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Doctor insights on: Alagille Syndrome

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Dr. Lawrence Prince
75 doctors shared insights

Alagille Syndrome (Overview)

Alagille syndrome is a genetic disorder that can affect the liver, heart, and other parts of the body. One of the major features of Alagille syndrome is liver damage caused by abnormalities in the bile ducts. These ducts carry bile (which helps to digest fats) from the liver to the gallbladder and small intestine. In Alagille syndrome, the bile ducts may be narrow, malformed, and reduced in number


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What exactly is alagille syndrome?

What exactly is alagille syndrome?

Genetic abnormality: Genetic abnormality, autosomal dominant, has multi-organ problems; affects liver/bile ducts, pulmonic heart valve, kidney, eye, bone, neurologic/mental problems, characteristic facial features. Variable intensity of findings; can be dx'd infancy, milder cases as adult. May need meds, vits, heart, liver surgery, even transplant. Variety of nutritional issues, vits a, d, e, k, zinc, fats, cholesterol. ...Read more

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Dr. Lawrence Prince
75 doctors shared insights

Alagille Syndrome (Overview)

Alagille syndrome is a genetic disorder that can affect the liver, heart, and other parts of the body. One of the major features of Alagille syndrome is liver damage caused by abnormalities in the bile ducts. These ducts carry bile (which helps to digest fats) from the liver to the gallbladder and small intestine. In Alagille syndrome, the bile ducts may be narrow, malformed, and reduced in number


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What are the symptoms of alagille syndrome?

What are the symptoms of alagille syndrome?

Jaundice: Alagille syndrome is an autosomal dominant inherited rare condition that primarily affects the liver. Symptoms can be mild or so severe as to require liver transplantation. Jaundice and skin itching are the primary symptoms. ...Read more

Dr. John Landi Dr. Landi
<b>1</b> doctor agreed:
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Managing Restless Leg Syndrome (Checklist)

See a vein specialist
Once
Check cholesterol medications
Once
Have a venous ultrasound to check for reflux
Once
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Need some more info. About the causes and signs of alagille syndrome please help!?

Need some more info. About the causes and signs of alagille syndrome please help!?

Genetic disease: Alagille syndrome is a genetic disease which most importantly affects the liver. Significant congenital heart disease also is common. Over 90% of affected patients have a mutation or deletion in the jag1 gene. The liver disease is characterized by abnormal bile ducts. Each individual is affected differently, from mild effects to severe liver failure requiring transplantation. ...Read more

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What are the tests for alagille syndrome?

What are the tests for alagille syndrome?

Liver biopsy: Liver biopsy is probably the most effective means of diagnosis. Many people with alagille syndrome do have characteristic facial features and some unusual x-ray findings but not in all cases. ...Read more

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Dr. Joshua Batt Dr. Batt
<b>1</b> doctor agreed:
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Managing Carpal Tunnel Syndrome (Checklist)

Visit your medical provider for accurate diagnosis
Once
Wear a wrist brace at night
daily
Take pain medications as directed
Once
Use proper posture when performing tasks
Once
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What is the treatment for alagille syndrome?

Supportive care: There is no known cure for this disease. Treatment is directed toward improving heart effects and diminishing the effects of a failing liver. ...Read more

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What exactly is alagille syndrome?

Genetic abnormality: Genetic abnormality, autosomal dominant, has multi-organ problems; affects liver/bile ducts, pulmonic heart valve, kidney, eye, bone, neurologic/mental problems, characteristic facial features. Variable intensity of findings; can be dx'd infancy, milder cases as adult. May need meds, vits, heart, liver surgery, even transplant. Variety of nutritional issues, vits a, d, e, k, zinc, fats, cholesterol. ...Read more

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Dr. Felix Toro Dr. Toro
<b>1</b> doctor agreed:
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Living with Asperger's Syndrome (Checklist)

Learn about your condition
once
Listen, listen, listen
once
Practice stress management and mindfulness
2x day
Do not be afraid to Ask for feedback
3x day
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What are the tests for alagille syndrome?

Liver biopsy: Liver biopsy is probably the most effective means of diagnosis. Many people with alagille syndrome do have characteristic facial features and some unusual x-ray findings but not in all cases. ...Read more

See 1 more doctor answer