Doctor insights on:
Actoplus Met Medication
Investigational: NEO 102 is a monoclonal antibody, not what is usually meant by the word chemotherapy. It is the subject of ongoing clinical trials. Therefore, it is not yet known whether the drug is useful, harmful, or indifferent. In the U.S. it would only be available for subjects in a clinical trial. I suspect, but am not certain, that that is true in the U.K. Too. ...Read more
What's the prognosis for nsclc, st 4, mets,. Chemo stopped. Kras and tissue samples & new clin trial drug being discussed now. 10 mts diagnosed?
Hard to predict: Metastatic lung cancer as a whole has a history of poor long term survival. Unfortunately, the 5 yr survival is only about 10%. But this is dependent on many things including age and type of cancer. Also, some people's tumors respond differently to chemo. Your cancer specialist may be your best resource. ...Read more
Will avastin (bevacizumab) increase survival significantly for metastic colon cancer with liver mets?
Is it a risky drug
Slight benefit: Bevacizumab (Avastin (bevacizumab)) is one of those drugs that is extremely expensive and often has limited benefit. Patients with metastatic colon cancer who received Avastin (bevacizumab) plus chemotherapy lived 1-2 months longer on average than those receiving chemo only. Because it has marginal benefit but costs ~$30,000 the U.K. Health Service won't pay for it. It can cause skin rash, bleeding or wound healing problems. ...Read more
3 factors: The tumor must produce matrixmetalloproteinase (MMP) to allow entry into the blood stream. The MMP must breakdown -cadherin to small e cadherin for progression of tumor growth and new cells invading circulation must express a surface antigen that determins site of implantation. Ovary spread to omentum where TGF beta present, Colon to liver because matrix contains liver ferritin. ...Read more
Metastasis: A cancer begins in an organ (say the breast). If it gets into the blood stream or the lymphatic stream the cells can travel to other parts of the body where, in the right environment, they may settle and grow. This development of tumor growth far away from the original site is called a metastasis. ...Read more
Metastases from what: Assuming you mean SQUAMOUS CELL CARCINOMA, your question makes no sense without details. Does "multi" mean 3? More? How many? All at once or over some years? Are they in areas exposed to sun or radiation? Are they in anal or genital area? Do you have a transplant? On meds? What is your understanding of "METASTASIS"? Evaluation and treatment should be done by a skin specialist. ...Read more
Finished cardio rehab. Started with ef of 20 now 50. Lost 23lbs. Mets exercise tolerance went from 9.8 to 16.9. Good sign for future?
Different results: Metastasis arises from primary, the former being clonal and the primary, polyclonal. What spreads to a site such as liver or lung can only grow within that parenchyma and never spread elsewhere. The primary has multiple clones each only capable of spreading to a local site and growing there. Thus, primary should always be removed and met focal disease treated later for best survival. ...Read more
These are 2 options:
Xeloda (capecitabine) — is an oral chemotherapy drug that can be used for certain metastatic cancers alone or in combination with other chemotherapy drugs as palliative treatment.
Zometa — is used in a situation where cancer has spread to the bones. It's not chemotherapy but a bisphosphanate, a medication used to prevent further weakening of bones by cancer and prevent fractures.
In some situations both are given. ...Read more
Fundamental!: All living things need a blood supply to deliver food, water, and get rid of waste. A circulating cancer cell needs to evade detection, get out of the blood vessel, and establish that blood supply: angiogenesis!. All these actors under molecular control, and likely normal during in utero development. Cut off the blood supply, choke the tumor. ...Read more
Cancer spread. : Metastasis is the spread of cancer from the place that it formed to other organs in the body. This usually is a bad sign prognostically, indicating more aggressive behavior. Some cancers can metastasize early, and others rarely do. The "stage" of cancer is determined by multiple factors, depending on the type of cancer. The presence of metastases often means a higher stage, worse prognosis. ...Read more
That depends. : You ask a good question. I think it depends on where the tumor or mets are located. With a spinal tumor I would anticipate worsening pain with growth, but initially it could fluctuate. Mets could cause both fluctuating and worsening pain, again depending on location. I would suggest seeing a local practioner if you are having pain or discomfort that are related to either if those things. ...Read more
Depends: A stage IV cancer-although it is treatable, unfortunately it is an incurable disease in majority cases. Some cancer like testicular cancer, however, can still be cured even though the cancer already spread beyond the primary organ. Lymphoma's prognosis is better than solid ca. The prognosis really depends on the type, the biology of cancer and your respond to treatment, overall condition etc. ...Read more
One study showed a response rate of 40%. "Response" in this context, means the tumor shrunk. It is rare for tumors to disappear on regorafenib. Clinical benefit depends to a great extent on the overall fitness of the patient (performance status), extent of disease, and number of prior therapies.
Courage and faith, Marilyn994, and my best wishes for you. ...Read more
Yes and no: When mets develop and defined as a lesion in lung, liver etc it is a pure lesion composed of the cancer. Some nodues are metastatic lymph nodes where the node has been replaced to some degree by tumor. In other cases a nodule may be an associated inflammatory condition or a lesion replaced by fibrous tissue after a chem response. Bx is essential for determining diagnosis and significance. ...Read more
Liver mets: A tough question. I presume you are seeing your doctor on a regular basis. It is time to make another visit, check the status of your liver, and then discuss options. ...Read more
Liver and peritoneal mets for mcrc patient. What is approx survival
With chemo, oxyplatin and raltitrexed?
We can not guess:
We can not tell you what the approx. survival as we do not have all the information to make a comment on the approx. survival
You should discuss with your treating Oncologist
There are second and third line treatments as well which may change the course ...Read more
Local & systemic: Cancer in general has local symptoms that are the result of the physical presence of an abnormal mass: obstruction, destruction or compression of airways, ducts, nerves, bones etc. Cancer also has systemic effects such as weight loss and sometimes the production of hormone-like substances that mimic various endocrine disorders. All becomes worse with mets ...Read more
If I am going to take a nolvatex tablets for my breast canser I am going to take kilos? And if I don't take them I am going to have metastasis?
Most people do not: Gain weight. Benefits outweigh the side effects. Please take them. ...Read more
Staging: Breast cancer staging is described as t (tumor size), n (lymph node metastases) and m (metastases to sites like bone, lung, etc). In a simplified short answer: stage 0 is non-invasive breast cancer, stage 1 is no spread to lymph nodes, stage 2 and stage 3 has lymph node spread and larger tumors, and stage 4 would have metastases to other organs. ...Read more
Individual: While breast cancer is a scary illness for most people (men can get it too), each person experiences it individually. Having it extend to other parts of the body can make this much more frightening. Some people become depressed, anxious, and have difficulty sleeping. There may be need to resolve old emotional issues. Symptoms can also vary depending on where the mets are, such as in brain. ...Read more
Treadmilltest comment?11min;speed6, 7km/h;grade: 16%mets: 11.6hr:152bpm;145/90mmhg;target 83%;st 1.4 mm — av;st 2.6 mm in ii;v4: -1.1 v5: -1, 3 v6: -1.2
Incomplete : For me clinical information is more relevant than these numbers you give. Cardilogist who did your tests and has examined you and knows the details of your medical history should interpret and give you advice. ...Read more