Doctor insights on:
Actoplus Met Medication
Investigational: NEO 102 is a monoclonal antibody, not what is usually meant by the word chemotherapy. It is the subject of ongoing clinical trials. Therefore it is not yet known whether the drug is useful, harmful, or indifferent. In the U.S. it would only be available for subjects in a clinical trial. I suspect, but am not certain, that that is true in the U.K. Too. ...Read more
What's the prognosis for nsclc, st 4, mets, .Chemo stopped. Kras and tissue samples & new clin trial drug being discussed now. 10 mts diagnosed?
Hard to predict: Metastatic lung cancer as a whole has a history of poor long term survival. Unfortunately, the 5 yr survival is only about 10%. But this is dependent on many things including age and type of cancer. Also some people's tumors respond differently to chemo. Your cancer specialist may be your best resource. ...Read moreSee 1 more doctor answer
Will avastin (bevacizumab) increase survival significantly for metastic colon cancer with liver mets ?
Is it a risky drug
Slight benefit: Bevacizumab (Avastin (bevacizumab)) is one of those drugs that is extremely expensive and often has limited benefit. Patients with metastatic colon cancer who received Avastin (bevacizumab) plus chemotherapy lived 1-2 months longer on average than those receiving chemo only. Because it has marginal benefit but costs ~$30,000 the U.K. Health Service won't pay for it. It can cause skin rash, bleeding or wound healing problems. ...Read more
3 factors: The tumor must produce matrixmetalloproteinase (MMP) to allow entry into the blood stream. The MMP must breakdown -cadherin to small e cadherin for progression of tumor growth and new cells invading circulation must express a surface antigen that determins site of implantation. Ovary spread to omentum where TGF beta present, Colon to liver because matrix contains liver ferritin. ...Read more
Metastasis: A cancer begins in an organ (say the breast). If it gets into the blood stream or the lymphatic stream the cells can travel to other parts of the body where, in the right environment, they may settle and grow. This development of tumor growth far away from the original site is called a metastasis. ...Read moreSee 1 more doctor answer
Metastases from what: Assuming you mean SQUAMOUS CELL CARCINOMA, your question makes no sense without details. Does "multi" mean 3? More? How many? All at once or over some years? Are they in areas exposed to sun or radiation? Are they in anal or genital area? Do you have a transplant? On meds? What is your understanding of "METASTASIS"? Evaluation and treatment should be done by a skin specialist. ...Read more
Finished cardio rehab. Started with ef of 20 now 50. Lost 23lbs. Mets exercise tolerance went from 9.8 to 16.9. Good sign for future?
Different results: Metastasis arises from primary, the former being clonal and the primary, polyclonal. What spreads to a site such as liver or lung can only grow within that parenchyma and never spread elsewhere. The primary has multiple clones each only capable of spreading to a local site and growing there. Thus primary should always be removed and met focal disease treated later for best survival. ...Read more
These are 2 options: Xeloda (capecitabine) - is an oral chemotherapy drug that can be used for certain metastatic cancers alone or in combination with other chemotherapy drugs as palliative treatment. Zometa - is used in a situation where cancer has spread to the bones. Its not chemotherapy but a bisphosphanate, a medication used to prevent further weakening of bones by cancer and prevent fractures. In some situations both are given. ...Read more
Fundamental!: All living things need a blood supply to deliver food, water, and get rid of waste. A circulating cancer cell needs to evade detection, get out of the blood vessel, and establish that blood supply: angiogenesis!. All these actors under molecular control, and likely normal during in utero development. Cut off the blood supply, choke the tumor. ...Read more
Cancer spread. : Metastasis is the spread of cancer from the place that it formed to other organs in the body. This usually is a bad sign prognostically, indicating more aggressive behavior. Some cancers can metastasize early, and others rarely do. The "stage" of cancer is determined by multiple factors, depending on the type of cancer. The presence of metastases often means a higher stage, worse prognosis. ...Read moreSee 1 more doctor answer
That depends. : You ask a good question. I think it depends where the tumor or mets are located. With a spinal tumor i would anticipate worsening pain with growth, but initially it could fluctuate. Mets could cause both fluctuating and worsening pain, again depending on location. I would suggest seeing a local practioner if you are having pain or discomfort that are related to either if those things. ...Read more
Depends: A stage IV cancer-although it is treatable, unfortunately it is an incurable disease in majority cases. Some cancer like testicular cancer, however, can still be cured even though the cancer already spread beyond the primary organ. Lymphoma's prognosis is better than solid ca. The prognosis really depends on the type , the biology of cancer and your respond to treatment, overall condition etc. ...Read more