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Doctor insights on: Acute Lymphocytic Leukemia

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What is a karyotype for acute lymphocytic leukemia?

What is a karyotype for acute lymphocytic leukemia?

A karyotype is ...: A technique that lets us see the gross structural features of the chromosomes in a cell. Cells are forced to enter mitosis but then are arrested in metaphase with a drug called nocodazole. The chromosomes can the be seen under the microscop which lets is see their number and structure. All cells can have multiple abnormalities that can be seen by karyotype, but may be normal as well. ...Read more

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Dr. Liawaty Ho
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Leukemia (Definition)

A malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more


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Is there a karyotype for acute lymphocytic leukemia?

Is there a karyotype for acute lymphocytic leukemia?

Yes: Chromosomal abnormalities, such as t(9;22)(q34;q11) (abl/bcr), t(12;21)(p13;q22) (tel/aml1), and t(11q23) (mll) are independent prognostic indicators in childhood acute lymphoblastic leukemia. ...Read more

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Help! what is acute lymphocytic leukemia in a chronic stage?

Help! what is acute lymphocytic leukemia in a chronic stage?

I believe you have: These diagnoses confused. Chronic leukemias display an elevated # of wbcs with morphologic and functional features similar to the mature cells of that lineage (lymphoid-cll vs myeloid-cml). Think of it as not turning off the spigot when the bucket is full. Acute leukemias have features of immature cells for a lineage (aml vs all). Acute leukemias can arise from chronic ones. This is blast crisis. ...Read more

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How rare is it for a child to have acute lymphocytic leukemia?

How rare is it for a child to have acute lymphocytic leukemia?

2.8/100,000: Acute leukemia is the most common form of cancer in children, comprises approximately 30% of all childhood malignancies, with acute lymphoblastic leukemia being 5 times more common than acute myeloid leukemia. Approximately 2500 to 3500 new cases of all are diagnosed in children each year in the United States with an incidence of 2.8 cases per 100, 000. ...Read more

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How frequently can relapse occur in acute lymphocytic leukemia (all)?

How frequently can relapse occur in acute lymphocytic leukemia (all)?

20-30: It depend to the type of ALL ,B cell ,T cell ,age of diagnosis ,bellow 2 years or above 9 years ,CNS involvement at diagnosis,but about 20-25% ...Read more

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My friend found out she has acute lymphocytic leukemia today. What can she expect?

My friend found out she has acute lymphocytic leukemia today. What can she expect?

Chemotherapy: All is generally curable in children, less so in adults. See this site for more info. http://www.mayoclinic.com/health/acute-lymphocytic-leukemia/ds00558. ...Read more

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Can there be a set karyotype for acute lymphocytic leukemia?

No. : Gross structural changes in chromosome number and structure can be identified by karyotype. There are many such changes associated with all development, yet many all patients have normal karyotypes. This doesn't mean mutations are absent. Modern techniques let us see changes across the genome at single nucleotide resolution. The critical role of epigenetic change is now also firmly established. ...Read more

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Please describe the mortality rate for acute lymphocytic leukemia?

Please describe the mortality rate for acute lymphocytic leukemia?

Differs depending...: On the subtype of all, age and risk stratification. Pts with b-cell phenotypes tend to do better than those with t-cell dz. Children tend to do better than adolescents and adults. There are also several molecular abnormalities with prognostic significance. Not enough room here to list. Taking all comers, survival among adults is 40-50% while for children, 80-85%. Ask if you need more specifics. ...Read more

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If a child has acute lymphocytic leukemia, can he continue with regular schooling?

If a child has acute lymphocytic leukemia, can he continue with regular schooling?

Interrupted: The regular schooling will be interrupted for several months to a year perhaps or could be a bit longer sometimes- while receiving chemotherapy and +/- if transplantation is required. After everything is completed and if complete cure is achieved- and no major complication from the treatment, he should/would be able to resume regular schooling. ...Read more

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How is the blood affected in a patient with acute lymphocytic leukemia?

How is the blood affected in a patient with acute lymphocytic leukemia?

Different ways: Although the word leukemia refers to cancerous white cells in the blood, many times the disease is growing so fast in the bone marrow that these cells never enter the blood and also, since they crowd out normal blood cells in the marrow, these are also decreased or absent in the blood leading to problems with infection, bleeding profound weakness. ...Read more

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What is happening in the blood in a patient with acute lymphocytic leukemia?

What is happening in the blood in a patient with acute lymphocytic leukemia?

Blood abnormal: The lymphoblast count (leukemic cells) increases, anemia and thrombocytopenia (low platelets) develop. This is all due to uncontrolled proliferation of lymphoblasts in the bone marrow. Rapid treatment is required. ...Read more

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Could you tell me what happens in the blood in a patient with acute lymphocytic leukemia?

Could you tell me what happens in the blood in a patient with acute lymphocytic leukemia?

See below...: Usually the WBC (white blood cell) count is significantly increased and continues to increase if the leukemia is left untreated. Anemia (low rbc count and hemoglobin) and thrombocytopenia (low platelets) are also common findings. The leukemic cells traveling in the blood may infiltrate various organs. Very high WBC counts may cause increased viscosity of the blood resulting in thrombosis (clot). ...Read more

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What is the difference between acute myeloid leukemia vs acute lymphocytic leukemia?

What is the difference between acute myeloid leukemia vs acute lymphocytic leukemia?

Types of cells: White blood cells are different with different mechanisms to pretect body from infections. Acute myeloid leukemia arise from a type of white cells called myeloid series or neutophils, cut lymphoblastic leukemiaa arise from lymph type of white cells. These two types of leukemia have different treatments and the outcome or expectations are very different, none is better than the other in general. ...Read more

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My baby girl was diagnosed with acute lymphocytic leukemia in 2006, and now he is diagnosed w/ aml. Is this possible?

My baby girl was diagnosed with acute lymphocytic leukemia in 2006, and now he is diagnosed w/ aml. Is this possible?

Very sad but..: This is a terrible situation. Unfortunately sometimes the treatment for acute lymphocytic leukemia can lead to damage of the normal bone marrow cells and lead to a secondary AML (acute myeloid leukemia). It sounds like that may have happened in this case. So sorry to hear this. ...Read more

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If a young child is diagnosed with acute lymphocytic leukemia why is the infection a problem when her WBC is counted?

If a young child is diagnosed with acute lymphocytic leukemia why is the infection a problem when her WBC is counted?

ALL infection risk: Patients with leukemia are at risk for life threatening infections throughout their treatment. At diagnosis, the WBC count may be low, normal or high, but regardless, the wbcs they have are the leukemia cells, which have not matured enough to work properly. Plus the marrow infiltration can prevent other types of wbcs from being produced. Drugs we use to treat leukemia also suppress immune function. ...Read more

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What sort of problem is acute non-lymphocytic leukemia (a.N.L.L.)?

What sort of problem is acute non-lymphocytic leukemia (a.N.L.L.)?

AML: Acute myelogenous leukemia (AML) is a type of leukemia that usually present relatively rapidly, but in some cases may have a longer development phase. It may be preceded by mds. Treatment is often stratified by age and co-morbidities but can include intensive chemotherapies and allogeneic stem cell transplant. ...Read more

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What are the diagnostic tests for acute lymphoblastic leukemia?

What are the diagnostic tests for acute lymphoblastic leukemia?

Bone marrow biopsy : The diagnosis is typically with a bone marrow biopsy, cytogenetics (dna of leukemia cells), and flow cytometry (cell surface markers of leukemia cells). ...Read more

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Could you tell me about acute lymphoblastic leukemia in children?

Could you tell me about acute lymphoblastic leukemia in children?

See below: It is a blood cancer in children. With advances in the treatment the prognosis has improved quite a bit. It used to be universally fatal disease about 15 years ago but now most children survive and get cured. ...Read more

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How typical is acute lymphoblastic leukemia in children in canada?

How typical is acute lymphoblastic leukemia in children in canada?

See below: Between 2003-2007, 1257 children (age 0-19 years old) were diagnosed with acute lymphoblastic leukemia in canada. See the following website for more information about statistics in canada: http://www.Cancer.Ca/en/cancer-information/cancer-type/leukemia-childhood/statistics/?Region=on. ...Read more

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What are are the different protocols for acute lymphoblastic leukemia?

Here are some links: This is an excellent site maintained by a heme-onc fellow on the east coast, and he has collected a few regimens for all. It's pretty tough to actually find a public site with this info: http://hemonc.Org/wiki/acute_lymphocytic_leukemia hope that helped you. Good luck. ...Read more

Dr. Michael Engel
55 doctors shared insights

Acute Lymphoblastic Leukemia (Definition)

Also known as acute lymphocytic leukemia, it is a cancer of the white blood cells. It occurs when there is an overproduction of immature white blood cells called lymphoblasts ...Read more