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Doctor insights on: Acute Intermittent Porphyria Diagnosis

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Differential diagnosis for acute appendicitis?

Differential diagnosis for acute appendicitis?

RLQ Pain: Long list including diverticulitis, crohn's disease, pelvic inflammatory disease, cholecystitis(gallbladder), ovarian cyst or twisted ovary, colon cancer, kidney stone, perforated ulcer, pancreatitis, bacterial infection and urinary tract infection to name a few. ...Read more

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Dr. Aletha Tippett
93 doctors shared insights

Porphyria (Definition)

A group of rare hereditary conditions involving abnormal metabolism of heme. A common form, Porphyria cutanea tarda affects the skin, with blisters, itching and rash that are worse after sun exposure. In Acute Intermittent Porphyria, abdominal pain, muscle pain, numbness or tingling, seizures, and ...Read more


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What are the differences between porphyria and aip (acute intermittent porphyria)?

Classification: Porphyria is a general term for a host of conditions, and acute intermittent porphyria is a variety of a more common variation in this disease category. ...Read more

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Why does acute intermittent porphyria (aip) sometimes cause abdominal pain?

Why does acute intermittent porphyria (aip) sometimes cause abdominal pain?

AIP attacks: Summarized in the following link: https://www.isitaip.com/patient/common-symptoms-of-aip?gclid=CjwKEAjwse7JBRCJ576SqoD7lCkSJABF-bKuavsrIeqpmL2IbvtWeLN7qn1yRJPDCXD3KZWVAwA98xoC-Jfw_wcB

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How is acute porphyria diagnosed usually?

How is acute porphyria diagnosed usually?

Urine PBG: Porphobilinogen. It's a test fraught with pitfalls and if the specimen isn't collected exactly right, you'll get a false negative. A few variants require other assays. ...Read more

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Can acute intermittent porphyria cause mental illness or psychosis?

Can acute intermittent porphyria cause mental illness or psychosis?

Short answer- YES: The diagnosis of AIP should always be in the differential diagnosis of a person who becomes psychotic& who fits a certain clinical profile which usually includes vague GI symptoms and abdominal pain unexplained neuropathy, and other characteristic symptoms. Feel free to write me more questions on this topic and I'll be happy to answer: www.healthtap.com/drsaghafi ...Read more

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In regards to acute intermittent porphyria, what causes abdominal pain?

In regards to acute intermittent porphyria, what causes abdominal pain?

Great question: AIP causes an axonal neuropathy which starts in proximal arms but spreads throughout limbs, and likely throughout the body. During the cramping attacks, there is an increase in delta-aminolevulinic acid and porphobiilnogen which likely stimulates abnormal nerve activity within the gut. ...Read more

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What usually precedes acute glomerulonephritis?

What usually precedes acute glomerulonephritis?

Acute GN: Often acute glomerulonephritis happens after strep infection (skin or throat) i.e. Post strep gn, or an upper respiratory infection (iga nephropathy). Otherwise, there is not necessarily any preceding event. ...Read more

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Can men have acute porphyria?

Can men have acute porphyria?

Yes: Both men and women can have acute porphyria. However, attacks are more common in women because of hormonal changes that occur during the menstrual cycle. ...Read more

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How is acute porphyria usually treated?

How is acute porphyria usually treated?

Supportive care: Glucose and hematin derivatives can be used to manage the acute attacks. The key to treatment is patient education -- it's a lifetime of learning to avoid the triggers and becoming more familiar with the illness than a physician specialist. ...Read more

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Idiopathic recurrent acute mild chronic pancreatitis CURE ?

Idiopathic recurrent acute mild chronic pancreatitis CURE ?

Unknown.: Idiopathic means that we don't know why it happens. If we don't know why it happens then we cannot make any logical assumption as to how to cure it. Further information could be helpful. Are you diabetic? Are you overweight? What kind of diet do you have? You drink alcohol ever? Is there anything that you eat that seems to make it worse? Do you have high cholesterol or high triglycerides? ...Read more

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What is acute onset addinopathy?

What is acute onset addinopathy?

Adenapathy?: Swelling of the lymph nodes, most commonly th lymph nodes of the neck. ...Read more

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Are chronic and acute berylliosis different?

Are chronic and acute berylliosis different?

Sure: Just depends on symptoms and severity. See your doctor. ...Read more

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Treatment of acute pancreatitis?

Treatment of acute pancreatitis?

It depends: In acute pancreatitis the basic treatment is resting the pancreas, by limiting intake of food. Also you are given IV fluids and pain medication. If the pancreatitis becomes very severe you may need antibiotics and in rare circumstances surgery. The other thing that is done is investigating the cause in order to prevent future attacks. ...Read more

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What are the clinical manifestations for acute pyelonephritis?

Pain and fever: Severe flank or lower back or deep abdominal pain and tenderness. Usually accompanied by fever and symptoms of a UTI which are burning sensation with urination and frequent urination. Possible blood in urine. ...Read more

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Hows porphyria cutanea tarda diagnosed?

Hows porphyria cutanea tarda diagnosed?

See below: The preferred screening test for pct is a measurement of porphyrins in plasma. This can differentiate pct from variegate porphyria. The patterns of porphyrins in urine (predominately uroporphyrin and 7-carboxylate porphyrin) and feces (predominately isocoproporphyrin) help to confirm the diagnosis. The presence of an inherited deficiency of urod can be demonstrated by measuring the enzyme in rbcs. ...Read more