Doctor insights on:
Adriamycin Cytoxan And Taxol
Had an ultrasound that showed the liver to be slightly heterogeneous. Can that be due to past chemo therapy with Adriamycin, (doxorubicin) Cytoxan and Taxol?
Hx ILC, tx high dose Adriamycin/Cytoxan 2006. Now, fatigue, difficult swallow, CT scan = one tonsil & lymph nodes in neck enlarged. Risk lymphoma?
Was on Taxol and didn't work now going on doxil (liposomal doxorubicin) is that......Going to help?
Can you tell me about the long term side effects from the chemotherapy drugs adriamycin (doxorubicin) and cytoxin?
TWO MAJOR ONES: Adriamycin (doxorubicin) and Cytoxan is a great combination regimen used in breast cancer. The major long term side effects for both of these drugs is secondary leukemias, risk is around 1%. For adriamycin (doxorubicin) there is a concern for cardiotoxicity, but risk rises with cumulative dose. Risk is less than 10%. Patients get an echocardiogram or muga scan prior to therapy to evaluate heart status. Talk to your md. ...Read moreSee 1 more doctor answer
Half lives: For Taxol, the half-life is dependent upon the length of the infusion. If it is a three hour infusion, the half-life is approximately 24 hours, but for a 24 hour infusion, it is about 52 hours. For carboplatin, the retention half life can be as much as 30 hours. Hope that helps. ...Read more
Cyclophosphamide: "“Cyclophosphamide is contraindicated in patients who have a history of severe hypersensitivity reactions to it, any of its metabolites, or to other components of the product. Possible cross-sensitivity with other alkylating agents can occur. Cyclophosphamide is contraindicated in patients with urinary outflow obstruction.” See: http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=591d9955-3d9 ...Read more
Not too many: Taxol (paclitaxel) is contraindicated in patients who have a history of hypersensitivity reactions to Taxol (paclitaxel) or other drugs made in cremophor el (polyoxyethylated castor oil). Taxol (paclitaxel) also should not be used in patients with solid tumors who have white counts of less than 1500 cells/mm3 or in patients with aids-related kaposi’s sarcoma with baseline white counts of less than 1000 cells/mm3. ...Read moreSee 1 more doctor answer
Good, but....: PredForte is considered first line. Serious uveitis is best treated the Himira or Enbrel (etanercept) like TNF-alpha inhibitors. Cyclophosphamide works as do other immunosuppressants! Keep in mind that chronic, recurrent uveitis can lead to glaucoma and is associated with a number of rheumatic diseases: sarcoidosis, spondylitis, Reiter's, psoriatic arthritis, etc! ...Read more
It can: It can- but that will depend on the cumulative dose given, your age when receiving the treatment, whether you also received other kind of therapy? Radiation etc. Please discuss your situation with your oncologist. ...Read more
Tell us more about y: Please give us some background about your question. Adriamycin is a very effective drug and is widely used in oncology. It does have some serious side effects but they can be manged quite well except for Hair loss. It can cause nausea and vomiting(but it can be easily controlled with anti-nausea medication. It can also affect the heart but your oncologist will take due precuations ...Read more
Not a standard treat: Cytoxan (cyclophosphamide) and 5-fu jused to be used as first line chemo for breast cancer, but there are much more effacious drugs available now. I would not use these drugs now as first line treatment fofr anything except in special circumstances. ...Read moreSee 1 more doctor answer
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