Doctor insights on:
Acute Myeloid Leukemia With Monocytic Differentiation
Yes! AML can kill.: Acute myeloid leukemia can be very aggressive. Generally it is treated at major clinical centers with a lot of expertise in leukemia especially at first. AML is seen in both children and adults. I would recommend that if either you or a family member is diagnosed with this to seek out a center of excellence. ...Read more
Also known as AML, acute myeloid leukemia is a cancer of the white blood cells (called myeloid) cells formed in bone marrow. It often occurs in late adult or elderly patients and has usually a short development phase (hence acute). Symptoms of AML include easy bleeding or bruising or tiny red flecks on the skin ("petechiae") from low platelets; pale skin, fatigue or shortness of breath from anemia (low red blood cells); or infections (from low numbers of ...Read more
See below...: Once a diagnosis of leukemia is made, a referral to a hematologist/oncologist is necessary. The oncologist will decide what the best treatment plan is and how to manage the condition. Immediate consultation with a hematologist/oncologist is of paramount importance for a favorable outcome. ...Read more
Fatigue, fever etc: Acute myeloid leukemia starts from bone marrow, where normal blood cells were made. Leukemia cells will decrease the abilities of bone marrow to make normal blood cells such red blood cells (delivery oxygen); white blood cells (fight for infection), and platelets (stop bleeding). Therefore, the symptoms can be fatigue, fever, bruising or bleeding, bone pain, swollen glands, and weight loss. ...Read more
Yes: Not the best scenario but it can occur. ...Read more
See below...: The treatment of leukemia, like any other cancer, should be managed by an oncologist. Many times the relapse is still responsive to chemotherapy and a second remission may be achieved. Subsequent options should be discussed with the oncologist and may include a bone marrow or stem cell transplant. ...Read more
Different cell type: Leukemias typically originate when one of the white blood cell types starts multiplying out of control and preventing the normal cells from doing their job. There are many types of white blood cells and the subtype of leukemia or lymphoma or myeloma depends on which subtype is out of control. ...Read more
Too many: Factors to make a specific comment. Without treatment survival is weeks to a few months. Many AML patients can be cured. ...Read more
Can you tell me more about getting acute myeloid leukemia due to using certain chemicals such as benzene?
See below: There have been cases where prolonged exposure to various chemicals increase the chance of leukemia and other varieties of cancers. The charnoble disaster in russia caused a significant increase in leukemias, lymphoma and other varieties of cancers in the population in chernoble and surrounding communities. ...Read more
The answers depend on patient age, overall health, and type of aml.
Usually younger, healthier patients are offered aggressive chemotherapy and possible stem cell transplant, while older patients are offered less aggressive chemotherapy or supportive care alone.
Here is a link to info on AML treatment:
http://www.Cancer.Gov/cancertopics/pdq/treatment/adultaml/patient/page1. ...Read more
AML is a cancer.....: Of the bone marrow (actually a group of cancers) whose precise causes are unknown, but about which we know considerable molecular detail and are learning more each day. The disease arises from the hematopoietic stem/progenitor cells in the bone marrow when these cells acquire mutations that allow them to escape controls on growth and apoptosis. Subtype info is found on the nci website. ...Read more
Bone marrow cancer: White blood cells live and grow in the bone marrow and enter the blood stream where they travel throughout the body to fight infection. If these cells become cancerous, they grow out of control choking out the normal blood cells in the bone marrow and leaving the person vulnerable to infection, bleeding and anemia because there are not enough normal cells. All ages get AML but usually younger. ...Read more
Marrow malignancy: AML is a bone marrow malignancy characterized by uncontrolled growth of leukemic cells in the bone marrow. It leads to very high white blood cell counts, anemia and thrombocytopenia (low platelets). It is rapidly fatal without prompt diagnosis and treatment. It can be cured in up to about 40% of people. ...Read more
It is really: Hard to tell accurately but it is pretty fast. As the name indicate, people with the condition are diagnosed when they develop one of the catastrophic symptoms. In general the development is pretty acute and progression is fast unless treated aggressively ...Read more
AML: AML is the most common acute leukemia in adults and accounts for approximately 80 % of cases in this group. In us and europe, the incidence has been stable at 3 to 5 cases per 100, 000 population. In contrast, AML accounts for less than 10 % of acute leukemias in children less than 10 years of age. ...Read more
MV-4-11: ...this is the name of a leukemia cell line used by cancer researchers. They originally came from a 10 year old boy with acute leukemia and they have the convenient property of being able to grow endlessly in a lab cell culture dish. Cancer researchers might use them for various purposes, such as testing new drugs, before trying them in people. ...Read more
Varies: Though this varies widely, the median survival is in the range of 6 weeks. ...Read more
Are certain groups more susceptible to acute myeloid leukemia? Do some groups experience this disease differently than others?
Chemotherapy: Acute myeloid leukemia is treated with chemotherapy. The type of drugs and intensity of the chemotherapy is determined by factors such as the patient's age, other medical problems and prior therapies. Chromosome changes in the leukemia cells can also determine the treatment given. A bone marrow or stem cell transplant is used in some cases. ...Read more
It involves Chemothe: Typical treatment for acute leukemia requires admission to the hospital for chemotherapy which can make you sick and cause infections. So, most patients end up in the hospital for several weeks to begin with till their leukemia goe sinto a remission which is early benefit of an effective chemotherpy which is the case in half to 2/3 of the cases. Young adults do much better than the old (>60 yrs). ...Read more
See below...: First of all, the treatment for any type of leukemia should be coordinated by a hematologist/oncologist. To answer your question, chemotherapy is usually the first line of treatment. There are certain types of chronic leukemia that progress very slowly and do not need treatment initially. After chemo, remission or even cure may be achieved. The next step may be a bone marrow transplant. ...Read more
A malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more