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Doctor insights on: Allergic To Antihistamines

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Have you ever heard of anyone w/true allergy to benadryl (diphenhydramine)? Would this allergy be likely to turn serious? How can someone be allergic to antihistamines?

Have you ever heard of anyone w/true allergy to benadryl (diphenhydramine)? Would this allergy be likely to turn serious? How can someone be allergic to antihistamines?

Yes: Good question. It is very rare but does happen. Sometimes they are not allergic to the Diphenhydramine but the dyes and fillers used to make the medicine. But people have also had reactions to dye free benadryl (diphenhydramine). You can develop an allergy to anything. I have seen people with Benadryl (diphenhydramine) allergy who could take other antihistamines such as hydroxyzine. ...Read more

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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Are anti nausea drugs in the same family as antihistamines? I'm allergic to anti nausea drugs, dr is now saying i'm allergic to antihistamines ?

Are anti nausea drugs in the same family as antihistamines? I'm allergic to anti nausea drugs, dr is now saying i'm allergic to antihistamines ?

There are : Many different types of anti-nausea medications, but none of them are anti-histamines. I don't know why your doctor is correlating the them. Perhaps he has another reason. Ask him. ...Read more

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When i take oral antihistamines i get hives over my entire body. Is it possible to be allergic to antihistamines? What can be taken instead?

When i take oral antihistamines i get hives over my entire body. Is it possible to be allergic to antihistamines? What can be taken instead?

Unlikely: Each antihistamine is unique, so it is unlikely that you would be allergic to multiple antihistamines. I had one patient who had hives to an antihistamine, and it turned out to be an allergy to a dye. You should consult with someone familiar with these medications and medication reactions in general, such as an allergist. ...Read more

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I have been given orphenadrine for muscle spasms in the back, but i'm allergic to antihistamines , is this safe to take ? ...

I have been given orphenadrine for muscle spasms in the back, but i'm allergic to antihistamines , is this safe to take ? ...

Talk to your doctor: If you have been tolerating orphenadrine, perhaps you do not have an allergy to antihistamines but may have had a side effect from one of them. Talk to your prescribing doctor about this. ...Read more

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My doc says cos I'm allergic to ondansetron that I'm also allergic to antihistamines, what can I use for gritty itchy eyes due to spring allergies?

My doc says cos I'm allergic to ondansetron that I'm also allergic to antihistamines, what can I use for gritty itchy eyes due to spring allergies?

Huh?: Ondansetron allergy is very uncommon. I am no allergist, but there is no apparent overlap between the antihistamine H1 and H2 receptor and the antiemetic HT3 receptor that I am aware of. In addition, antihistamines have been used as part of the treatment of ondansteron allergy. I suggest you clear this up with your doc. ...Read more

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Is it possible for someone to be allergic to every antihistamine?

Is it possible for someone to be allergic to every antihistamine?

No: People may not be able to tolerate the side effects from antihistamines but not allergic to all of them. In fact, allergy to antihistamine has not been documented except for perhaps contact sensitization to topical benadryl (diphenhydramine). ...Read more

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Is it possible to be allergic to all antihistamines?

Is it possible to be allergic to all antihistamines?

Unlikely: Please define your symptoms from the medications. Theoretically someone can be reacting to a coating on the tablets, but rarely do people react to antihistamines beside the usually sedative side effects. ...Read more

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Is it possible to be allergic to all antihistamines (hives)? I see hives 90mins after taking 3 different antihit's on different days.

See a dermatologist: Why taking antihistamine? When you see the dr be prepared to name all antihistamines tried. Exact names. It is possible but very unlikely to get hives from antihistamines: they are used to stop hives. ...Read more

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Is it possible for a person to be allergic to all antihistamines? (not the die but the active ingredients itself, ie cyclizine, meclozine)

Is it possible for a person to be allergic to all antihistamines? (not the die but the active ingredients itself, ie cyclizine, meclozine)

Allergy: In medicine, anything is possible. However it would be unusual to be allergic to all antihistamines because there are different drug molecules with antihistaminic action that are different in molecular structure and in mechanism of action. If your question is related to a specific clinical situation see your doctor for a substitute medicine. ...Read more

Dr. Paul Carter
601 doctors shared insights

Antihistamine (Definition)

Sedating and non-sedating antihistamines prevent and treat allergic reactions, and are ...Read more