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Doctor insights on: Alpha 1 Antitrypsin Deficiency Emphysema And Chronic Gastrointestinal Bleeding

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What is the link between the alpha-1 antitrypsin deficiency and the emphysema ?

What is the link between the alpha-1 antitrypsin deficiency and the emphysema ?

Destruction: Alpha-1 anti-trypsin is a protective chemical in the body that prevents destruction of lung and other tissues from the damage that the infection fighting cells can inflict. When you have a lack of this chemical, the destruction of the infection fighting cells in the body can go unopposed. This is especially true when someone smokes, which attracts those cells to fight off the toxins in the smoke. ...Read more

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Copd (Definition)

COPD may include chronic bronchitis, emphysema, or both. Chronic bronchitis is the production of increased mucus caused by inflammation. Bronchitis is considered chronic if you cough and produce excess mucus most days for three months in a year, two years in a row. Emphysema is a disease that damages the air sacs and/or the smallest breathing tubes in the lungs. ...Read more


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Which is the link btwn the alpha-1 antitrypsin deficiency and the emphysema ?

Which is the link btwn the alpha-1 antitrypsin deficiency and the emphysema ?

Proteases: Alpha-1-antitrypsin is a protease inhibitor. It is elevated in inflammation to keep the proteases in check which cause tissue damage. Its deficiency allows the neutrophil elastin protease to destroy elastin which are the necessary components in the elasticity of the lung and cause the destruction of the interstitial tissues and cause emphysema. ...Read more

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Should a child with COPD have a blood test, to rule out alpha 1 antitrypsin deficiency?

Should a child with COPD have a blood test, to rule out alpha 1 antitrypsin deficiency?

Probably...: If a child has copd, and not asthma, then an alpha-1-anti trypsin level probably ought to be checked. The child needs to have an evaluation so the proper diagnosis and treatment can be given! ...Read more

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Could marijuana smoking be dangerous when you are a carrier for alpha-1 antitrypsin deficiency?

Could marijuana smoking be dangerous when you are a carrier for alpha-1 antitrypsin deficiency?

Smoking Marijuana?: Smoking marihuana can cause u to have symptoms similar to schizophrenia and can cause u to be in a motivational state. U r still 18 years old if u r not motivated , how can u succeed in life?! ...Read more

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Anyone with an alpha-1 antitrypsin deficiency with liver problems?

Anyone with an alpha-1 antitrypsin deficiency with liver problems?

Yes: People with the zz phenotype for alpha1antitrypsin can develop early emphysema, as well as liver disease. Although rare, some of the heterozygotes, e.g. Those with the mz phenotype may also develop lung disease and or liver disease. Go to www.Alphaone.Org. ...Read more

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Could there be a connection between alpha 1 antitrypsin deficiency and smoking marijuana?

Not sure: This is an interesting question as Alpha 1 antitrypsin deficiency is not "caused" by cigarette smoking, but can certainly be aggravated by it. Thus, i think it is safe to say that any smoking may aggravate the symptoms of Alpha 1, but i don't think that there is a direct connection as smoking marijuana does not have primary affect on the enzyme activity. ...Read more

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My grandmother had alpha-1 antitrypsin deficiency, should I be tested for it?

My grandmother had alpha-1 antitrypsin deficiency, should I be tested for it?

Alpha 1 antitrypsin: The genetics of this deficiency is complicated. The test is widely available for screening. Your question requires an understanding of the implications of a positive test, so that a discussion and or consultation with a geneticist is probably a good idea. ...Read more

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My mom was tested for Alpha 1 antitrypsin Deficiency, her lab report says her result is 1.65 and the reference range is 1.09-2.88. Interpretation plz?

My mom was tested for Alpha 1 antitrypsin Deficiency, her lab report says her result is 1.65 and the reference range is 1.09-2.88. Interpretation plz?

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, from the data you provided, you mother is not deficient in alpha 1 anti-trypsin. ...Read more

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What is alpha-1 antitrypsin deficiency and what do I do about it?

What is alpha-1 antitrypsin deficiency and what do I do about it?

Genetic problem: Because of this gene mutation, body becomes deficient in Alpha -1 - antitrypsin protein and manifests as chronic lung disease, just like in COPD pts but affects a younger population and affects the bases of the lung more than the apices.. Fortunately it is available to take on a daily basis to bring the levels of a1at within 'normal' range. ...Read more

Dr. K. Mujib Haque
412 doctors shared insights

Gastrointestinal Bleeding (Definition)

A long tube runs from the mouth to the anus. It includes, in order, the mouth, throat, esophagus, stomach, small intestine (duodenum, jejunum, ileus), caecum, the ascending, transverse, descending, and sigmoid colon (or large intestine) and the rectum. The space inside that tube , the lumen, is considered to be outside of the body. When we bleed into that space ...Read more


Dr. Sue Ferranti
491 doctors shared insights

Emphysema (Definition)

Emphysema is a lung disease caused by destruction of lung tissue--specifically the alveoli, which are the smallest sac-like units of the lung responsible for oxygen exchange. It is characterized by shortness of breath, an expanded chest, and possible signs of low oxygen in the body such as bluish ...Read more