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Doctor insights on: Adrenal Estrogen

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Classical adrenal hyperplasia, estrogen pill at age 18 and got 1st period, now stopped pill so no period for 4 yrs .I am 26 yrs want to conceive.Help.

Classical adrenal hyperplasia, estrogen pill at age 18 and got 1st period, now stopped pill so no period for 4 yrs .I am 26 yrs want to conceive.Help.

SPECIALIST: You really need to see a fertility specialist. First you need to make sure you have all the correct genetic testing of you and your partner. You would need to discuss how to manage treatment to prevent problems to the baby them self and how to go about treatment. ...Read more

Estrogen (Definition)

Estrogen is a hormone that is secreted by the ovaries and affects ovulation, ...Read more


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In context of cryofibrinogenemia, lupus-type ctd and adrenal insufficiency, what could cause increase in GI symptoms, nausea, and vomiting with adrenal crisis, when estrogen/progestin drugs are taken?

In context of cryofibrinogenemia, lupus-type ctd and adrenal insufficiency, what could cause increase in GI symptoms, nausea, and vomiting with adrenal crisis, when estrogen/progestin drugs are taken?

Cortisol deficiency : With true adrenal insufficiency diagnosed by an endocrinologist, one would need to be taking cortisol replacement therapy. Nausea, abdominal pain, vomiting and weight loss are classic symptoms of adrenal insufficiency which estrogen and Progesterone replacement don't address. Many with primary adrenal insufficiency also look like they have a deep tan. ...Read more

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Do women with addison's adrenal insufficiency have low estrogen ?

Not significantly: The adrenal glands produce hormones which are precursors to estrogen, but that only comprises a small amount relative to what the ovaries make. Ovaries are the source of most estrogen in females. If menstrual cycles are irregular in properly treated addison's disease, autoimmune disease of the ovaries may need to be considered also. ...Read more

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What effect will having an adrenal tumor that produces a lot of estrogen have on a female's growth if left untreated?

Take it out: It needs to come out - really rare and potentially malignant. High estrogen levels still increases risk for other cancers, particularly breast and endometrial. Additionally, for the girl, sexual maturity comes quickly, growth will be stunted due to acceleration of growth plate maturity leading to premature closure. Infertiility and other problems. ...Read more

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Do women with addison's disease/adrenal insufficiency also suffer from low estrogen ?

Do women with addison's disease/adrenal insufficiency also suffer from low estrogen ?

Not necessarily : If you are a post menopausal female your adrenal glands are providing your only source of estrogen. So if you have low adrenal function you could most certainly have low estrogen. However, you may also then have other low hormone levels like Progesterone and testosterone. The truth is most women do not suffer from low estrogen, you need very little but they frequently suffer from low progesterone. ...Read more

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What causes low blood level of dhea. I'm 25 female. Adrenal tumor maybe? I have high estrogen and chronic fatigue, body pain etc...

What causes low blood level of dhea. I'm 25 female. Adrenal tumor maybe? I have high estrogen and chronic fatigue, body pain etc...

See endocrinologist: Dhea isn't a hormone we typically measure at random because it isn't as reliable as the longer 1/2 life of dheas. Likewise, we usually don't measure total estrogen as it isn't helpful. Dhea is most reliable when compared before and after IV acth during stim testing around other hormones. Adrenal insufficiency can't be identified with a random dhea. ...Read more

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Can adrenal fatigue cause low grade fever? Are progesterone and estrogen levels related to adrenalin and cortisol?

Can adrenal fatigue cause low grade fever? Are progesterone and estrogen levels related to adrenalin and cortisol?

Dubious diagnosis: "adrenal fatigue" is a pop diagnosis, not an evidence-based one. Since true addison[s isn't a febrile illness, this isn't either. I've wondered if the "subclinical addison's" claims might have something to them, but would urge you not to self-diagnose. The danger of self-diagnosis / treatment is missing another real emotional, situational or physical problem. Your doctor should work your temp up. ...Read more

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With isolated adrenal insufficiency likely due to LH and crest with digital ischemia, is estrogen/progesterone supplement needed to protect bones (estradiol < 20) given daily cortisol supp of 20-30mg?

See below: If you are corticosteriods for a long period of time, you do need to be medications to protect your bones. Besides hormones, you could go a class of drugs known as bisphosphonates. Talk to your doctor about your options. ...Read more

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What pituitary hormones cause the adrenal gland to produce mineralocorticoids, glucocorticoids, and androgens and estrogens including pregnenolone?

What pituitary hormones cause the adrenal gland to produce mineralocorticoids, glucocorticoids, and androgens and estrogens including pregnenolone?

Pituitary & steroids: Hi. Pituitary ACTH regulates adrenal cortisol production; it also acutely stimulates aldosterone, but is not the principle regulator. LH principally stimulates gonadal steroid hormone production (both genders make androgens & estrogens, but in opposite dominance). Pregnenolone is early in the steroidogenic pathway in both adrenals and gonads. Good luck! ...Read more