Top
40
Doctor insights on: Advanced Multiple Myeloma And Dialysis

Share
Dr. Sandra Lora Cremers
126 doctors shared insights

Kahler Disease (Definition)

I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more


3

3
Are myelofibrosis and multiple myeloma are related to each other?

Are myelofibrosis  and  multiple myeloma are related to each other?

No: They are totally different diseases. Myeloma is a malignancy that develops in a type of blood cell called a plasma cell. Myelofibrosis is a disease of the bone marrow microenvironment. ...Read more

See 1 more doctor answer
4

4
What is the prognosis of life expectancy of someone diagnosed with NSCLC WITH mets to, liver, multiple bones, multiple lymph nodes and brain?

What is the prognosis of life expectancy of someone diagnosed with NSCLC WITH mets to, liver, multiple bones, multiple lymph nodes and brain?

NSCLC: Unfortunately, the prognosis isn't good. One year survival is about 30%. 5 year survival with distant mets is less than 4%. Just remember that statistics are valid for groups. Who knows what grace God might bestow on any individual? ...Read more

5

5
Is their other treatment other than dialysis and transplant for chronic kidney disease ? At stage 4 ..... Is there medication available to repair ?

Is their other treatment other than dialysis and transplant for chronic kidney disease ? At stage 4 .....  Is there medication available to repair ?

Treatment of CKD: At ckd stage 4, you do not need dialysis at present. If you ckd progresses to end stage renal disease, you will need to start on dialysis or have a transplant. You do not list that you have diabetes or hypertension, if the cause of your ckd is polycystic kidney disease, not much can be done for your decline into higher stages of ckd. Your nephrologist is the one to speak to about your prognosis. ...Read more

6

6
What is the life expectancy of people with multiple myeloma and lcdd?

What is the life expectancy of people with multiple myeloma and lcdd?

Depends on heart: The light chain deposition disease is unlikely to affect survival. In fact a review of myeloma and kidney failure published last year demonstrated no change in outcome in myeloma patients with or without kidney failure. The biggest predictor of outcome is response to chemotherapy. Velcade (bortezomib) (new chemo) has been a game changer. In addition, patients with cardiac involvement do very poorly. ...Read more

7

7
In general, what can be some treatment options, besides palliative hospice care, for stage 4 pancreas cancer and extensive liver mets?

In general, what can be some treatment options, besides palliative hospice care, for stage 4 pancreas cancer and extensive liver mets?

Recommend chemothera: There are more than one chemotherapy options. Seek advice from a medical oncologist. A combination of Gemcitabine and Nab Paclitaxel is one recently approved treatment regimen. Other drug regimens like FOLFERINOX are also commonly used. ...Read more

8

8
What are advanced testicular cancer and another advance cancer such as advanced lung cancer?

What are advanced testicular cancer and another advance cancer such as advanced lung cancer?

Variable: Obviously different cells and location of origin. Other adjectives are differentiation - wild growth histology. Once advanced stage includes spread-metastasis and locations. Testicular can go through local and systemic spread. Similarly lung can grow and invade locally and spread broadly. ...Read more

See 1 more doctor answer
9

9
Why are kidney recipients at a higher risk for diabetes, cancer and bone disease?

Why are kidney recipients at a higher risk for diabetes, cancer and bone disease?

Immunosuppression: I am not a kidney transplant specialist, but i still think i can answer. Patients that receive an organ transplant usually need ongoing immunosuppression to prevent rejection. That can include a variety of drugs including steroids. Diabetes, bone loss - steroid induced cancer - immunosuppression drugs. ...Read more

See 1 more doctor answer
10

10
What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?

What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?

Better than before: Most patients can now achieve remission either with standard therapy or stem cell transplant. The remissions can be long lived although patients are not cured. Many live a decade or more with good quality of life and this time line continues to get longer with the new targeted therapies. The average life span used to be 2.5 years. ...Read more

See 1 more doctor answer
11

11
What are the end of life symptoms for advanced adendouscarcina nsclc w/ mets to brain, bones and now liver .14 months dx?

What are the end of life symptoms for advanced  adendouscarcina  nsclc w/ mets to brain, bones and now liver .14 months dx?

Breathless: Frequently pulmonary obstructive symptoms, just cannot breathe, or pneumonia, and fever and sepsis, or metastatic disease in a critical area- brain for example, or the chest fills with fluid, one can break a bone such as hip and fall due to metastasis. ...Read more

See 1 more doctor answer
12

12
Are stem cell transplants for multiple myeloma effective?

Yes.: Autologous stem cells transplants (from yourself as donor when in near remission) result in improved progression free survival and probably overall survival. Allogeneic transplant (from someone else) is more complex, and many would consider it experimental. Although the procedure may cure the disease, there are significant complications and risks that may offset the benefits. ...Read more

14

14
Which groups are most frequently affected by multiple myeloma?

Blacks in US: Twice the incidence in african americans than caucasians. Some families have a higher incidence. ...Read more

See 1 more doctor answer
17

17
Are C-reactive protein (CRP) and ESR levels typically elevated with advanced stage cancer such as stage 4 lymphoma?

Are C-reactive protein (CRP) and ESR levels typically elevated with advanced stage cancer such as stage 4 lymphoma?

No: These tests are neither sensitive nor specific for much. They generate enormous confusion and unnecessary fear. C-RP is made in atherosclerotic plaques and is often up in bad atherosclerosis. It's also made in the liver in response to some interleukins in disease elsewhere, especially some arthritis variants. Sed rate reflects globulins and fibrinogen, not usually up in lymphoma. ...Read more

18

18
Kidney biopsy shows the reason for kidney failure is multiple myeloma. No bone damage, hemo. More than 12. Will kimo therapy help to recover fully?

Seek opinion from a: This is unusual way to make a diagnosis of multiple myeloma(mm). Typically we need to do a bone marrow biopsy and look for cancer cells in the marrow. These cells produce abnormal proteins(m protein) which will show up either in the blood(commonly) or in the urine. We use a test called protein electrophoresis. If these tests have not been done, seek a second opinion. Chemo will help to control mm. ...Read more

19

19
What percentage of patients with multiple myeloma will survive?

It depends: Survival in myeloma depends on a number of factors. First, is stage. Second is chromosomal abnormalities. Some have a good prognosis, others not so good. In general we think that myeloma is not usually curable with standard therapies, but survival is getting better with our newer agents, so that living 10 years is not unusual. Cure may be possible with allogeneic bone marrow transplant. ...Read more

20

20
What is the current prognosis of african american women with multiple myeloma with renal failure?

What is the current prognosis of african american women with multiple myeloma with renal failure?

Depends: This can best be answered by your treating physician. It often depends on age, other medical disorders, previous treatments, response to velcade (bortezomib). Most patients will have improvement in renal failure if this is the first treatment they receive, and the treatment usually includes velcade (bortezomib). ...Read more

21

21
58 Years old diagnosed with Stage IV colorectal cancer and spread to liver with 7+cm tumor and lesions in the lung. What kind of life expectancy?

58 Years old diagnosed with Stage IV colorectal cancer and spread to liver with 7+cm tumor and lesions in the lung. What kind of life expectancy?

It Depends: Recent progress in genetic typing of individual Colon Ca tumors and genetic specific tumor drugs is leading to better understanding of likelihood of treatment success. See: https://www.researchgate.net/profile/Arun_Azad/publication/246837094_Predicting_the_response_to_targeted_therapy_in_metastatic_colorectal_cancer/links/5419c4180cf2218008bf9f8a.pdf I recommend getting into a clinical trial. ...Read more

22

22
How will my doctor know if I have multiple myeloma? 

Labs, xrays: There are a series of blood and urine tests that will give the doctor a good idea if you have the disease. These are usually followed by x-rays looking for tell-tale signs of myeloma and a bone marrow test which would identify the cancer cells themselves. ...Read more

See 1 more doctor answer
23

23
Pl suggest any alternative remedy/ies for multiple myeloma I am 48 yer old and no m band seen at this moment after 6 months of chemo?

Pl suggest any alternative remedy/ies for multiple myeloma  I am 48 yer old and  no m band seen at this moment after 6 months of chemo?

Homeopathy, herbs ;: There are no proven alternatives for multiple myeloma but that does not mean they may not help; but i would continue standard treatments too. A healthy diet, tonifying herbs, reducing body burden of heavy metals ; other environmental toxins, stress reduction ; working to clear unresolved anger/grief etc. Can only help. I also advise classical homeopathy with a good homeopath. See comments for more:. ...Read more

See 1 more doctor answer
24

24
How common is multiple myeloma?

How common is multiple myeloma?

Uncommon: Approximately 1% of all cancers and slightly more than 10 % of blood cancers in the United States. ...Read more

See 1 more doctor answer
25

25
What other tests for multiple myeloma?

What other tests for multiple myeloma?

Blood/Urine/Imaging: Usually workup involves blood and urine tests (spep / upep - serum and urine protein electrophoresis). The preferred initial imaging study is the skeletal survey (x-ray of multiple sites of the body including skull, axial skeleton, and proximal long bones). Bony lesions are usually lytic. ...Read more

See 1 more doctor answer
26

26
What is Multiple myeloma a risk factor for?

Multiple issues: It can lead to anemia, increased calcium , renal failure, bone pain and fractures to name a few ...Read more

See 1 more doctor answer
28

28
What is the definition or description of: multiple myeloma?

Plasma cell cancer: Multiple myeloma is a cancer of plasma cells (pcs). Pcs are the specialized b lymphocytes that produce antibodies. When there is a cancer or one (mono-) clone (= monoclonal, m) pc population they can product m-proteins. Symptoms include crab - hypercalcemia, renal (kidney) insufficiency, anemia, bone disease; also infection and pain. More: http://www.Cancer.Net/cancer-types/multiple-myeloma. ...Read more

29

29
Can you tell me which are the signs of smoulding multiple myeloma?

None: If truly smoldering myeloma, there are no signs. If there are symptoms, then it may be myeloma. Hope this helps. ...Read more

30

30
What is the prognosis of multiple myeloma in terms of survival rates by stage?

See below: Treatment for multiple myeloma has improved markedly and drug treatment alone or drug treatment with auto or donor stem cell transplants can produce decades long remissions. See this site for more info. http://www.mayoclinic.org/diseases-conditions/multiple-myeloma/basics/definition/con-20026607 ...Read more

32

32
Is there a cure for multiple myeloma?

No: However, remission is possible in many cases and many patients can live fairly normal lives for quite some time with the many new advances in this disease. ...Read more

See 1 more doctor answer
33

33
Is multiple myeloma is still not curable?

Not curable: There are many treatments for multiple myeloma and the survival of patients with myeloma is much better than 10 years ago. But we still do not consider this a curable disease. ...Read more

See 1 more doctor answer
34

34
How does multiple myeloma affect the kidney?

How does multiple myeloma affect the kidney?

Nephropathy: Myeloma produces proteins called light chains which can essentially "clog up" the kidney producing myeloma nephropathy. Myeloma also produces humoral substances which can damage the kidney. ...Read more

See 1 more doctor answer
36

36
How long do patients live with multiple myeloma?

How long do patients live with multiple myeloma?

Depends: Myeloma has a variable natural history. Many patients have had myeloma for years prior to diagnosis without realizing it, while others are diagnosed by screening for monoclonal protein in the blood. Modern hematologists can use advanced treatments like velcade, revlimid, (lenalidomide) thalomid, and stem cell transplant, allowing myeloma patients to live longer than ever. More info: http://bit.Ly/lrzotm. ...Read more

See 1 more doctor answer
40

40
What is the life expectancy of people with multiple myeloma?

Much better now: With all the new targeted drugs for myeloma and several to come, patients live many more years. Some have said this cancer is now more like a chronic disease - still dangerous and needing treatment but it is characterized by longer periods of remission after treatment. Therefore a 65 or 75 year old person may have a normal life span with this disease now. ...Read more

See 1 more doctor answer
Dr. Quresh Khairullah
520 doctors shared insights

Dialysis (Definition)

Simple answer is that it is a medical technology used primarily to provide an artificial replacement for lost kidney function in people with renal failure. Hemodialysis remove wastes and excess water from the blood by circulating blood outside the body through an external filter, called a dialyzer. Blood and dialysate flow through in opposite directions and the ...Read more


Dr. Liawaty Ho
754 doctors shared insights

Multiple Myeloma (Definition)

A cancer of the plasma cells, which are responsible for producing antibodies for your body. Symptoms include kidney insufficiency, anemia, bone ...Read more