Doctor insights on:
Acute Myeloid Leukemia With Monocytic Differentiation
Different cell type: Leukemias typically originate when one of the white blood cell types starts multiplying out of control and preventing the normal cells from doing their job. There are many types of white blood cells and the subtype of leukemia or lymphoma or myeloma depends on which subtype is out of control. ...Read moreSee 1 more doctor answer
Also known as AML, acute myeloid leukemia is a cancer of the white blood cells (called myeloid) cells formed in bone marrow. It often occurs in late adult or elderly patients and has usually a short development phase (hence acute). Symptoms of AML include easy bleeding or bruising or tiny red flecks on the skin ("petechiae") from low platelets; pale skin, fatigue or shortness of breath from anemia (low red blood cells); or infections (from low numbers of ...Read more
AML is a cancer.....: Of the bone marrow (actually a group of cancers) whose precise causes are unknown, but about which we know considerable molecular detail and are learning more each day. The disease arises from the hematopoietic stem/progenitor cells in the bone marrow when these cells acquire mutations that allow them to escape controls on growth and apoptosis. Subtype info is found on the nci website. ...Read moreSee 2 more doctor answers
AML: AML is the most common acute leukemia in adults and accounts for approximately 80 % of cases in this group. In us and europe, the incidence has been stable at 3 to 5 cases per 100, 000 population. In contrast, AML accounts for less than 10 % of acute leukemias in children less than 10 years of age. ...Read more
Types of cells: White blood cells are different with different mechanisms to pretect body from infections. Acute myeloid leukemia arise from a type of white cells called myeloid series or neutophils, cut lymphoblastic leukemiaa arise from lymph type of white cells. These two types of leukemia have different treatments and the outcome or expectations are very different, none is better than the other in general. ...Read more
Marrow cancer: CML is a marrow malignancy characterized by excessive number of white blood cells with various degrees of maturation. Most CML patients have deficient number of red cells and platelets. CML responds dramatically to oral agents called tyrosine kinase inhibitors. Examples are Gleevec and Sprycel (dasatinib). ...Read more
Yes! AML can kill.: Acute myeloid leukemia can be very aggressive. Generally it is treated at major clinical centers with a lot of expertise in leukemia especially at first. AML is seen in both children and adults. I would recommend that if either you or a family member is diagnosed with this to seek out a center of excellence. ...Read moreSee 1 more doctor answer
Can Philadelphia chromosome positive Chronic Myeloid Leukemia turn into Pre-B-Acute Lymphoblastic Leukemia?
Bone marrow cancer: White blood cells live and grow in the bone marrow and enter the blood stream where they travel throughout the body to fight infection. If these cells become cancerous, they grow out of control choking out the normal blood cells in the bone marrow and leaving the person vulnerable to infection, bleeding and anemia because there are not enough normal cells. All ages get AML but usually younger. ...Read moreSee 1 more doctor answer
If a person has AML - acut emyeloid leukemia, what percent of blast would suggest acute myeloblastic leukemia?
Blasts in blood/marr: Blasts are made in the bone marrow. Normally they are under 5% of all the white cells. So a Blast count in the bone marrow over 6% raises the question of Acute leukemia. Anything >30% blast count confirms a diagnosis of acute leukemia. As the blast cell numbers increase in the marrow, Blasts start to appear in the peripheral blood. That is how Leukemia is first diagnosed. ...Read more
Symptomatology level of what would be the difference between acute myeloid leukemia and acute lymphoid leukemia?
AML vs. ALL: The symptoms of AML and all can be quite similar since both cause anemia (low red cells) and low platelets (which causes bruising and bleeding). In addition, they both cause an increased risk of various infections. AML is more likely to cause swollen gums and lumps on the skin. All is more likely to cause neurological symptoms since it can sometimes get into the brain or spinal fluid. ...Read moreSee 1 more doctor answer
Blood cancer: All is a form of leukemia which in turn is a form of cancer, more specifically blood and bone marrow cancer. The word "acute" means it progresses faster, as opposed to chronic cases that usually have a slower progression. The word "lymphoblastic" means immature lymphoid and describes the type of malignant cell involved in this leukemia, as opposed to other types of cells, for example myeloid. ...Read moreSee 3 more doctor answers
A blood cancer: CML is a blood cancer that develops slowly (hence chronic). If untreated it will eventually be life threatening. It is associated a unique chromosomal injury, the philadelphia chromosome. New drugs (tkis) target this damage and reliably produce remissions in early stage patients that often are long lasting. ...Read moreSee 1 more doctor answer
Differs depending...: On the subtype of all, age and risk stratification. Pts with b-cell phenotypes tend to do better than those with t-cell dz. Children tend to do better than adolescents and adults. There are also several molecular abnormalities with prognostic significance. Not enough room here to list. Taking all comers, survival among adults is 40-50% while for children, 80-85%. Ask if you need more specifics. ...Read moreSee 1 more doctor answer
I believe you have: These diagnoses confused. Chronic leukemias display an elevated # of wbcs with morphologic and functional features similar to the mature cells of that lineage (lymphoid-cll vs myeloid-cml). Think of it as not turning off the spigot when the bucket is full. Acute leukemias have features of immature cells for a lineage (aml vs all). Acute leukemias can arise from chronic ones. This is blast crisis. ...Read moreSee 2 more doctor answers
Different cells: Myeloid cells and cancer (eg, aml, cml) are different than lymphoid cells and cancer (eg, all, cll). Just as breast cancer and colon cancer are different. Of course they are bone marrow cancers with blood cells and the differences are not like the solid tumor differences i mentioned above. The disease course and treatments are different based on the diagnosis and other factors. ...Read moreSee 1 more doctor answer
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