Doctor insights on:
Alpha 1 Antitypsin
Diagnosis of AAT def: Alpha-1-antitrypsin is a protease inhibitor of the enzyme elastase. Deficiency can result in disease of the lung, liver, and skin. The serum level is quantified in the diagnosis of aat deficiency. If the aat serum level is greater than 80 mg/dl, it is unlikely that the patient has clinically significant aat deficiency. ...Read more
No: It may be mild or severe. You're born with it, you are likely to become short of breath in middle age (hopefully you are a non-smoker), and the liver disease may come on at any time in your life, or never. ...Read more
AAT deficiency: Measurement of alpha-1-antitrypsin serum concentration is used to determine if a patient has the inherited disorder aat deficiency. If the aat serum level is greater than 80 mg/dl, it is unlikely that the patient has clinically significant aat deficiency. ...Read moreSee 1 more doctor answer
What does " ALPHA-1-ANTITRYPSIN " mean?Component Standard Range Your Value 90 - 200 mg 218
why is mine elevated?
Alpha-1: Alpha-1-antitrypsin is a protein produced by the liver which helps to protect the liver and lungs from damage. Approximately 1 in 2,500 people have a deficiency (hereditary) which puts them at higher risk for early lung (COPD) and liver disease (cirrhosis, cancer). This deficiency can be detected by a blood test. ...Read moreSee 1 more doctor answer
Any: Shortness of breath usually develops from the lung disease in the 40's. The liver disease can show up at any age from infancy to later middle age, or never. Nobody knows why. ...Read more
I had a stoolanalysis done and found out that I have a high pH value (8.0) and an increased level of Alpha-1-Antitrypsin (34,2 U/ml). Whatdoesthismean?
Probably not much: Stool pH varies chaotically with diet and what bugs happen to be there. Stool antitrypsin is sometimes used to screen for protein-losing enteropathy. The units you give are not standard but I'll assume that they're elevated. If they are greatly above reference range, it's one more piece of information for the workup, suggesting at least some of the gut lining is significantly damaged. ...Read more
Genetic disease: It's quite variable in severity. The lack of the helpful antitrypsin protein in the blood prevents the neutralization of enzymes from white cells that tend to decrease the elasticity of the lungs. The enzyme itself accumulates in the liver which can't get it into the circulation and this can ruin the liver. This can happen at any age and no one knows why it varies so much; or the liver may be fine. ...Read more
Blood test: Blood, more accurately serum, is examined for levels of Alpha 1 at. Electophoresis of serum also reveals deficiency and a detailed electrophoresis, iso-electric focusing, provides details of the abnormal protein. Dna also can be tested to ascertain the abnormality in the gene. ...Read more
Genetic, familial: Genetic abnormality that can run in families, associated with emphysema, even without the usual triggers like tobacco use, and cirrhosis of the liver, even in the absence of triggers like chronic infection, alcohol use. Can cause problems in children and/or in adults. Can be tested for, can be rx'd. ...Read more
Emphysema: Aat deficiency affects primarily the lungs, leading to copd, particularly a panacinar emphysema. Symptoms are variable, but usually involve shortness of breath on exertion, cough, or wheezing. It can also affect the liver, causing chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Necrotizing panniculitis is a rare clinical manifestation involving the skin. ...Read more