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Doctor insights on: Alpha Adrenergic Agonist Side Effects

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Agonist (Definition)

An agonist is a chemical that binds to a receptor on a cell and triggers a response by that cell. An agonist usually mimics the action of the naturally occuring substance. An antagonist does just the opposite, blocking the ...Read more


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With which alpha adrenergic blocking drug is less chance of orthostatic hypotension sideeffect than tamsulosin?

With which alpha adrenergic blocking drug is less chance of orthostatic hypotension sideeffect than tamsulosin?

none: Any Alpha adrenergic blocker will cause oh. A drug with a different mechanism, such as dutasteride, will not (but has its own type of side effects). Sorry! ...Read more

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Do gnrh agonists have side effects?

Do gnrh agonists have side effects?

Absolutely: These drugs can cause a temporary medical menopausal state with all of the associated symptoms, ie, hotflashes, vaginal dryness, sleep disturbances, mood swings, etc. ...Read more

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What are known side effects of ppar agonists? Like fibrates etc..

What are known side effects of ppar agonists? Like fibrates etc..

Fibrate Side Effect: Myotoxicity (muscle damage, rhabdo) is one, especially when used with statins. Liver enzyme elevation is not uncommon. Creatinine (a kidney lab #) elevation may be seen but not necessarily bad; pancreatitis may be seen, extremely rare. Other serious but extremely rare side effects are possible. Generally safe when doctor prescribed & monitored. Muscle aches = stop & call dr asap; + dark urine=>er. ...Read more

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Do Dopamine agonists for Restless Leg Syndrome cross the Blood Brain Barrier? If not, why are side effects like psychosis possible?

Do Dopamine agonists for Restless Leg Syndrome cross the Blood Brain Barrier? If not, why are side effects like psychosis possible?

Clarification: Of course, dopamine agonists cross the brain-blood barrier and interact with appropriate receptors. I suggest you sit down face to face with your doctor and discuss all of your misgivings. ...Read more

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What's better for a nasal congestion? Steroids, antihistamines or alpha agonists?

What's better for a nasal congestion? Steroids, antihistamines or alpha agonists?

Best to treat cause: It's best to treat the cause of the nasal congestion (allergies, sinus infection, etc.) but for symptomatic relief of the congestion i suggest a steroid nasal spray and oral decongestant if needed. Different steroid nasal sprays may need to be tried to find one that is most effective. ...Read more

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Taking 1mg of Tenex (Guanfacine) every night made me somewhat hypersexual. However, taking 2mg several days ago made me impotent. Can someone please explain how alpha-2 agonists cause impotence?

Taking 1mg of Tenex (Guanfacine) every night made me somewhat hypersexual. However, taking 2mg several days ago made me impotent. Can someone please explain how alpha-2 agonists cause impotence?

Alpha 1&2 receptors: Try one and one half. It seems that alpha 2 blockade is used in impotence to increase nitric oxide, but it seems you need both alpha 1 and 2 blockade to block vasoconstriction, since alpha 2 also block the release of norepinephrine and that will increase with alpha blockers. http://www.ncbi.nlm.nih.gov/pubmed/10845761 ...Read more

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Is it possible to attenuate the side effects of smoking cessation with Alpha GDC?

Is it possible to attenuate the side effects of smoking cessation with Alpha GDC?

Alpha-GPC ?: Alpha-glycerophosphocholine (Alpha-GPC or ?-GPC) is a dietery supplement that is a source of choline. People claim cognitive-promoting properties, and athletes use it to try to enhance power output. It is unlikely to improve side effects of smoking cessation. ...Read more

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Stopped Milk Thistle + Alpha Lipoic Acid due to side effects, how long before lethargy from it wears off? My energy was great before and now crashing!

Stopped Milk Thistle + Alpha Lipoic Acid due to side effects, how long before lethargy from it wears off? My energy was great before and now crashing!

Milk thistle should: help, and not make it worse, and it's effects should be cleared within a day. See doctor if energy level is crashing. This is not normal, when you had great energy before. ...Read more

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I take risperidone. It has cognitive sideffects due to anticholinergic activity. What can I do to treat it? Will Alpha GPC, choline or lecithin help?

I take risperidone. It has cognitive sideffects due to anticholinergic activity. What can I do to treat it? Will Alpha GPC, choline or lecithin help?

Dose of Risperdone: important. See more anticholinergic side effects at doses greater than 1 mg. Parkinsonism above mg. Concomitant use of Ginko may worsen situation. Ginko has not shown to improve long term cogntive issues. One study in China with concomitant use of Risperdal has been completed but results are unavailable at this time. Another study looking at use of Risperdal with Ginko in autism showed no benefit. ...Read more

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Need expert advice on effects of orchidectomy and lhrh agonist drugs on prostate cancer?

Need expert advice on effects of orchidectomy and lhrh agonist drugs on prostate cancer?

Lower testosterone: Orchiectomy and lhrh agonist medications are performed to lower the production of testosterone (fuel that promotes prostate cancer growth). Both will cause a man's testosterone to drop typically lower than 50 (normal >300). Will slow prostate cancer growth but not "cure" it. Side-effects of castration include hot-flashes, osteoporosis, diabetes/cardiovascular risks, etc. Discuss with urologist. ...Read more

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Can anyone tell me is Zoloft (sertraline) an agonist or antagonist?

Can anyone tell me is Zoloft (sertraline) an agonist or antagonist?

SSRI: Zoloft (sertraline) is a selective serotonin re-uptake inhibitor. It stops the nerve cell from removing the neurotransmitter serotonin from the synapse, thus making more serotonin available to the cell. In theory it temporarily disengages the re-uptake mechanism. ...Read more

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Is luvox (fluvoxamine) the only ssri that is a sigma agonist...And is that why it is better for anxiety..Explain sigma a sigma agonist?

Is luvox (fluvoxamine) the only ssri that is a sigma agonist...And is that why it is better for anxiety..Explain sigma a sigma agonist?

See Wikipedia : Drugs known to be ?–agonists include cocaine, morphine/diacetylmorphine, opipramol, pcp, fluvoxamine, methamphetamine, dextromethorphan, and the herbal antidepressant berberine. However the exact role of ?–receptors is difficult to establish as many ?–agonists also bind to other targets such as the ?-opioid receptor and the nmda receptor.Recently selective ?–receptor agonists were shown to produceantidepressant effects in mice. Best wishes. ...Read more

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Is risperdal dopamine agonist?

Is risperdal dopamine agonist?

No: How Risperdal (also called risperidone) works isn't entirely clear. It does act on Dopamine receptors, but it's an antagonist. It's also a serotonin receptor antagonist. ...Read more

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