. Ask the physician who ordered the test for her input. Read more
What do you suggest if my female friend has an alpha-fetoprotein (afp) number of 20.91 ng/ml. . .?
Pregnant or not?: Alpha-fetoprotein (AFP) is used during pregnancy as part of the "Quad Screen". This is a test that includes AFP and three other blood chemicals to screen for Trisomy 18, Trisomy 21 and Neural Tube defects. If the quad screen is abnormal, a referral to see a perinatologist for a detailed ultrasound and additional testing is in order. AFP can also be tested as part of a cancer work-up. Read more
AFP=29: Normal range for AFP in 15-18-week-pregnant female is 10-150 ng/ml or mcg/l; normal range in non-pregnant female is 0-40 ng/ml or mcg/l. See chart for interpretation of high or low values (yours is in normal range). Read more
Alpha feto protein: An elevation of Alpha feto protein between 15-18 weeks in pregnancy may be asign of a defect in the forming fetal spine (neural tubr defect). It requires a specialized ultrasound imaging to rule out the above possibility. You must speak with your doctor and seek adequate care. Read more
Low AFP: Low AFP is associated with Down's syndrome, but some women do have a low AFP that is unexplained. At 39 you should have already been offered a level 2 ultrasound and genetic testing. If you don't feel comfortable with having an amniocentesis, a cell free dNA test can be done through your blood. Read more
Mom age 60 ct: large lobulated mixed hypodense masses of 15x10 cm in toto in right lobe of liver afp alpha-fetoprotein = 4.46 iu/ml is cancer or not?
Mom and liver spot: Unfortunately, nothing on a ct, regardless of lab studies like AFP gives a definitive diagnosis. An elevated AFP blood test is seen in about 60% of liver cancer patients. So 40% of patients with liver cancer may have normal AFP levels (less than 10) which do not exclude cancer. The major issue is the mass which must be biopsied to get a diagnosis, after which a plan can be made. Read more