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Doctor insights on: Adenocarcinoma With Neuroendocrine Differentiation

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Are carcinoid tumors carcinoma? Is malignant metastatic stomach carcinoma that's hereditary a carcinoid cancer? carcinoid Neuroendocrine tumors?

Are carcinoid tumors carcinoma? Is malignant metastatic stomach carcinoma that's hereditary a carcinoid cancer? carcinoid Neuroendocrine tumors?

Complicated question: Carcinoids are carcinomas, usually more slow growing than adenocarcinomas. For information in this topic you may consult this link: http://www.webmd.com/cancer/carcinoid-tumors#1 ...Read more

Dr. Riley Alexander
130 doctors shared insights

Adenocarcinoma (Definition)

Adenocarcinomas arise from glandular or secretory tissues. They are the common type of tumors (as opposed to sarcomas, from connective tissue) and include the common types colon, lung, ...Read more


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What characterizes early stage squamous cell carcinoma?

What characterizes early stage squamous cell carcinoma?

Nothing: Even in the lung, squamous cell carcinomas are usually silent until they have become large enough to cause coughing up of blood -- one of the common ways in which it announces itself. On the skin, of course, a growing mass with a rough surface is (depending on how it looks) likely to be a squamous skin cancer; these are usually easy to cure. Good luck. ...Read more

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Colon biopsy:huge tubulovillous adenoma with marked atypia, multi foci adenocarcinoma in situ &one tiny focus suggestive of micro invasion.Is it cancer?

Colon biopsy:huge tubulovillous adenoma with marked atypia, multi foci adenocarcinoma in situ &one tiny focus suggestive of micro invasion.Is it cancer?

Yes: Adenocarcinoma in situ is cancer. The area suggestive of micro invasion suggests you should have rather aggressive followup screening which I am sure your doctor has, or will soon suggest. Stay on top of this and follow his/her advice. ...Read more

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What causes ductal carcinoma in situ (dcis)?

What causes ductal carcinoma in situ (dcis)?

Viral insertion: DCIS is the earliest phase of transformation to malignancy developing in the ductal system before invasion into parenchyma has occurred. It is defined on mammo by clustered microcalcification. In general the long terminal repeat of the MMTV viral genome enters the ductal cell to initiate transformation. with time the cells become aggressive and invade basement membrane helped by the EBV virus ...Read more

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Is metastatic squamous cell carcinoma genetic?

Is metastatic squamous cell carcinoma genetic?

Genetic component?: There could be genetic component to a squamous cell cancer, although the exact implications on treatment aren't known. Obviously if there is a strong family history of cancers, or if it strikes someone who is young and/or a non smoker/drinker i would suspect a strong genetic contribution. Without more details, it is hard to say with any certainty. ...Read more

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What is the prognosis with bronchogenic carcinoma and brain metastasis newly diagnosed?

What is the prognosis with bronchogenic carcinoma and brain metastasis newly diagnosed?

Prognosis: Unfortunately to present with a new lung cancer with brain metastasis generally carries a poor prognosis with median survival generally measured in few months. Survival prediction is always difficult and has a lot to do with 'performance status', ie how well a patient is carrying on with activities of daily living. Specific cell type, size of tumor, extent of metastasis in brain and elsewhere. ...Read more

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What is poorly differentiated squamous cell cancer?

Very malignnt.: This is a kind of squamous cancer that is poorly organized, or has no resemblance to what squamous lining should look like. It follows that this is a very serious cancer that must be treated very aggressively for any chance of a favorable outcome. ...Read more

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Invasive non keratinizing squamous cell carcinoma tongue showing nests of malignant squamous cells grade 3 prognosis?

Invasive non keratinizing squamous cell carcinoma tongue showing nests of malignant squamous cells grade 3 prognosis?

Can be cured: If no nodes palpable and lesion localized, RT chemo can reduce size and position site for curative resection. Partial glossectomy after initial therapy. If larger and not responsive to chemo, Ive used hight dose MTX with citrovorum factor over 12 hrs. Most effective in presence of nodal disease Basic chemo is Platinum/Taxol + RT ...Read more

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Metastatic carcinoma omental tissue with unknown source men?

Metastatic carcinoma omental tissue with unknown source men?

Unfortunate: This is usually an unfortunate situation. The most common primary site will be somewhere in the intestinal tract, like the stomach. The pathologists will try many stains on the tissue to help define the origin. This helps with choosing the most appropriate chemotherapy. ...Read more

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Is infiltrative basal cell carcinoma an aggressive cancer?

Is infiltrative basal cell carcinoma an aggressive cancer?

Can Be: Usually basal cell carcinoma tend to be less aggressive than some other types of skin cancers. Here is a good resource for more on the topic http://www.Cancer.Net/cancer-types/skin-cancer-non-melanoma. ...Read more

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What are the chances of metastatic renal cell cancer in a nephrectomised patient with clear cell carcinoma (fuhrman grade 2)?

What are the chances of metastatic renal cell cancer in a nephrectomised patient with clear cell carcinoma (fuhrman grade 2)?

Need more info: Stage and grade are needed to estimate this risk. One can check nomograms dot org where a number of such risk calculators can be accessed. ...Read more

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Prognosis for hormone refractory metastatic prostate cancer with pathological fracture?

Prognosis for hormone refractory metastatic prostate cancer with pathological fracture?

Prostate cancer: This is an advanced stage of prostate cancer; the good news is there are many new drugs and treatments for men in this stage that have been shown to extend life; in this stage survival is extremely variable from months to years isn't impossible. ...Read more

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Is renal cell carcinoma stage 4 an aggressive cancer?

Is renal cell carcinoma stage 4 an aggressive cancer?

Stage 4 : Stage 4 renal cell carcinoma usually means that the cancer has spread to other parts of the body. At this stage, the cancer is consider very aggressive. www.peedoc.com @drhtay. ...Read more

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What is mucin-producing metastatic colonic adenocarcinoma?

Subtype of colon Ca: Mucin producing metastatic adenoca of the colon is derived from a primary adenoCa of colon producing large amounts of extracelluar mucin with greater than a 50% mucinous component.. The proximal colon and appendix represents 10-20% of these colorectal neoplasms . The rt. colon is the usual source for most of these lesions presenting with more advanced forms of disease than other colonic sites. ...Read more

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Colon surgery:tumor size=2cm.Pathologic staging(pt3, n1b, mx).2/17 lymph nodes show metastatic.Margins of resection free of carcinoma.Need chemotherapy?

Colon surgery:tumor size=2cm.Pathologic staging(pt3, n1b, mx).2/17 lymph nodes show metastatic.Margins of resection free of carcinoma.Need chemotherapy?

Yes: Chemotherapy regimens based on the drug Fluorouracil (5-fu) have been part of the treatment for high-risk stage ii or stage iii colon cancer. Many clinical trials have shown that these regimens improve overall survival primarily by reducing the high risk of recurrence within the first two years after surgery. ...Read more

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How are carcinoma in situ and benign neoplasm different?

Good question: And difficult to tell sometimes. The most straightforward way to put it is that a benign neoplasm will never turn into an invasive malignancy within your lifetime. Cis will eventually turn into one. But, because we don't live forever, cis might not turn into a malignancy during one's lifetime anyway. Pathologists can usually, but not always, tell the difference by microscopic cell exam. ...Read more

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Hepatocellular carcinoma.All spleen and partial liver resection.Later,secondary systemic cancer metastasis.any targeted therapy or immunotherapy?

Hepatocellular carcinoma.All spleen and partial liver resection.Later,secondary systemic cancer metastasis.any targeted therapy or immunotherapy?

Yes, for both: Hepatocellular Carcinoma is commonly treated with Sorafenib which is a type of targeted therapy. This is a good choice of treatment in case you have not yet received this drug. Immunotherapy using PD-1 inhibitors has also shown some modest evidence of benefit although it is not yet FDA approved for this indication. Ask your oncologist to guide your treatment further. ...Read more

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What is adenocarcinoma, moderately differentiated mean?

It is cancer: Adenocarcinoma is a cancer that originates from glandular epithelial cells. This is usually classified as poorly, moderately or well differentiated based on the resemblance of these cells to normal epithelium with the well-differentiated cells being most similar in appearance to the normal cells. The poorer the differentiation, the more aggressive and poorer prognosis. ...Read more

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What is differentiated adenocarcinoma endometrium?

Cancer of the uterus: This is a medical expression used when doctors report a diagnosis of Cancer of the Uterus lining(endometrium). Your gynecologist can explain further, so call him/her up ASAP and ask how to get this disease treated soon. ...Read more

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What has to be performed in order for the results to show a moderately differentiated adenocarcinoma?

Biopsy: but that result is a simple biopsy, making regular slides and regular coloring of it and looking under the microscope. Identical technology from the 19th century. ...Read more

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Is it possible for differentiated endometrioid adenocarcinoma to be cured?

Yes: endometrial cancer which begins in the endometrial mucosa, before invading myometrium or muscle of uterus is virtually 100% cureable. Even if D&C shows tumor cells spreading to blood stream this is not metastasis but cells pushed by curettage into the blood. Even early muscle invasion followed by hysterectomy with node diss. can be cured. ...Read more

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What's the option for a patient diagnosed with poorly differentiated adenocarcinomas with mixed inflammation?

Options for Cancer: Need more information, such as where is it located (adenocarcinomas can be in many different organs), is there lymph node involvement, etc Important to remember that there is alway more than one option or approach, including choosing not to treat. Talk it over thoroughly with your oncologist, ask lots of questions, have someone with you to take notes, get 2nd (and 3rd) opinions if necessary. GL ...Read more

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What can be done for poorly differentiated adenocarcinoma arising in the setting of intestinal metaplasia?

CUP?: Cancer 1-2-3 -- 1) diagnosis -- we know cancer , but what kind? May need additional information -- is this a colon polyp, now cancer or what? Pathologist can help and may need special testing. 7% of cancers have know known primary (cup or upc). 2) staging and prognostic factors. 3) treatment. Need all of the pieces of the puzzle before treating. ...Read more

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The biopsy results says invasive moderately differentiated adenocarcinoma. Please what does this means and what is the medical cure for this?

What organ?: The report you described means cancer. The treatment depends on the stage of the tumor and organ affected. It is not an issue for self treatment, please see your doctor. ...Read more

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My husband was diagnosed with invasive moderately differentiated pulmonary adenocarcinoma. What is the course of treatment?

Your oncologist is t: Your oncologist should guide you in the decisions towards treatment. Cancer treatments are dictated by the stage of disease. So you need to know what stage of lung cancer he has. For early stages, surgery can be the best option but as it goes from stage 1 to 3, chemotherapy and radiotherapy are used in combination. For stage 4 it is mostly chemotherapy which is most useful. ...Read more

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Hello can u tell me what I do histopathology report : section show poorly differentiated mucinous adenocarcinoma with ulceration of mucosal surface?

Cancer: It is a subtype of cancer that arises from cell of the glands that produces some mucin/mucous. Where is this located? Colon? You need to discuss further re- treatment plan with your oncology team. Treatment and everything will depend on what kind of cancer is this? The stage? The molecular pattern/biology of the cancer? Your overall condition? Etc. Good luck. ...Read more

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64 YO female, biopse: ulcerated colonic mucosa with moderately differentiated adenocarcinoma ... what does it mean and is there a cure?

64 YO female, biopse: ulcerated colonic mucosa with moderately differentiated adenocarcinoma ... what does it mean and is there a cure?

Yes good out look: If localized has excellent prognosis , get it treated , follow your doctors advise , share your fears with your family and they will give you all the support you need and help you to pass this crisis. good Luck ...Read more

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My fil,68 yrs,biopsy report stating "well differentiated papillary adenocarcinoma" @ rectosigmoid junction. Dr suggests surgery -R we doing right ?

My fil,68 yrs,biopsy report stating "well differentiated papillary adenocarcinoma" @ rectosigmoid junction.  Dr suggests surgery  -R we doing right ?

Sounds right: With the limited information you have provided, it appears he has cancer of that portion of his colon. Surgery is usually the definitive treatment for such. Good luck. ...Read more

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My husband is diagnosed with poorly differentiated adenocarcinoma of the right lung with alk & egfr mutations; stage 3b what is the prognosis and life?

My husband is diagnosed with poorly differentiated adenocarcinoma of the right lung with alk & egfr mutations; stage 3b what is the prognosis and life?

Fair: It is extremely unusual to have both mutations. They are mutually exclusive. Patients that do carry one of these mutations are eligible for various medications that target these mutations. Crizonitib for alk and tarceva (erlotinib) for egfr and new agent recently to the market. These new finding have improved the prognosis. Other factors do enter in. Age, ps, smoking history if any, wt. Loss, etc. ...Read more

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30 year old female, stage iii-b well differentiated adenocarcinoma in sigmoid colon 4 lymph nodes affected was surgically removed. What's better xelox or folfox for chemo? And why?

30 year old female, stage iii-b well differentiated adenocarcinoma in sigmoid colon 4 lymph nodes affected was surgically removed. What's better xelox or folfox for chemo? And why?

Trust oncologist: 30 yr old stage iii b needs all that is needed to prevent recurrence , both drugs have oxaplatin , folfox has 5 fu & Folic Acid , xelox has Capecitabine , all comparative studies showed almost equal results, please rely and trust your oncologist advise , as therapies are changing so fast for good , will encourage if you want to take a second opinion good luck ...Read more

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Diagnosed Well Differentiated Endometrial Adenocarcinoma FIGO1and TVUS says significant thickening with hyperechoic nodule directly adjacent to endometrial cavity. Meaning? My biopsy was done by Pipelle. They never mentioned my Uterine fibroid I have

Adenoca/endometrium: A biopsy of the endometrium which reveals adenocarcinoma needs continuing evaluation and treatment. A uterine fibroid is generally a benign condition. See your healthcare provider who did the biopsy for next steps, which should include possible surgery. ...Read more

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Biopsy: "sigmoid colon, well differentiated adenocarcinoma, grade i" does this indicate that the tumor won't probably metastasize? Triphasic CT shows a lesion in the liver (1cm) as well.

Biopsy: "sigmoid colon, well differentiated adenocarcinoma, grade i" does this indicate that the tumor won't probably metastasize? Triphasic CT shows a lesion in the liver (1cm) as well.

Grade 1 is a good: Sign, but nothing is guaranteed. Need to further understand the liver lesion as well. Work with the medical team to put together the best treatment plan for the individual patient situation. ...Read more

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How fast do adenocarcinomas grow?

It varies: It depends on their organ of origin. Adenocarcinoma of breast is much different than one arising in the colon or in the lung. Sometimes we can not find their primary origin...So called adenocarcinoma of unknown primary(acup) which has once of the worst outcomes and it causes serious trouble in 4-6 months. If you can tell us your complete history, i can be more exact in my response. ...Read more