Doctor insights on:
Acute Chronic Leukemia
Various: Acute leukemia can lead to symptoms (bleeding, fever, infection, weakness) very quickly and requires treatment soon to avoid serious consequences including death. Chronic leukemias are more indolent may take awhile before causing symptoms often diagnose incidentally on a blood count. Treatment depends on the kind of leukemia: myeloid-treated soon to avoid becoming acute; lymphoid-could be watched. ...Read more
A malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more
Everything: Acute leukemia is presented with the presence of significant level of a very immature blood cells in the circulation and increase level in the bone marrow. It is a very agressive and life threatening. Without treatment people die within weeks and few months only. Chronic leukemia- is progressing slower than acute leukemia. Chronic leukemia can transform into acute leukemia sometimes. ...Read more
I'm just wondering, if you are diagnosed with a form of chronic leukemia can it change to an acute leukemia?
Yes, sometimes: There are two separate types of chronic leukemia;these go by the names CML and cll. They follow a separate course and can have a long course of disease. CML often ends up as acute leukemia (called blastic change which is a type of acute leukemia bearing poor survival once this transformation has taken place. Fortunately the risk of this happening is much reduced with the modern treatments for cml. ...Read more
What are pros cons of drug procrit (epoetin alfa) to treat 88 year-old man whose chronic leukemia is now becoming acute where he needs transfusions every two weeks?
Limited value: Procrit (epoetin alfa) is commonly used in patients with cancer. But it is not always effective as it helps to raise red cell counts (hb) in most pateints but takes 4-6 weeks before it has any visible benefit. A patient with acute leukemia has more urgent needs which are best met with a blood transfusion as needed. But his age is against him to achieve much benefit from anything further that can be done for him. ...Read moreSee 1 more doctor answer
What is success rate of using prednisone in treatment of 88 year-old man whose chronic leukemia is now becoming acute with transfusions every 2 weeks?
Not significant: I am sorry, but I don't think that by itself will work. I do not know what is the reason to give you Prednisone for acute leukemia. If that is given in conjunction to other kind of therapy-that would make more sense. Please discuss with your oncologist further. Dacogen (decitabine) is something you can consider ...Read more
Blood work etc: You would need at least- blood work. Imaging scan for abdomen would be needed in certain chronic leukemia (cml) to evaluate spleen or if there is other indication (such as presence of abdominal pain etc); a bone marrow biopsy will be needed in certain case of chronic leukemia. Please discuss further in detail with your hematologist/ oncologist. Read more at www.Cancer.Net ; www. Lls. Org. ...Read moreSee 1 more doctor answer
Wish I knew.: There is some evidence that excessive exposure to chemicals such as benzene may lead to an increased incidence of chronic myeloid leukemia, and excessive exposure to radiation has also been implicated. Cllhas been linked to pesticide exposure in some-but not all-studies. In animals, diseases like cll are usually caused by a virus. In practice a doctor rarely finds the cause of a patients leukemia. ...Read moreSee 1 more doctor answer
50% are asymptomatic: About half of patients with chronic leukemia have no symptoms and are discovered on a routine CBC (complete blood count) usually obtained for some other reason. When symptoms do occur, they may include fatigue or tiredness, swollen glands or lymph nodes, low grade fever or sweats that are persistent. More advanced symptoms can include, bleeding, bruising, anemia, enlarging belly or an infection. ...Read more
Visit med onc doctor: The best approach is to meet with a medical oncologist with experience and discuss the treatment options when the diagnosis is confirmed. There are specifical mutations that can be tested for to guide the therapy. It depends if you have CLL or CML type. The oncologist can order the genetic testing and discuss current treatment guidelines. Then you give treatment a shot and see how it works. ...Read more
Blood cancer: Leukemia is a cancer of the white blood cells and bone marrow is the site of the defect. Treatment and outcome depend on the type of leukemia and stage of the disease. Some leukemias may be curable with intensive therapy and may require bone marrow transplantation. ...Read moreSee 1 more doctor answer
Chronic leukemia: 2 big groups of chronic leukemia are- chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (cll). The chance of beating CML is very good as the response to daily tyrosine kinase inhibitor therapy is amazing and the remission rate is high. In cll, however, therapy usually won't be needed on diagnosis if there is no indication. Also, many times people die of something else and not due to cll. ...Read more
Varies: Majority cases are asymptomatic and the evaluation is started due to abnormal blood work. When the leukemia is more advanced - patient can become symptomatic-and can be presented with-anemia, low platelet level- bleeding, increase white blood counts, recurrent infections, fatigue/decrease energy level, fever/chils/night sweats, increase abdominal girth etc. Read more : www.Cancer.Net / www. Lls. Org. ...Read more
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