Doctor insights on:
Adult Low Grade Infiltrative Supratentorial Astrocytoma Oligodendroglioma
My 8 yr old nephew has been diagnosed with a low grade astrocytoma glioma. Will radiotherapy be considered as surgery is NT an option.? Prognosis.?
Maybe: Radiotherapy can be effective for low grade gliomas but also carries risks of long term side effects. These are usually greater the younger a child is when s/he has treatment. Because these tumors sometimes grow very slowly, we sometimes watch them for awhile and then treat when we see growth. Sometimes chemo will be given to slow down growth and delay XRT until the child is older. ...Read moreSee 1 more doctor answer
Astrocytoma is a tumor that is arising from a specific cell type in the central nervous system (brain or spine) that is called astrocyte. These are the cells that support the actual nerve cells (neurons). It is a common type of nervous system tumor, which has different types, benign to malignant. Treatment is tailored according to this as well ...Read more
Brain tumor: Low grade astroctyomas can have a very variable course as far as growth. These are tumors that need to be monitored and if growth is suspected then therapies such as chemotherapy or radiation therapy might need to be given. You should be followed by both a neurosurgeon and a oncologist who specializes in tumors of the brain. ...Read more
Why is pituitary adenoma infratentorial in adult tumors but craniopharyngioma is supratentorial in childhood?
Sella Turcica: The tentorium cerebelli separates the cerebellum from the cerebrum. Supratentorial means ABOVE the tentorium and Infratentorial means BELOW. The pituitary gland sits in a special area called the hypophyseal fossa or sella turcia which is technically neither. Craniopharyngioma and pituitary adenoma grow SUPRATENTORIALLY in almost all cases, but rarely invade the clivus into the posterior fossa. ...Read more
Yes: Oligodendrogliomas are best treated with surgery. If there is a recurrence, or if the entire tumor cannot be removed, radiation therapy is usually used. Temozolomide is definitely an option for treatment if surgery and radiation have not been completely successful. Certain genetic mutations, if present in the oligodendroglioma, make it more likely that temozolomide will be effective. ...Read more
Astrocytoma: Astrocytomas are graded in one system from i to iii and in another system i to IV - in either case a grade ii means the tumor has some atypical looking cells but not obvious malignancy, there are however closely followed for any potential change. ...Read more
Yes: In general, only 25% of people are alive at 5 years with this diagnosis. However, there are many subsets that do better, and we still have not figured out completely why some patients do better than others. I would recommend pursuing treatment because some people do beat grade 3 astrocytoma, and likely treatments will only become more effective in the future. ...Read moreSee 2 more doctor answers
Manageable: I would not expect a cure, but the patient may have several more good years and there is the possibility of a breakthrough. ...Read more
What is the general prognosis for a grade 3 Astrocytoma and rate of recurrence with modern day diagnosis?
Astrocytoma: It depends. Ask your oncologist. Get asap if you don't have one. Sometimes they respond to new chemotherpay agents. Some are resectable, some respond to radiation. ...Read more
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