Doctor insights on:
Advanced Multiple Myeloma And Dialysis
How many diagnostic codes are there? How many that have to with heart, stroke, diabetes, end stage renal, and organ transplants and cancer.
I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more
What is the prognosis of life expectancy of someone diagnosed with NSCLC WITH mets to, liver, multiple bones, multiple lymph nodes and brain?
NSCLC: Unfortunately, the prognosis isn't good. One year survival is about 30%. 5 year survival with distant mets is less than 4%. Just remember that statistics are valid for groups. Who knows what grace God might bestow on any individual? ...Read more
Is their other treatment other than dialysis and transplant for chronic kidney disease ? At stage 4 ..... Is there medication available to repair ?
Treatment of CKD: At ckd stage 4, you do not need dialysis at present. If you ckd progresses to end stage renal disease, you will need to start on dialysis or have a transplant. You do not list that you have diabetes or hypertension, if the cause of your ckd is polycystic kidney disease, not much can be done for your decline into higher stages of ckd. Your nephrologist is the one to speak to about your prognosis. ...Read more
Depends on heart: The light chain deposition disease is unlikely to affect survival. In fact a review of myeloma and kidney failure published last year demonstrated no change in outcome in myeloma patients with or without kidney failure. The biggest predictor of outcome is response to chemotherapy. Velcade (bortezomib) (new chemo) has been a game changer. In addition, patients with cardiac involvement do very poorly. ...Read more
In general, what can be some treatment options, besides palliative hospice care, for stage 4 pancreas cancer and extensive liver mets?
Variable: Obviously different cells and location of origin. Other adjectives are differentiation - wild growth histology. Once advanced stage includes spread-metastasis and locations. Testicular can go through local and systemic spread. Similarly lung can grow and invade locally and spread broadly. ...Read moreSee 1 more doctor answer
Immunosuppression: I am not a kidney transplant specialist, but i still think i can answer. Patients that receive an organ transplant usually need ongoing immunosuppression to prevent rejection. That can include a variety of drugs including steroids. Diabetes, bone loss - steroid induced cancer - immunosuppression drugs. ...Read moreSee 1 more doctor answer
What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?
Better than before: Most patients can now achieve remission either with standard therapy or stem cell transplant. The remissions can be long lived although patients are not cured. Many live a decade or more with good quality of life and this time line continues to get longer with the new targeted therapies. The average life span used to be 2.5 years. ...Read moreSee 1 more doctor answer
What are the end of life symptoms for advanced adendouscarcina nsclc w/ mets to brain, bones and now liver .14 months dx?
Breathless: Frequently pulmonary obstructive symptoms, just cannot breathe, or pneumonia, and fever and sepsis, or metastatic disease in a critical area- brain for example, or the chest fills with fluid, one can break a bone such as hip and fall due to metastasis. ...Read moreSee 1 more doctor answer
Yes.: Autologous stem cells transplants (from yourself as donor when in near remission) result in improved progression free survival and probably overall survival. Allogeneic transplant (from someone else) is more complex, and many would consider it experimental. Although the procedure may cure the disease, there are significant complications and risks that may offset the benefits. ...Read more
Pt. with renal cell cancer develop metastates to the pelvic bone
what are the treatment of such pt..
Chemotherapy: and RadiationGet a more detailed answer ›
What medications for peripheral neuropathy are safest for someone with reduced kidney function (gfr = 38, all other kidney tests are normal)?
Are C-reactive protein (CRP) and ESR levels typically elevated with advanced stage cancer such as stage 4 lymphoma?
No: These tests are neither sensitive nor specific for much. They generate enormous confusion and unnecessary fear. C-RP is made in atherosclerotic plaques and is often up in bad atherosclerosis. It's also made in the liver in response to some interleukins in disease elsewhere, especially some arthritis variants. Sed rate reflects globulins and fibrinogen, not usually up in lymphoma. ...Read more
Kidney biopsy shows the reason for kidney failure is multiple myeloma. No bone damage, hemo. More than 12. Will kimo therapy help to recover fully?
Seek opinion from a: This is unusual way to make a diagnosis of multiple myeloma(mm). Typically we need to do a bone marrow biopsy and look for cancer cells in the marrow. These cells produce abnormal proteins(m protein) which will show up either in the blood(commonly) or in the urine. We use a test called protein electrophoresis. If these tests have not been done, seek a second opinion. Chemo will help to control mm. ...Read more
It depends: Survival in myeloma depends on a number of factors. First, is stage. Second is chromosomal abnormalities. Some have a good prognosis, others not so good. In general we think that myeloma is not usually curable with standard therapies, but survival is getting better with our newer agents, so that living 10 years is not unusual. Cure may be possible with allogeneic bone marrow transplant. ...Read more
What is the current prognosis of african american women with multiple myeloma with renal failure?
Depends: This can best be answered by your treating physician. It often depends on age, other medical disorders, previous treatments, response to velcade (bortezomib). Most patients will have improvement in renal failure if this is the first treatment they receive, and the treatment usually includes velcade (bortezomib). ...Read more
58 Years old diagnosed with Stage IV colorectal cancer and spread to liver with 7+cm tumor and lesions in the lung. What kind of life expectancy?
It Depends: Recent progress in genetic typing of individual Colon Ca tumors and genetic specific tumor drugs is leading to better understanding of likelihood of treatment success. See: https://www.researchgate.net/profile/Arun_Azad/publication/246837094_Predicting_the_response_to_targeted_therapy_in_metastatic_colorectal_cancer/links/5419c4180cf2218008bf9f8a.pdf I recommend getting into a clinical trial. ...Read more
Labs, xrays: There are a series of blood and urine tests that will give the doctor a good idea if you have the disease. These are usually followed by x-rays looking for tell-tale signs of myeloma and a bone marrow test which would identify the cancer cells themselves. ...Read moreSee 1 more doctor answer
Pl suggest any alternative remedy/ies for multiple myeloma I am 48 yer old and no m band seen at this moment after 6 months of chemo?
Homeopathy, herbs ;: There are no proven alternatives for multiple myeloma but that does not mean they may not help; but i would continue standard treatments too. A healthy diet, tonifying herbs, reducing body burden of heavy metals ; other environmental toxins, stress reduction ; working to clear unresolved anger/grief etc. Can only help. I also advise classical homeopathy with a good homeopath. See comments for more:. ...Read moreSee 1 more doctor answer
Blood/Urine/Imaging: Usually workup involves blood and urine tests (spep / upep - serum and urine protein electrophoresis). The preferred initial imaging study is the skeletal survey (x-ray of multiple sites of the body including skull, axial skeleton, and proximal long bones). Bony lesions are usually lytic. ...Read moreSee 1 more doctor answer
The tests for Multiple myeloma include:: Albumin, Basic metabolic panel, Bone marrow biopsy, Complete blood count, Ionized calcium, Lactate dehydrogenase, MRI, Skeletal survey, C reactive protein, Protein electrophoresis, 24 hour urine protein electrophoresis, Free kappa lambda light chains, Beta 2 microglobulin. ...Read more
Plasma cell cancer: Multiple myeloma is a cancer of plasma cells (pcs). Pcs are the specialized b lymphocytes that produce antibodies. When there is a cancer or one (mono-) clone (= monoclonal, m) pc population they can product m-proteins. Symptoms include crab - hypercalcemia, renal (kidney) insufficiency, anemia, bone disease; also infection and pain. More: http://www.Cancer.Net/cancer-types/multiple-myeloma. ...Read more
None: If truly smoldering myeloma, there are no signs. If there are symptoms, then it may be myeloma. Hope this helps. ...Read more
See below: Treatment for multiple myeloma has improved markedly and drug treatment alone or drug treatment with auto or donor stem cell transplants can produce decades long remissions. See this site for more info. http://www.mayoclinic.org/diseases-conditions/multiple-myeloma/basics/definition/con-20026607 ...Read more
Depends: Myeloma has a variable natural history. Many patients have had myeloma for years prior to diagnosis without realizing it, while others are diagnosed by screening for monoclonal protein in the blood. Modern hematologists can use advanced treatments like velcade, revlimid, (lenalidomide) thalomid, and stem cell transplant, allowing myeloma patients to live longer than ever. More info: http://bit.Ly/lrzotm. ...Read moreSee 1 more doctor answer
Much better now: With all the new targeted drugs for myeloma and several to come, patients live many more years. Some have said this cancer is now more like a chronic disease - still dangerous and needing treatment but it is characterized by longer periods of remission after treatment. Therefore a 65 or 75 year old person may have a normal life span with this disease now. ...Read moreSee 1 more doctor answer
Simple answer is that it is a medical technology used primarily to provide an artificial replacement for lost kidney function in people with renal failure. Hemodialysis remove wastes and excess water from the blood by circulating blood outside the body through an external filter, called a dialyzer. Blood and dialysate flow through in opposite directions and the ...Read more
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